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Annabelle Singer

@drannabellesinger.bsky.social
292 followers 409 following 51 posts

Neuroscientist & Neuroengineer at Georgia Tech and Emory. Learning, memory, and memory impairment in disease, oh my.

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Reposted by Annabelle Singer
Nobel Prize @nobelprize.org · 05/10/2026
BREAKING NEWS The 2026 Nobel Prize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”
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Annabelle Singer @drannabellesinger.bsky.social · 14/05/2026
This work was led by Matthew Attokaren and Lu Zhang @gmbcrazy.bsky.social
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Annabelle Singer @drannabellesinger.bsky.social · 14/05/2026
it also reduced delta activity and increased low-alpha functional connectivity. This expands gamma sensory stimulation beyond neurodegenerative disease and suggests it may be a broader tool for modulating cognition. Full paper is here: doi.org/10.1162/IMAG...
doi.org
40 Hz audiovisual stimulation improves sustained attention and related brain oscillations
Abstract. Gamma oscillations (30–100 Hz) have long been theorized to play a key role in sensory processing and attention by coordinating neural firing across distributed neurons. Gamma oscillations ca...
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Annabelle Singer @drannabellesinger.bsky.social · 14/05/2026
Our new paper shows that 40 Hz audiovisual stimulation (“gamma flicker”) improved sustained attention: people responded faster and more accurately during a vigilance task. Unexpectedly, stimulation didn’t just increase 40 Hz brain activity...
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Annabelle Singer @drannabellesinger.bsky.social · 14/05/2026
Wait… flickering lights actually make you pay attention better? Gamma sensory flicker has been studied for Alzheimer’s disease, but here we asked a different question: Can it help healthy brains focus right now? Apparently… yes. (We were surprised too.) Paper here: doi.org/10.1162/IMAG...
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Annabelle Singer @drannabellesinger.bsky.social · 24/04/2026
I am honored to have been inducted into the @aimbe-official.bsky.social College of Fellows. I am grateful to my lab and collaborators for their hard work discovering how neural activity shapes memory and brain health and translating those insights into new therapies. bme.gatech.edu/news/bme-fac...
bme.gatech.edu
BME Faculty Elected to the AIMBE College of Fellows
Chethan Pandarinath and Annabelle Singer were elected by peers and members into the AIMBE College of Fellows as part of the Class of 2026.
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Annabelle Singer @drannabellesinger.bsky.social · 18/03/2026
White House lifts hold on NIH research spending www.science.org/content/arti...
science.org
Science | AAAS
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Reposted by Annabelle Singer
Institute for Neuroscience, Neurotechnology, and Society @gt-neuro.bsky.social · 27/01/2026
Can flickering light and sound help in the fight against Alzheimer’s disease? #ICYMI, BME's Holy Shift! podcast with @drannabellesinger.bsky.social explores how her early interest in theater lighting led to groundbreaking research on brain rhythms and memory. 🎧: holyshiftresearch.transistor.fm/5
holyshiftresearch.transistor.fm
Holy Shift! Biomedical Breakthroughs Shaping Tomorrow | Lights, Camera, Memory! | Annabelle Singer
Can flickering light and sound help fight Alzheimer’s disease?  On this episode of Holy Shift!, host Angela Gill Nelms chats with Dr. Annabelle Singer from Georgia Tech and Emory University, whose ...
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Reposted by Annabelle Singer
Jeff Markowitz @vulcnethologist.bsky.social · 04/03/2026
Second preprint from the lab. Collab with @dkoveal.bsky.social, with many more to come! Effort led by @xshirleyz.bsky.social with help from Brittany Addison, @ezeyulu00.bsky.social, Claire Deng (on the grad school market, better act fast, Claire’s amazing!), @ajemanuel.bsky.social, and many others!
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Annabelle Singer @drannabellesinger.bsky.social · 06/01/2026
"...Add soccer practice and music lessons and doctors’ appointments, and so begins a tormented dance of the privileged, to-ing and fro-ing through rush hour as any zest for life disintegrates." This one sentence eloquently tells the story of a daily parenting struggle www.nytimes.com/2026/01/05/u...
nytimes.com
The Robot Cars Have Come for the Kids
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Annabelle Singer @drannabellesinger.bsky.social · 20/11/2025
Check out this podcast highlighting our research and BME research more broadly. Thanks @danzigerzachary.bsky.social and Erin Buckley for making this happen
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Reposted by Annabelle Singer
Lena Ting @lenating.bsky.social · 15/11/2025
Garrett Stanley and I are leading the recruitment of a senior faculty position in BME at Georgia Tech and Emory, focused on Neural Engineering. Come talk to us, we're looking for a leader in research and training, in areas with neurotranslation potential. More details here: lnkd.in/eusCqCSR
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Society for Neuroscience @sfn.org · 03/09/2025
Submissions for late-breaking abstracts are now open!   Share your most recent and exciting research with a global audience at #SfN25.  Submit your late-breaking abstract by Wednesday, September 10.  🔗 vist.ly/45gzc #neurosky #neuroskyence #academicchatter
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Annabelle Singer @drannabellesinger.bsky.social · 24/07/2025
and was made possible by collaborations with the labs of Levi Wood and @sloanlab.bsky.social Preprint is here: www.biorxiv.org/content/10.1...
biorxiv.org
Sensory neurostimulation promotes stress resilience with frequency-specificity
Chronic stress is a major risk factor for neuropsychiatric disorders, acting via increased neuroinflammation and disrupted synaptic plasticity. While non-invasive visual or audiovisual neurostimulatio...
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Annabelle Singer @drannabellesinger.bsky.social · 24/07/2025
This work points towards a promising, non-invasive path for building resilience to stress and stress-related neuropsychiatric disorders. This study was made possible via generous support from the @brightfocus.bsky.social, @alzassociation.bsky.social‬, and the NIH
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Annabelle Singer @drannabellesinger.bsky.social · 24/07/2025
Tina’s idea turned out to be true, and we were surprised to find that 10Hz sensory stimulation was the most beneficial in males, while 40Hz was the most beneficial in females. This is a fundamentally new approach to mitigate the damaging effects of chronic stress.
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Annabelle Singer @drannabellesinger.bsky.social · 24/07/2025
Tina’s insight was based putting together separate fields showing, on the one hand that chronic stress causes damage via maladaptive neuroimmune responses and on the other hand that sensory stimulation alters neuroimmune function in unstressed conditions.
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Annabelle Singer @drannabellesinger.bsky.social · 24/07/2025
Can we experience stress without the damaging effects? Here, we find that non-invasive sensory stimulation at the right frequency induces stress resilience. Tina started this project with a creative idea: can we use sensory stimulation to prevent the damaging effects of chronic stress?
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Annabelle Singer @drannabellesinger.bsky.social · 24/07/2025
Check out new findings from @TinaFranklin: "Sensory neurostimulation promotes stress resilience with frequency-specificity" on bioRxiv: www.biorxiv.org/content/10.1... Chronic stress is a major risk factor for neuropsychiatric and neurodegenerative diseases, but for many of us it's unavoidable.
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Reposted by Annabelle Singer
Society for Neuroscience @sfn.org · 14/07/2025
#SfN25 provides an unparalleled scientific program highlighting emerging science from across the field. Get a first look at speakers, events, lectures, and more in the Neuroscience 2025 Preliminary Program. 🔗 vist.ly/3xvcw Drop a comment below to let us know your big three! #neurosky
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Annabelle Singer @drannabellesinger.bsky.social · 10/07/2025
and by funding from the CART foundation, the NIH, the NSF, the BrightFocus foundation, and the Alzheimer’s Association. The paper is here: doi.org/10.1063/5.02...
doi.org
Frequency and duration of sensory flicker control transcriptional profiles in 5xFAD mice
Current clinical trials are investigating gamma frequency sensory stimulation as a potential therapeutic strategy for Alzheimer's disease (AD); yet, we lack a c
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Annabelle Singer @drannabellesinger.bsky.social · 10/07/2025
These insights enable stimulation “tuning” to target specific functions. This work also highlights how flicker stimulation has multiple biological effects and we think such a multipotent therapeutic approach is required for neurodegenerative diseases. This study was made possible by Levi Wood’s lab
doi.org
Frequency and duration of sensory flicker control transcriptional profiles in 5xFAD mice
Current clinical trials are investigating gamma frequency sensory stimulation as a potential therapeutic strategy for Alzheimer's disease (AD); yet, we lack a c
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Annabelle Singer @drannabellesinger.bsky.social · 10/07/2025
Check out new work by Sara Bitarafan showing that the frequency and duration of audiovisual flicker stimulation are key variables that dictate how flicker affects immune, neuronal, and metabolic genes in the context of Alzheimer’s disease pathology: doi.org/10.1063/5.02....
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Annabelle Singer @drannabellesinger.bsky.social · 09/07/2025
‪‪@stephmprince.bsky.social‬'s‬ recent paper was included in the Editors’ page “From brain to behaviour”. Check it out here: www.nature.com/collections/... Editors’ Highlights pages showcase exciting recent papers in an area.
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Annabelle Singer @drannabellesinger.bsky.social · 26/06/2025
The paper is here: www.nature.com/articles/s41...
nature.com
New information triggers prospective codes to adapt for flexible navigation - Nature Communications
Neural mechanisms underlying flexible navigation are not fully understood. Here authors reveal how neural circuits dynamically adapt navigational plans in response to new information. Hippocampal circ...
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Annabelle Singer @drannabellesinger.bsky.social · 26/06/2025
Joshua Stewart explains our recent paper by @stephmprince.bsky.social on how our brains adapt in a dynamic environment to still reach our destination: coe.gatech.edu/news/2025/06... This work was supported by the NIH, NSF, McCamish Foundation, and Packard Foundation
coe.gatech.edu
How New Information Triggers the Brain to Navigate Changing Environments
Biomedical engineers show how two brain regions quickly adapt to shift focus from one planned destination to another.
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Annabelle Singer @drannabellesinger.bsky.social · 13/06/2025
I can be your sponsor
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Annabelle Singer @drannabellesinger.bsky.social · 06/06/2025
No but I'd love to know how it goes. 😬
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Annabelle Singer @drannabellesinger.bsky.social · 31/05/2025
SFN abstracts are due Wednesday, June 4, at 5 p.m. Eastern Daylight Time.
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Annabelle Singer @drannabellesinger.bsky.social · 28/05/2025
Steph pioneered this new take on prospective codes including this complex behavior. The paper would not have been possible without the help of Danielle Cushing. Link for the smart PDF: rdcu.be/enokS
rdcu.be
New information triggers prospective codes to adapt for flexible navigation
Nature Communications - Neural mechanisms underlying flexible navigation are not fully understood. Here authors reveal how neural circuits dynamically adapt navigational plans in response to new...
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Annabelle Singer @drannabellesinger.bsky.social · 28/05/2025
These findings clarify long-standing debates about whether these codes steer behavior towards upcoming choices or represent all possible paths.
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Annabelle Singer @drannabellesinger.bsky.social · 28/05/2025
Finally, we find that hippocampal representations of the new future goal increased more when animals needed to adapt their behavior more in response to the new information. This shows that the degree of adaptation needed is a key overlooked variable regulating prospective codes.
media.tenor.com
a man in a blue jacket says " adapt or die " in a movie scene
ALT: a man in a blue jacket says " adapt or die " in a movie scene
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Annabelle Singer @drannabellesinger.bsky.social · 28/05/2025
This shows for the first time that prospective codes are actively modulated by new task-relevant information.
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Annabelle Singer @drannabellesinger.bsky.social · 28/05/2025
In hippocampus, we found that new, pivotal information causes non-local representations of both possible goal locations to rapidly increase, simulating both possible outcomes. In prefrontal cortex we found that pivotal information causes choice codes to rapidly switch to represent the new choice.
media.tenor.com
a young boy is eating a piece of ice cream .
ALT: a young boy is eating a piece of ice cream .
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Annabelle Singer @drannabellesinger.bsky.social · 28/05/2025
To do this, Steph developed a new behavioral paradigm in which we leverage a dynamic, virtual-reality environment to precisely control the introduction of new information while animal’s choices are evolving in a memory-based decision-making task.
media.tenor.com
a cartoon drawing of minnie mouse wearing a red dress with white polka dots
ALT: a cartoon drawing of minnie mouse wearing a red dress with white polka dots
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Annabelle Singer @drannabellesinger.bsky.social · 28/05/2025
We live in a dynamic world, but we often study navigation as if the world is static. So how do we flexibly adapt in the face of new, pivotal information? @stephmprince.bsky.social addresses just that question in her latest paper: www.nature.com/articles/s41....
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Reposted by Annabelle Singer
Steph Prince @stephmprince.bsky.social · 27/05/2025
Excited to share the last project from my PhD is officially published: www.nature.com/articles/s41...!
nature.com
New information triggers prospective codes to adapt for flexible navigation - Nature Communications
Neural mechanisms underlying flexible navigation are not fully understood. Here authors reveal how neural circuits dynamically adapt navigational plans in response to new information. Hippocampal circ...
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Reposted by Annabelle Singer
Society for Neuroscience @sfn.org · 21/05/2025
📣 #SfN25 abstract submission is now open! Share your research with the global neuroscience community. Start now to avoid the last-minute rush! 🔗 bit.ly/3G5vEde #NeuroSky #AcademicChatter
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Annabelle Singer @drannabellesinger.bsky.social · 15/05/2025
A major milestone for biomedical science and people with uncommon genetic disease: "KJ’s treatment — which built on decades of federally funded research — offers a new path for companies to develop personalized treatments" www.nytimes.com/2025/05/15/h...
nytimes.com
Baby Is Healed With World’s First Personalized Gene-Editing Treatment
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Annabelle Singer @drannabellesinger.bsky.social · 14/05/2025
Thanks you NIA for making this work possible
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Annabelle Singer @drannabellesinger.bsky.social · 14/05/2025
@gatechengineers.bsky.social @gt-neuro.bsky.social uro.bsky.social @gtresearchnews.bsky.social
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Annabelle Singer @drannabellesinger.bsky.social · 14/05/2025
Our research, funded by the NIH, was just featured on FOX 5! Thanks to interviewer Kevyn Stewart for sharing how Nuri Jeong's grandmother inspired her research, recently published in @nature.com. Get a glimpse into the lab here: www.fox5atlanta.com/news/georgia...
fox5atlanta.com
Georgia Tech researchers discover key neuron behavior with potential to restore memory in Alzheimer's patients
Researchers at Georgia Tech have uncovered findings with implications for understanding memory and learning, which could lead to restoring memory in Alzheimer's patients.
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Reposted by Annabelle Singer
Jeff Markowitz @vulcnethologist.bsky.social · 08/05/2025
Wrote a review with some thoughts about dopamine's role in movement. Hope people find it useful and/or stimulating! Thanks again to @bensaunders.bsky.social for the invitation and editing this issue. kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
kwnsfk27.r.eu-west-1.awstrack.me
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Annabelle Singer @drannabellesinger.bsky.social · 23/04/2025
This study reveals that chronic 40 Hz flicker enhances hippocampal activity that is essential for memory. This work also demonstrates a new way to evaluate brain stimulation for Alzheimer’s disease, by assessing its effects on memory processes. Full paper is here: www.pnas.org/doi/10.1073/...
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Annabelle Singer @drannabellesinger.bsky.social · 23/04/2025
We found 40 Hz flicker increases CA3-CA1 coordination during navigation. CA3-CA1 interactions play a central role in representing future experiences.
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Annabelle Singer @drannabellesinger.bsky.social · 23/04/2025
Using recordings of 1000s of neurons during virtual reality navigation behavior and Bayesian decoding, Abby discovered that 40 Hz flicker enhances representations of future positions, or prospective coding. These representations of future position coincide with efficient and engaged navigation.
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Annabelle Singer @drannabellesinger.bsky.social · 23/04/2025
Despite recent work on how 40 Hz sensory stimulation, or “flicker” affects disease models and human patients, it’s unknown how flicker impacts neural correlates of memory.
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Annabelle Singer @drannabellesinger.bsky.social · 23/04/2025
Check out our new paper out today in PNAS: “40 Hz sensory stimulation enhances CA3-CA1 coordination and prospective coding during navigation in a mouse model of Alzheimer’s disease”. www.pnas.org/doi/10.1073/... Led by Abigail Paulson with Lu Zhang and Ashley Prichard @amprichard.bsky.social
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Reposted by Annabelle Singer
Institute for Neuroscience, Neurotechnology, and Society @gt-neuro.bsky.social · 15/04/2025
Inspired by Georgia Tech researchers' personal experiences with Alzheimer's, a recent study published in @nature.com shows how inhibition isn't just about stopping activity but precisely timing it to enhance learning. neuro.gatech.edu/when-less-mo...
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Annabelle Singer @drannabellesinger.bsky.social · 11/04/2025
The scientific paper is here: www.nature.com/articles/s41...
nature.com
Goal-specific hippocampal inhibition gates learning - Nature
Parvalbumin-positive interneurons in the hippocampal CA3 substantially reduce firing on approach to and at goal locations while food-deprived mice learn to find food.
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