We are pleased to announce the publication of a new Open Educational Resource (OER) on the Sheffield Pressbooks Network.

The intracellular subtilisin proteases (ISPs) are the only known members of the important and ubiquitous subtilisin family that function exclusively within the cell, constituting a major component of the degradome in many Gram-positive bacteria. The first ISP structure reported herein at a spacing of 1.56 Å reveals features unique among subtilisins that has enabled potential functional and physiological roles to be assigned to sequence elements exclusive to the ISPs. Unlike all other subtilisins, ISP from B.

The molecular mechanism has been uncovered by which zinc-dependent proteins, known as macrodomains, reverse ADP-ribosylation—a key regulatory process in cells linked to cancer and viral infections.

PhD Project - Unveiling the Secrets of Intrinsically Disordered Proteins in Gene Regulation at University of Sheffield, listed on FindAPhD.com

Cancer is one of the most formidable health challenges of our time, affecting nearly half of us during our lives. While treatments have significantly improved in recent decades, the biggest challenge ...

As part of a drug discovery programme to discover new treatments for human African trypanosomiasis, recombinant trypanothione reductase from Trypanoso…

Trypanothione replaces glutathione in defence against cellular damage caused by oxidants, xenobiotics and methylglyoxal in the trypanosomatid parasites, which cause trypanosomiasis and leishmaniasis....

ADP-ribosylation of proteins and nucleic acids regulates various cellular functions in all kingdoms of life, and its manipulation holds potential for human therapeutics. 60 years after the discovery of ADP-ribosylation, this review provides state-of-the-art insights on structural biology, biochemistry, cell biology, and clinical aspects.

Bacic et al. demonstrate that PARP1/HPF1 preferentially modify histone tails closest to the DNA break, directing ALC1-catalyzed nucleosome sliding. These findings suggest a mechanism for rendering DNA...

Crystallization and preliminary X-ray analysis of Leishmania major glyoxalase I