iiinova — where your digital self keeps evolving

DrLachie @drlachie.bsky.social · 16/10/2026

Haven't done an animation in a while. Lucky for me @amsikking.bsky.social came up with a "Dual-Grind" snouty light sheet objective - amsikking.github.io/idv-snouty_l.... I happily present a look into their manufacture.

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DrLachie @drlachie.bsky.social · 15/10/2026

Yeah, I'm not inclined to go silent. The sound is so satisfying! I think my first upgrade is going to be a second one for my work PC - although I'll see how my officemates feel about that.

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DrLachie @drlachie.bsky.social · 15/10/2026

Unexpected consequence however. My wife has had to start wearing headphones on days when we're sharing the home office....

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DrLachie @drlachie.bsky.social · 14/10/2026

Had a sleep study done recently and just got the results back. There's nothing wrong with me. I just snore, and I guess any fatigue I have is just the natural result of living in the modern world.

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DrLachie @drlachie.bsky.social · 13/10/2026

My preferred coffee roaster has a chatbot on its site so I decided to ask it about grind size of a blend I bought. It didn't know the answer but an hour or so later I got an email from a human answering me. I feel bad, I was only asking becuase I don't care about wasting a robot's time!

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DrLachie @drlachie.bsky.social · 10/10/2026

We've had a house full of teenagers for our eldest's birthday for the majority of Saturday afternoon. We've never earned a martini harder.

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DrLachie @drlachie.bsky.social · 10/10/2026

Oh I should have done this years ago. Even my kids love it - although that's probably the 15 different backlighting modes (the first thing I did was turn it off, the first thing they did was demand I show them how to turn it back on).

E-YOOSO z99 mechanical keyboard with RGB backlights. It's very pretty.

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DrLachie @drlachie.bsky.social · 10/10/2026

E-YOOSO 99keys is on its way. I have more than one computer so even if I've made a mistake here I can make amends on the next one 😀

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DrLachie @drlachie.bsky.social · 09/10/2026

Lol your name came up. Dipping my toe with a relatively cheap model that has two things a kind of need: wireless and numeric keypad. But I know it's a rabbit hole so will see where it leads.

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DrLachie @drlachie.bsky.social · 09/10/2026

Oh now that would also interest me... This is going to end up an expressive post

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DrLachie @drlachie.bsky.social · 09/10/2026

I mean if you can't trust a cowpuppy cat, who can you trust?

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DrLachie @drlachie.bsky.social · 09/10/2026

Well I can't afford to get into the watch collecting which also seems to overlap

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DrLachie @drlachie.bsky.social · 09/10/2026

I'm kind of afraid of that

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DrLachie @drlachie.bsky.social · 09/10/2026

Considering buying a mechanical keyboard. I feel like they're the computer peripheral equivalent of fountain pens so right up my alley....

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DrLachie @drlachie.bsky.social · 05/10/2026

I bought a new - coffee specific - thermos. I'm much happier now.

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DrLachie @drlachie.bsky.social · 02/10/2026

Made myself a pour-over coffee this morning to take to work. Put it in the thermos my son often uses for his school lunches. Now I'm a fan of interesting coffee but I don't think the "notes of butter chicken" was entierly the intention of the roaster.

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DrLachie @drlachie.bsky.social · 01/10/2026

Ok so this is ongoing huh? I can't help but think we should have seen some greyscale raw data by now....

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DrLachie @drlachie.bsky.social · 30/09/2026

Heading back to the real world today, and back at work tomorrow. I apologise in advance to anyone who needs my full attention, my brain will be here for a day or two more.

Blue skies, green trees, blue pool. In that order.

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DrLachie @drlachie.bsky.social · 28/09/2026

Gotta watch out for crocs up here.

A sign warning to beware it crocodiles at palm cove beach. Behind the sign is a pair of crocs (the shoes). It's a hilarious joke, regardless of what my wife and children may think.

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DrLachie @drlachie.bsky.social · 25/09/2026

Sure I could ask AI to indentify this bird, but my kids have decided it's called the "cheese face bird" and who am I to disagree?

Photo of the cheese face bird. It looks like it has cheese melted over its beak (kind of)

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DrLachie @drlachie.bsky.social · 23/09/2026

If this is still topical in a week I'll see what I can do

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DrLachie @drlachie.bsky.social · 23/09/2026

If I wasn't away from home I'd have a model of this by the afternoon, so many possibilities.

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DrLachie @drlachie.bsky.social · 23/09/2026

It's a little damp and cooler than previous years, but still - it's a great place to wake up.

My morning coffee on a balcony in tropical North Queensland

View from my window. Very green and tropical, if a little wet this morning

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DrLachie @drlachie.bsky.social · 21/09/2026

I would go to the conference just to see how they pronounce it. I hope it's exactly as written.

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Reposted by DrLachie

Emily M. Bender @emilymbender.bsky.social · 20/09/2026

The AI bros would like us to believe that much of what we spend our time on is busywork/drudgery/tedium and we would be so much better off if that could be delegated. >>

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DrLachie @drlachie.bsky.social · 20/09/2026

Week 1 of going (back) to the driving range: "Oh I vaguely remember this" Week 2: "Oh it's starting to come back" Week 3: "Hey, I'm getting pretty good" Week 4: "Which end of golf stick for holding and which end for hitting?"

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DrLachie @drlachie.bsky.social · 18/09/2026

Why is it always on the days where I have so much stuff to do that the network goes down? This will make next week significantly more stressful than I would like before I go on holiday.

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DrLachie @drlachie.bsky.social · 17/09/2026

Had a sleep study done. I think it's a serious fulfilling prophecy. "Wow, you sleep terribly*" *When you're connected to the wall by a hundred wires connected to your face.

Photo of terrible cable management going into a detector. The unshown other end of the cables are on my face.

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DrLachie @drlachie.bsky.social · 14/09/2026

Had a seminar from a scientific recruiter yesterday. Really interesting to see how the world outside academia functions and the ways in and out of it. I'm not sure I'm down with posting daily on linkedIn though.

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DrLachie @drlachie.bsky.social · 13/09/2026

I like that my local driving range has ball tracking, I particularly enjoy the "ego boost" button (or "convert" as they call it which translates to "yes you hit 170, but if you were using quality golf balls it would have flown over 200!" still all over the shop though)

Screenshot of my range practice. Or random dots thrown overlayed on a fairway. It's hard to tell which.

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DrLachie @drlachie.bsky.social · 11/09/2026

Also, for any US followers: the AFL Grand final (our Superbowl) is on at the same ground in a couple of weeks. Expect another 100k people and a game that's an order of magnitude more confusing.

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DrLachie @drlachie.bsky.social · 11/09/2026

I've decided to start posting here again. But I will try and keep it light in response to *gestures vaguely at everything* Was cool to have the NFL in Melbourne. I wish I could have gone (if the Seahawks ever make it down here I will sell a kidney to go)

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DrLachie @drlachie.bsky.social · 11/09/2026

Reading a paper that involves a 2048-dimensional latent space. How do you even start to think about these? It's actually quite simple, just think about an N dimensional space, and set N to 2048.

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DrLachie @drlachie.bsky.social · 10/09/2026

Thanks for indulging me. This is the first publication entirely driven by the Bioimage Analysis Core at @wehi-research.bsky.social and I can't thank everyone involved, but know that you're all appreciated and I wish all your lattice data be manageable! We can help with that!

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DrLachie @drlachie.bsky.social · 10/09/2026

Thanks also to all the authors for the contributions. And mostly to lead author @pradeepr.bsky.social – who has never stopped thinking of improvements and passion for OSS has ensured that napari-lattice has become a useful piece of software for the community, not just a pipeline that only we can use

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DrLachie @drlachie.bsky.social · 10/09/2026

Finally (nothing is ever final), I want to thank everyone involved. Of course @krogersiooi.bsky.social our fearless leader, @niallgeoghegan.bsky.social wizard of the lattice, @haesleinhuepf.bsky.social for his GPU libraries. Michael Milton for wrangling our spaghetti code into a modern structure.

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DrLachie @drlachie.bsky.social · 10/09/2026

But @DrLachie I hear you say – what if your cells move! Well I'm glad you asked (kind of), we've toyed with a workaround and are looking at integrating tracking data into our pipeline – so keep an eye on the github for new features as we develop them!

A moving cell is tracked across the field by an ROI drawn at each timepoint.

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DrLachie @drlachie.bsky.social · 10/09/2026

But why do one-by-one when you can do ALL AT ONCE! As a part of the development, we built in flexibility to parallelise over any parameter. ROI was the obvious one, but you could also do by time point, channel, even Z-range if you really wanted. All HPC enabled!

ANALYSE ALL THE THINGS! (Apologies to Hyperbole and a Half)

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DrLachie @drlachie.bsky.social · 10/09/2026

So, we (mostly @pradeepr.bsky.social ), started developing a pipeline that would take ROIs extract and only process those one-by-one - rather than the whole image Around here we also got a small development grant from @chanzuckerberg.bsky.social to make it into a @napari.org plugin.

napari-lattice - A napari plugin for processing Lattice Light Sheet or other Oblique Plane Microscopy data

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DrLachie @drlachie.bsky.social · 10/09/2026

We mostly use the LLSz for cellular imaging and we made the observation that in a field of view full of cells, more often than not, the cells are actually all independent measurements. If they don't interact, (or move much), why are we processing the whole image? Most of the image is empty!

Maximum intensity projection of a relatively sparse field of cells.

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DrLachie @drlachie.bsky.social · 10/09/2026

When we purchased our Zeiss Lattice Light Sheet all the problems we thought we knew from previously building our own were amplified by how much data it could acquire quickly. LLS data needs to be deskewed before viewing or analysis, if you want to add deconvolution – GPUs start catching fire

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DrLachie @drlachie.bsky.social · 10/09/2026

Proud to present the publication of napari-lattice – our solution to the immense computational requirements of Lattice Light Sheet and Oblique Plane Microscopy. onlinelibrary.wiley.com/doi/10.1111/... Before I get into the thread, the important part is on github: github.com/BioimageAnal... (1/n)

onlinelibrary.wiley.com

napari‐lattice: A user‐friendly image processing tool for lattice light‐sheet microscopy data

Lattice light-sheet microscopy (LLSM) enables researchers to capture high-speed 3D videos of living cells with high definition and minimal damage. However, this technology generates terabytes of data....

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DrLachie @drlachie.bsky.social · 30/08/2026

Bought a new grinder and it changed my morning workflow. I wish there was a way to make coffee after having coffee.

Coffee grounds that have missed the container designed to catch them, because the container was not in place.

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Reposted by DrLachie

Australian BioImage Analysts' Society @ausbias.org · 03/08/2026

In a talk out of left field for us, this Month's AusBIAS meeting was @pradeepr.bsky.social taking us back to Ancient Rome to investigate whether image anlaysis can help read scrolls that haven't been read for nearly two thousand years. www.youtube.com/watch?v=mPtS...

youtube.com

AusBIAS July 2026 - Pradeep Rajasekhar

YouTube video by AusBIAS

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DrLachie @drlachie.bsky.social · 17/07/2026

I can't believe I haven't even made a move and @niallgeoghegan.bsky.social is already a piece and a half up! I think he's in cahoots with my pets. The cat knocks them down and the dog finishes them off.

A chess set with wooden pieces. The rook is missing and the knight has been obviously chewed but a troublesome poodle.

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DrLachie @drlachie.bsky.social · 15/07/2026

And I think today, Wordle has jumped the shark.

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DrLachie @drlachie.bsky.social · 15/07/2026

Can't believe someone has beaten me to register drlachie.com

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