Reposted by Stan FlorescoZach Pennington @zachtpennington.bsky.social · 01/10/2026I'm SO excited to have this out in the world!!!! Check out our latest work on the contribution of the anterior hypothalamic nucleus to stress sensitivity and valence processing. 46817
Stan Floresco @dr-stan.bsky.social · 14/09/2026*sigh*- zero for two on your righteousness metric... 020
Stan Floresco @dr-stan.bsky.social · 13/09/2026static.klipy.comRyan Reynolds Says GeniusALT: Ryan Reynolds Says Genius 111
Stan Floresco @dr-stan.bsky.social · 10/09/2026I am truly humbled, and elated for this recognition, and grateful to my mentors, colleagues, trainees and family who've supported me on this journey 2422
Reposted by Stan FlorescoBita Moghaddam @bita137.bsky.social · 11/08/2026Love seeing entirely novel findings about dopamine Move over G proteins! Dopamine can regulate glutamate/NMDA directly and without second messenger systems: D2R physically couples GluN2B to suppress NMDA current directly 🤯 (congrats to team from Javitch & Ford labs) www.science.org/doi/10.1126/...science.orgDopamine D2 receptors bypass canonical signaling to directly tune NMDA receptor function and aversive learningDopamine acts at D2-NMDA receptor heteromers to control glutamatergic transmission and aversive learning. 15322
Stan Floresco @dr-stan.bsky.social · 23/07/2026Ahh yes. Triple G. Triple H's less successful older brother...static.klipy.comTriple H's Iconic EntranceALT: Triple H's Iconic Entrance 120
Stan Floresco @dr-stan.bsky.social · 20/07/2026static.klipy.comTheodoros Points and Makes a FaceALT: Theodoros Points and Makes a Face 011
Reposted by Stan FlorescoKiran Soma @kiransoma.bsky.social · 12/07/2026New preprint in which we developed a task to measure motivation to exercise in rats! This will hopefully open many doors. 🏃🐀 Big thanks to Prof. Desiree Seib, who led this effort, and @dr-stan.bsky.social !! www.biorxiv.org/content/10.6...biorxiv.orgA Novel Operant Conditioning Task to Assess Motivation to Exercise in RatsVoluntary physical activity is a highly motivated behavior with important implications for physical and mental health, yet the neural and endocrine mechanisms underlying motivation to exercise remain ... 2228
Reposted by Stan FlorescoNeuropsychopharmacology @npp-journal.bsky.social · 22/06/2026Glewwe et al. demonstrate that female mice outperform males in a touchscreen set-shifting task, suggesting that stable choice commitment in females paradoxically enhances cognitive flexibilitynature.comSex-biased computations underlying differential set shift performance in miceNeuropsychopharmacology - Sex-biased computations underlying differential set shift performance in mice 0128
Stan Floresco @dr-stan.bsky.social · 05/05/2026Favorite Instructor comment for the year: "Great professor! Very passionate (especially about catecholamines) and delivers information clearly. Also looks like Tony Stark and has the voice of a mix of Jack Black and Lin Manuel Miranda."🤷♂️static.klipy.comHamilton: It Must Be NiceALT: Hamilton: It Must Be Nice 090
Reposted by Stan FlorescoKiran Soma @kiransoma.bsky.social · 05/05/2026Congrats Des and Michelle @minseonjung.bsky.social !! 🤩 And thank you @joendocrinology.bsky.social I love this journal, which is owned by a scientific society and truly gives back to the scientific community. @socendocrinology.bsky.social 292
Reposted by Stan FlorescoPatrick Piantadosi @ppiantad.bsky.social · 09/10/2025for anyone interested in the amygdala and risky decision-making, check out our new preprint: biorxiv.org/content/10.1... amygdala neurons track reward-seeking actions, and punishment risk dramatically alters this function. lots of other (BLA-accumbens!) data included.biorxiv.orgRisk reshapes amygdala representation of choiceModifying behavior in response to changing environmental conditions is a crucial adaptive function. This capacity is exemplified when animals curtail pursuit of a valued outcome that risks being punis... 02310
Reposted by Stan FlorescoDr. Natasha Rajah, Ph.D. @mnrajah.bsky.social · 10/04/2026Dear reviewer, We all hate those pesky reminder emails to submit overdue reviews that are automatically sent by the journal’s system software. BUT if you’re several weeks late, maybe respond or decline reviewing so authors & EiCs aren’t stuck in limbo? #bekind #AcademicChatter 23510
Stan Floresco @dr-stan.bsky.social · 08/04/2026I grew up with phasic dopamine = reward prediction errors, phasic dips- negative prediction errors etc. Looks like that's not always the case- PFC DA signals seem to be doing something way different than in the striatum. So proud to be associated with this work. 091
Stan Floresco @dr-stan.bsky.social · 27/03/2026link.springer.com/article/10.1...link.springer.comCan the incentive-sensitization theory of addiction incorporate addiction to opioid drugs? - PsychopharmacologyThe Incentive Sensitization Theory (IST) of addiction posits that repeated intermittent exposure to potentially addictive drugs can sensitize brain mesolimbic dopamine systems. Those systems normally ... 020
Stan Floresco @dr-stan.bsky.social · 22/03/2026An excellent overview of contemporary issues with dopamine - WTF? (What's the function). Time to burn all the theories down, or maybe a set of adversarial collaborations? 041
Reposted by Stan FlorescoMonica H Green @monicamedhist.bsky.social · 16/03/2026Absolutely essential reading for anyone considering those "unicorn" hiring positions in Canada. Observations from researchers who are already there: www.nature.com/articles/d41... 🧪nature.comThe problem with Canada’s plan to buy scientific prestigeThe government’s plans to poach 100 US researchers might make good economic sense. But what about the existing community? 22928
Stan Floresco @dr-stan.bsky.social · 26/02/2026These data came out at a perfect time for a grant I'm retooling!media.tenor.coma picture of a man with the words excellent timing below himALT: a picture of a man with the words excellent timing below him 110
Stan Floresco @dr-stan.bsky.social · 26/02/2026This is a fantastic study! Thanks so much Kate, congratulations to you and your team! 110
Reposted by Stan FlorescoPhil Jean-Richard-dit-Bressel @philjrdb.bsky.social · 17/02/2026New paper from lab on how VTA dopamine neurons + GABA inhibition contribute to punishment learning. www.nature.com/articles/s41...nature.comDisinhibition of ventral tegmental area during initial punishment learning causes enduring punishment insensitivity - NeuropsychopharmacologyNeuropsychopharmacology - Disinhibition of ventral tegmental area during initial punishment learning causes enduring punishment insensitivity 2158
Stan Floresco @dr-stan.bsky.social · 12/02/2026media.tenor.coma group of people are sitting in a room and a woman is raising her fist in the air and says no more meetings .ALT: a group of people are sitting in a room and a woman is raising her fist in the air and says no more meetings . 020
Stan Floresco @dr-stan.bsky.social · 07/02/2026media.tenor.coma man in a plaid shirt and tie is sitting at a desk in front of a computer and talking .ALT: a man in a plaid shirt and tie is sitting at a desk in front of a computer and talking . 030
Reposted by Stan FlorescoBCCHR ResDev (DM) @resdevbcch.bsky.social · 29/01/2026Happy #CIHR notice of decision day to those who celebrate. Congratulations to 10-15% of you 🥳, and so very sorry to the other 85+% ☹️.media.tenor.coma cartoon of a cookie wearing sunglasses with the words " you 're one tough cookie stay strong " below itALT: a cartoon of a cookie wearing sunglasses with the words " you 're one tough cookie stay strong " below it 1223
Reposted by Stan FlorescoMathieu Ferron @mathieuferron.bsky.social · 29/01/202613.5% is the last success rate at CIRH. The government is slowly tanking the Canadian research system. 4136
Stan Floresco @dr-stan.bsky.social · 28/01/2026media.tenor.coma man in a green jacket is laughing with another manALT: a man in a green jacket is laughing with another man 010
Stan Floresco @dr-stan.bsky.social · 21/01/2026media.tenor.coma man in a batman costume with the words let 's get nuts behind himALT: a man in a batman costume with the words let 's get nuts behind him 010
Stan Floresco @dr-stan.bsky.social · 10/01/2026media.tenor.coma man is dancing in an arcade with the words hey now you 're an all star get your game on go playALT: a man is dancing in an arcade with the words hey now you 're an all star get your game on go play 010
Stan Floresco @dr-stan.bsky.social · 24/12/2025I'm so sorry l! Keep strong and hope they bounce back quick 110
Stan Floresco @dr-stan.bsky.social · 05/12/2025Congratulations to both you and @britt-chamberlain.bsky.social ! Can't wait to see the findings in print! 010
Stan Floresco @dr-stan.bsky.social · 01/12/2025www.jneurosci.org/content/45/4...jneurosci.orgComplementary yet Dissociable Influences of Medial and Lateral Orbitofrontal Cortex over Cue-Guided Decisions Involving Reward Magnitude and UncertaintyConverging evidence suggests that orbitofrontal cortex (OFC) subregions subserve distinct roles in decision-making across a variety of tasks. Cost/benefit decisions can require an organism to choose b... 020
Stan Floresco @dr-stan.bsky.social · 01/12/2025Thanks as always for your attention {cross posted on...the other place}media.tenor.coma man in a suit and tie stands in front of a crowd of peopleALT: a man in a suit and tie stands in front of a crowd of people 000
Stan Floresco @dr-stan.bsky.social · 01/12/2025Collectively, these results bolster a growing literature that mOFC and lOFC play distinct yet complimentary roles in the evaluation of outcomes and cues that inform the costs and benefits associated with future action. As is typical of studies of OFC function…media.tenor.coma close up of a woman 's face with the words look it 's complicated behind herALT: a close up of a woman 's face with the words look it 's complicated behind her 110
Stan Floresco @dr-stan.bsky.social · 01/12/2025What’s notable is that comparing this to previous studies where risk/reward decisions are guided by internal representations of action/outcome reward history (instead of external cues), these OFC regions play markedly different roles in guiding choice.media.tenor.coma man wearing a tie dye shirt says the two things are similar but they are not quite similarALT: a man wearing a tie dye shirt says the two things are similar but they are not quite similar 100
Stan Floresco @dr-stan.bsky.social · 01/12/2025Oh, BTW, when we inactivated the anterior agranular insular cortex adjacent to the lOFC, we found no changes in behaviormedia.tenor.coma man in a suit and tie with the words you have no effect on his faceALT: a man in a suit and tie with the words you have no effect on his face 100
Stan Floresco @dr-stan.bsky.social · 01/12/2025Whereas disrupting lOFC activity leads to a default in pursuing the larger rewards, even if this strategy is not always the most profitable strategy.media.tenor.coma picture of a man with a mustache and the words " more is not always better "ALT: a picture of a man with a mustache and the words " more is not always better " 110
Stan Floresco @dr-stan.bsky.social · 01/12/2025So both OFC regions are integral for guiding risk/reward decisions informed by cues that signal how likely certain actions may (or not) be rewarded, but do so in different way. The mOFC helps focus on the cues, in part by shaking off the impact of recent losses…media.tenor.coma man with a beard is sitting at a table with his hand on his chestALT: a man with a beard is sitting at a table with his hand on his chest 110
Stan Floresco @dr-stan.bsky.social · 01/12/2025In contrast, lateral OFC inactivation had the opposite increased risky choice irrespective of the odds the cues signaledmedia.tenor.coma man says never tell me the odds in front of a gold robotALT: a man says never tell me the odds in front of a gold robot 110
Stan Floresco @dr-stan.bsky.social · 01/12/2025This reduction in risky choice was associated with exaggerated focus smaller rewards and recent losses, even though on this task, they should have ignored this past information and focused on the cues in front of themmedia.tenor.coma man with a beard is wearing a green shirt that says you gotta work withALT: a man with a beard is wearing a green shirt that says you gotta work with 100
Stan Floresco @dr-stan.bsky.social · 01/12/2025HERE is where we saw differences! Inactivating medial OFC made rats risk aversemedia.tenor.coma man talking on a walkie talkie with the words you can 't take the risk above himALT: a man talking on a walkie talkie with the words you can 't take the risk above him 100