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ECOG-ACRIN Cancer Research Group

@eaonc.bsky.social
233 followers 135 following 153 posts

Biomarker-driven medical research involving adults who have or are at risk of developing cancer

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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 29/09/2026
Consistent, evidence-based funding has helped deliver major advances in #cancer treatment. @acscan.bsky.social shares its perspective on a reported change to #NIH grantmaking and what it could mean for research: bit.ly/4xPN16S
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ACS CAN Warns Political Interference Could Threaten Cancer Research
The American Cancer Society Cancer Action Network (ACS CAN) today expressed deep concern following media reports of a new planned executive order placing greater political control over research grant ...
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Reposted by ECOG-ACRIN Cancer Research Group
Alliance for Clinical Trials in Oncology @alliance-org.bsky.social · 21/09/2026
Thank you for sharing our powerful five-minute video @eaonc.bsky.social! I really helps frame clinical trials from the participant's point of view.
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 29/09/2026
The #BreastCancer study EA1242/RxFINE-Low is testing whether hormone therapy plus ribociclib, without chemotherapy, is as effective as standard treatment that includes chemotherapy. Learn more: bit.ly/ea1242-study
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 29/09/2026
#ClinicalTrial EA5221/ACHIEVE, led by Dr. Megan Baumgart, aims to help older patients with #LungCancer live longer while also maintaining a good quality of life. Learn more: bit.ly/ea5221-achieve #NSCLC #LCSM
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 28/09/2026
#ClinicalTrial EA7211/STRASS 2, led in the US by Dr. Kenneth Cardona, is the second randomized study ever performed in retroperitoneal soft tissue #sarcoma & is enrolling patients in the US, Europe, Canada, Australia, New Zealand, & Japan! Learn more: bit.ly/EA7211
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 25/09/2026
#FindingsFriday: New research from 9 ECOG-ACRIN Cancer Research Group trials found most patients who smoked before their #cancer diagnosis kept smoking—during and after treatment. #SmokingCessation support needs to be built into cancer care, not left to chance. Learn more: bit.ly/4dvJZxj
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 24/09/2026
ICYMI, more than a decade after TAILORx changed #BreastCancer care, its biorepository is yielding new insights: researchers used #AI to review archived pathology slides from 4,000+ trial participants, developing a more accurate recurrence-risk model. More: bit.ly/4cY42EB
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A new AI-powered test offers more accurate prediction of breast cancer recurrence risk
Learn how ECOG-ACRIN is using an innovative artificial intelligence (AI) model to create more accurate recurrence risk predictions in patients with early-stage breast cancer.
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 24/09/2026
EA8231 is a phase 3 study comparing pembrolizumab & sacituzumab govitecan versus standard chemotherapy in patients with advanced urothelial cancer. The trial aims to improve treatment options & guide further research. ➡️ bit.ly/ea8231-study
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 22/09/2026
Decades of federal investment in #CancerResearch have saved millions of lives. American Association for Cancer Research (AACR)'s Cancer Progress Report asks Congress to sustain NIH/NCI funding & protect grants from interference—because progress against #cancer depends on it. bit.ly/4xC3bRk
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 22/09/2026
Do you have #BreastCancer that was recently removed by surgery? If so, you may be eligible for clinical trial EA1242/RxFINE-Low, a study exploring potential new treatment approaches. More info: bit.ly/ea1242-study
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 22/09/2026
Do you have advanced non-small cell #LungCancer and are age 70 or older? If so, you may be able to participate in this study of a new treatment approach. Learn more: bit.ly/ea5221-achieve
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 21/09/2026
Can patients with high-risk retroperitoneal #sarcoma benefit from neoadjuvant chemotherapy? The international EA7211/STRASS 2 #ClinicalTrial, led in the US by Dr. Kenneth Cardona aims to find out. More: bit.ly/EA7211 cc: European Organisation for Research and Treatment of Cancer
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 18/09/2026
#FindingsFriday: New results from CompassHER2 pCR help identify factors associated w/ pathologic complete response in HER2+ #BreastCancer. Research like this moves us closer to more personalized treatment strategies. More in JCO Journals: bit.ly/4hqJjM3 #ClinicalTrials
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 17/09/2026
#CancerResearch advances through collaboration. In our latest Institution Spotlight, Dr. Joseph Sparano shares how the Mount Sinai Tisch Cancer Center is contributing to NCI-funded clinical research, incl. the ongoing EA1241 trial, while helping cultivate future leaders. More: bit.ly/4xt4ty2
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Institution Spotlight: Mount Sinai Tisch Cancer Center
Showcasing the center's commitment to training oncology researchers and improving patient outcomes through impactful cancer clinical trials
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 17/09/2026
Clinical trial EA8231, led by Monika Joshi, MD and Petros Grivas, MD, PhD, is a phase 3 randomized study exploring a new treatment approach for pts with treatment-refractory, locally-advanced or metastatic urothelial cancer. More information here: bit.ly/ea8231-study
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 15/09/2026
Powerful video by our colleagues at @alliance-org.bsky.social! #Cancer #ClinicalTrial participation can save lives.
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 15/09/2026
Clinical trial EA1242/RxFINE-Low, led by Dr. Nancy Chan of Perlmutter Cancer Center at NYU Langone Health, is testing whether hormone therapy plus ribociclib is as effective as chemotherapy followed by hormone therapy plus ribociclib in patients with #BreastCancer. More: bit.ly/ea1242-study
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 15/09/2026
The EA5221/ACHIEVE clinical study is testing two different treatment approaches for older adults with advanced non-small cell #LungCancer. Learn more: bit.ly/ea5221-achieve #NSCLC #LCSM
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 15/09/2026
#CancerResearch progress is not guaranteed. As the American Society of Clinical Oncology's Save Research campaign highlights, continued federal investment is critical to supporting researchers, fueling innovation, & advancing #ClinicalTrials. More: bit.ly/3V9APjK #SaveResearchStopCancer
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‘Save Research’ Campaign Champions Federal Funding
ASCO members are leading the way to make sure Congress understands the critical importance of federal cancer research funding before the September 30 federal funding deadline.    
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 14/09/2026
In #ClinicalTrial EA7211/STRASS 2, investigators are testing neoadjuvant chemotherapy followed by surgery vs. surgery alone for patients with high-risk retroperitoneal #sarcoma. More info: bit.ly/EA7211
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 10/09/2026
Encouraging news: #cancer survival rates among adolescents & young adults (#AYAs) continue to improve. Study authors: "Much of this progress can be attributed to national efforts led by NCI-funded cooperative groups to focus on AYA oncology." bit.ly/3TfrypP #AYACancer
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Young Adult Cancer Survival Rates Accelerate
Researchers have analyzed annual survival data between AYA patients aged 15-39 years and patients in younger and older age groups between 1975 and 2017.
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 09/09/2026
#Cancer #ClinicalTrials depend on a strong & stable research infrastructure. Consistent federal funding helps support the #science that brings innovative treatments to patients & advances cancer care. @americancancersoc.bsky.social is urging Congress to pass a full-year budget: bit.ly/4yr6sn9
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ACS CAN Calls on Congress to Pass Full-Year Budget; Preserve Stability in Federal Research Funding
Today, the House passed a continuing resolution (CR) to fund the federal government through mid-December.
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 02/09/2026
Federal investment in #cancer #ClinicalTrials matters. A recent study found that federally funded trials are more likely to examine rare & pediatric cancers, prevention strategies, supportive care, & ways to reduce treatment burden. More via @theaacr.bsky.social's blog: bit.ly/4zS7fzm
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Unboxing Cancer News, August 2026: Fishy Cancer, Federal- vs. Industry-funded Trials, and More
The August 2026 edition of “Unboxing Cancer News” highlights a transmissible cancer, federal- vs. industry-funded clinical trials, and more.
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 22/07/2026
ICYMI: For pts w/ standard-risk #MultipleMyeloma, longer treatment wasn't better. ENDURANCE found no overall survival benefit w/ indefinite lenalidomide therapy, supporting more informed treatment decisions & potentially reducing treatment burden. More: bit.ly/4yybi2Z
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 20/07/2026
New in @nejm.org, results from E1A11/ENDURANCE show no survival benefit—but more toxicity—w/ indefinite lenalidomide maintenance vs. a fixed 2-year duration in newly diagnosed #MultipleMyeloma. View the full publication: bit.ly/3QZOU1I #Myeloma #HemOnc
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Press Release: ECOG-ACRIN ENDURANCE trial findings published in the <em>New England Journal of Medicine </em>provide the first randomized evidence on the optimal duration of lenalidomide maintenance f...
Read more about the findings for this cancer clinical study for patients with newly diagnosed multiple myeloma
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 10/07/2026
#FindingsFriday: Our latest research round-up is here! Explore findings presented at #ASCO26 and #SNMMI26, including updates from EA6174/STAMP in #MerkelCellCarcinoma, EA1183/FEATURE in metastatic #BreastCancer, and EAF151 in #glioblastoma. Read more: bit.ly/4wyd0jb
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Trial Results: ECOG-ACRIN Research at ASCO and SNMMI 2026
Read about the latest discoveries in brain tumors, breast cancer, kidney cancer, lung cancer, Merkel cell carcinoma, and precision oncology
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 26/06/2026
We extend our deepest condolences to Dr. Gillison's family and to the many in our community who mourn her loss.
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 24/06/2026
New policy analysis raises concerns about the future of #ClinicalResearch. A proposed OMB rule could put a significant share of ongoing #ClinicalTrials at risk—highlighting the importance of protecting the research ecosystem. More via The Cancer Letter: bit.ly/3SjXskg
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OMB proposed rule could end 50% of currently active clinical trials, Stand up for Science analysis finds - The Cancer Letter
An analysis by Stand up for Science found that the White House Office of Management and Budget’s recently proposed rule, “Regulation for Federal Financial Assistance,” if finalized, could result in te...
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 17/06/2026
A new pub. introduces plasmaCHORD, a machine learning model to improve #LiquidBiopsy interpretation by distinguishing tumor-derived mutations from clonal hematopoiesis. Supported in part by our Thoracic Malignancies Transl. Sci. Ctr. grant. More: bit.ly/43xvxQd
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plasmaCHORD: A Machine Learning Approach to Distinguish Clonal Hematopoiesis–Derived Variants in Liquid Biopsies from Patients with Solid Tumors
AbstractPurpose:. Targeted next-generation sequencing (NGS) of cell-free DNA (cfDNA) enables comprehensive molecular profiling and can guide the selection of genotype-targeted therapies. However, the ...
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 10/06/2026
@eaonc.bsky.social Image Analytics Working Group Chair Dr. Elizabeth McDonald discusses results from a retrospective study showing that GLP-1 treatment was associated w/ a significantly lower incidence of #BreastCancer. Next step? A clinical trial. Watch the video: bit.ly/4aDDAyD
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Elizabeth McDonald, MD, PhD, on GLP-1 Agonists and Breast Cancer Incidence
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 09/06/2026
Congratulations to Dr. Heather Wakelee, on being named a 2026 Giant of Cancer Care in Thoracic Malignancies 👏 A well-deserved recognition of her leadership in advancing #LungCancer research and improving patient outcomes. Learn more: bit.ly/43VW0XG
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Wakelee honored with 2026 Giants of Cancer Care award
Stanford Cancer Institute deputy director recognized for advancing lung cancer treatment and research.
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 03/06/2026
New #MerkelCellCarcinoma data at #ASCO26, presented by Janice Mehnert, MD: While relapse-free survival did not meet statistical significance, adjuvant pembro significantly reduced distant spread—an important clinical signal in this rare cancer. More: bit.ly/3PxCeOU #SkinCancer
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Researchers from Perlmutter Cancer Center Present Latest Findings at 2026 ASCO Annual Meeting
NYU Langone Health’s Perlmutter Cancer Center experts presented clinical findings and research at the 2026 American Society of Clinical Oncology Annual Meeting.
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 02/06/2026
New insights from #ASCO26 Day 4 continue to shape the #oncology landscape—including updates from @eaonc.bsky.social studies in #NSCLC (EA5142/ALCHEMIST), and #MerkelCellCarcinoma (EA6174/STAMP). Helpful podcast summary for a quick download: bit.ly/4uRmiX8
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Podcast: Day 4: Top Takeaways From ASCO26
Dr. Monty Pal shares highlights from Day 4 of the 2026 ASCO Annual Meeting, including a much-anticipated study in hepatocellular carcinoma, new data in non–small cell lung cancer, and a key update in ...
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 19/05/2026
Sustained #CancerResearch funding fuels progress. Progress saves lives. @ascocancer.bsky.social is urging Congress to protect cancer research funding in FY27. Read the full statement: bit.ly/4v1rnM9 #NIH #HealthPolicy
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ASCO Urges Congressional Appropriators to Support Cancer Research in FY27 Budget - ASCO
The Association for Clinical Oncology (ASCO) is asking congressional appropriators to allocate $51.3 billion to the National Institutes of Health (NIH) for Fiscal Year (FY) 2027.
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 05/05/2026
The #EAOnc Spring 2026 Group Meeting officially begins today! Looking forward to seeing you in Baltimore. Check in at the registration desk on the 4th floor before heading to your first session. 🩺🩻📈
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 01/05/2026
#FindingsFriday: Don’t miss the newest round-up of recently published findings from @eaonc.bsky.social #ClinicalTrials. See key #CancerResearch results and why they matter: bit.ly/4ed3xb6
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 30/04/2026
Early onset #ColorectalCancer is rising. Genetics explain only part of it. @npr.org explores how the #GutMicrobiome may be a missing piece—highlighting the necessity of initiatives like our Microbiome Working Group: bit.ly/4uaZCQH
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Scientists search the microbiome for clues to the rise in colorectal cancers
Unlike many cancers, colorectal cancer has become more lethal for people at younger ages. Doctors are sleuthing out why.
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 28/04/2026
Attending our Spring 2026 Group Meeting next week? Don't miss the Comis Symposium (5/5 @ noon), focused on 'Susceptibility and Inflammation,' or the General Session (5/6 @ 9 am), ft. cutting-edge cancer vaccine development strategies. Read more: bit.ly/4vVjU2f
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From the Co-Chairs, April 2026
A preview of the upcoming Spring Group Meeting, a recap of AACR 2026, and a call for respectful disagreement
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 24/04/2026
#FindingsFriday: A new study using data from the E2993 #ClinicalTrial uncovers how acute #leukemia cells stabilize oncogenic tyrosine kinase signaling through dynamic feedback control—offering fresh targets for therapy. Read more in @science.org: bit.ly/4cUmWfJ
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Dynamic feedback control of oncogenic tyrosine kinase signaling in acute leukemia
PKCδ and CD25 assemble a complex for negative feedback control of tyrosine kinase signaling in acute leukemia cells.
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 14/04/2026
What did the PROSPER trial teach us about neoadjuvant therapy in #RenalCellCarcinoma—and what questions still remain? Our GU #Cancer Committee Chair Dr. Naomi Haas shares lessons learned and practical considerations: bit.ly/4vsG8Zd #KidneyCancer #RCC
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Neoadjuvant Approaches for Renal Cell Carcinoma | Targeted Oncology - Immunotherapy, Biomarkers, and Cancer Pathways
Dr Naomi Haas discusses the feasibility of neoadjuvant therapy in RCC, highlighting the PROSPER trial's results and its role in treating unresectable disease.
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 10/04/2026
Attending #AACR26 next week and interested in #RealWorldEvidence and #ClinicalTrial design? Don't miss Session MW04: Clinical Trial Design Workshop chaired by @eaonc.bsky.social Group Co Chair Dr. Peter O'Dwyer 🗓 Apr 17 | 3–4:30 PM | Room 31 #RWE #CancerResearch
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 08/04/2026
Proposed #NIH funding cuts and grant changes in the FY 2027 budget request could significantly slow progress in #CancerResearch—and ultimately impact patients. Read more via @ascocancer.bsky.social: bit.ly/4e6TX9p
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Proposed NIH Cuts, Funding Changes Risk Slowing Cancer Research - ASCO
Today, the administration released its Fiscal Year 2027 budget request, which proposes a 12% cut to the National Institutes of Health (NIH) and modest increase for the National Cancer Institute (NCI)....
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 01/04/2026
📊 How can #RealWorldData strengthen cancer #ClinicalTrial design? At #AACR26, join Session MW04: Clinical Trial Design Workshop – #RealWorldEvidence in Clinical Trial Design, chaired by @eaonc.bsky.social Group Co Chair Dr. Peter O'Dwyer🗓 Apr 17 | 3–4:30 PM | Room 31 #RWE #CancerResearch
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 31/03/2026
Early treatment for high risk #SmolderingMyeloma is no longer hypothetical—it’s FDA approved. Now #ClinicalTrials like EAA173 (DETER SMM) are critical to determine who benefits most and how much treatment is enough. Learn more about #SMM: bit.ly/4bVbJdk #MultipleMyeloma
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Bloodlines Series: What Is Smoldering Myeloma?
Learn what is smoldering myeloma and about the first treatment approved by the FDA to prevent its progression to active multiple myeloma.
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 19/03/2026
New video: Dr. Monika Joshi & @pgrivasmdphd.bsky.social discuss the EA8231 #ClinicalTrial, which aims to evaluate and answer the critical question of #immunotherapy (anti-PD1/L1) rechallenge in #UrothelialCancer therapy. Watch here: bit.ly/47UxFnr #BladderCancer
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EA8231 Research Study for Patients With Advanced Urothelial Cancer
Study chair Dr. Monika Joshi and co-chair Dr. Petros Grivas discuss this trial that aims to improve outcomes for patients with anti-PD(L)1-resistant advanced urothelial cancer.
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 19/03/2026
At #SSO2026 in early March, Dr. Maheswari Senthil presented results from the phase 2 STOPGAP trial for patients with #GastricCancer. This study laid the groundwork for ECOG-ACRIN Cancer Research Group's STOPGAP II, currently enrolling patients! More: bit.ly/47Bhbk1
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SSO 2026 Annual Meeting
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 11/03/2026
Urothelial cancer is the most common type of #bladdercancer. The EA8192 study is evaluating durvalumab and chemotherapy for patients with high grade upper tract urothelial cancer prior to nephroureterectomy. bit.ly/ea8192-trial
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 10/03/2026
New data show #NIH research grant success rates plummeted in 2025—falling to around ~19–20% overall & hitting early-career scientists especially hard. The ripple effects could shape the biomedical workforce for years. More: bit.ly/46PsJjq #ResearchFunding #SciencePolicy
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NIH research grant funding rates plummeted in 2025
Agency acknowledges young investigators are losing out as result of multiyear funding policy imposed by White House
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 27/02/2026
#FindingsFriday: ICYMI, new data from @precogonc.bsky.social PrE0405, presented at #ASH25, showed that treatment with BR-VEN led to high response rates & promising CR rates for older patients w/ mantle cell #lymphoma. More: bit.ly/4aReE69 #MCL
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Primary Analysis and Results of Bendamustine, Rituximab, and Venetoclax (BR-VEN) for Initial Treatment of Mantle Cell Lymphoma in Subjects over 60 Years of Age (PrE0405)
BackgroundMantle cell lymphoma (MCL) is an incurable form of aggressive non-Hodgkin lymphoma. Treatment choice at diagnosis is based on tolerability o…
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ECOG-ACRIN Cancer Research Group @eaonc.bsky.social · 26/02/2026
Debate continues: should #immunotherapy move earlier in undifferentiated pleomorphic #sarcoma ( #UPS ) care? Insights from Dr. Seth Pollack and the ECOG-ACRIN EA7222 trial shed light on evolving treatment paradigms. Watch the video: bit.ly/3OVL3ky
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Redefining Frontline Therapy in Undifferentiated Pleomorphic Sarcoma | CancerNetwork
Seth M. Pollack, MD, discussed how the ECOG-ACRIN EA7222 trial could establish doxorubicin/pembrolizumab as the new frontline standard for undifferentiated pleomorphic sarcoma.
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