Nature Reviews Cardiology, Published online: 18 September 2025; doi:10.1038/s41569-025-01219-xLarge-scale clinical trials presented at the ESC Congress 2025 support the use of high-dose vaccination for influenza to reduce hospitalization for cardiorespiratory disease in older adults and to improve outcomes in patients who have been hospitalized for acute heart failure.

In this in-depth analysis of the Altshock-2 trial (Study on Early Intra-aortic Balloon Pump Placement in Acute Decompensated Heart Failure Complicated by Cardiogenic Shock), Harlan M Krumholz, MD, FAC...

AbstractBackground. BRCA1/2 genes play a critical role in genome stability and DNA repair. In animal models, loss of cardiomyocyte-specific BRCA1/2 is asso

Keyl et al. present an explainable artificial intelligence model-based real-world data analysis from over 15,000 patients across 38 cancer types, identified key prognostic marker interactions, and con...

Sivatharshini Ramalingam, MD, and Charlotte Manisty, MBBS, PhD, discuss JACC: CardioOncology Expert Panel Recommendations for cardiovascular risk evaluation prior to cancer treatment, cardiac nuances ...

Immune checkpoint inhibitors may heighten cardiovascular risks by altering immune interactions in atherosclerotic plaques, particularly in diabetic patients.