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Journal of Endocrinology

@joendocrinology.bsky.social
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The flagship journal of @socendocrinology.bsky.social Publishing basic and translational studies on endocrine physiology and metabolism. joe.bioscientifica.com

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Journal of Endocrinology @joendocrinology.bsky.social · 01/10/2026
A new review by Wenbiao Zhou et al. examines current evidence on environmental hormones and reproductive health, exploring their relationship with infertility, potential risks and clinical impacts, as well as future prospects and challenges in this evolving field. 🔗 doi.org/10.1530/JOE-26-0279
[Journal of Endocrinology logo]
A hidden crisis: the threat of environment to reproductive health
Wenbiao Zhou et al.
Graphical Abstract
J Endocrinol (2026) 270 (3): e260279. doi.org/10.1530/JOE-26-0279
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Journal of Endocrinology @joendocrinology.bsky.social · 29/09/2026
Does time-restricted feeding (TRF) reduce weight gain through LEAP2 inhibition? A new study investigated the effects of TRF on insulin and growth hormone profiles, glucose & lipid metabolism, and metabolic balance in high-fat diet-fed Leap2−/− mice. 🔗 Read the research: doi.org/10.1530/JOE-25-0416
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Journal of Endocrinology @joendocrinology.bsky.social · 24/09/2026
New research by Ambuj Shahi et al. investigates the effects of calcipotriol, a vitamin D receptor (VDR) agonist, on alcoholic steatohepatitis (ASH) progression in mice, demonstrating a role for calcipotriol as an endocrine-metabolic modulator of ASH. Read the research: doi.org/10.1530/JOE-26-0192
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Vitamin D receptor agonist calcipotriol protects against alcohol-induced hepatotoxicity in male mice. Ambuj Shahi, Abhishek Yadav, Rohit A Sinha, Mable M Singh, Pratik Medhe, Rukshana Mahamood, Anuj Kumar, Ashish Gupta.
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Journal of Endocrinology @joendocrinology.bsky.social · 17/09/2026
Could scutellarin represent a new treatment candidate for PCOS? New research by Zhi Li et al. explores the effects of scutellarin in a dehydroepiandrosterone (DHEA)-induced PCOS mouse model and in DHEA-treated human granulosa-like KGN cells. 🔗 doi.org/10.1530/JOE-25-0429
[Journal of Endocrinology logo] Scutellarin ameliorates PCOS in a mouse model by restoring mitochondrial function and inhibiting granulosa cell apoptosis Zhi Li, Xiaoping Yang, Weifen Deng, Yudong Liu, Peixuan Lan, Yibo Song, Yanqiu Xie, Yuhua Shi
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Journal of Endocrinology @joendocrinology.bsky.social · 15/09/2026
New research by Esam S. B. Salem et al. demonstrates that tubular mitochondrial Akt1 plays a key role in diabetic nephropathy progression. 🔗Read the research #OpenAccess: doi.org/10.1530/JOE-26-0143
[Journal of Endocrinology logo] Dual roles of renal tubular mitochondrial Akt1 in protecting against diabetic nephropathy and improving body glucose metabolism. Esam S. B. Salem et al. Figure 1. Bigenic mice (KMCAKT) for renal tubule-specific mitochondria-targeting constitutively active Akt1, and study design. A Mitochondrial-targeted constitutively active Akt1 (mcaAkt1) was engineered as described in the Methods section. A 6x His tag was fused in frame to the C-terminus of Akt1 cDNA. Mice harboring mcaAkt1 were crossed with KSP/CreERT2 mice to generate bi-transgenic mice (KMCAKT) for this study. B Eight-week-old KMCAKT mice were randomized into two groups – one injected with Tamoxifen (TAM) to induce expression of mcaAkt1 and the other with corn oil (CO) as a vehicle control. Each group was then subdivided into either a normal chow diet (NCD) with regular water or a high fat diet with fructose water (HFFD)...J Endocrinol JOE-26-0143. https://doi.org/10.1530/JOE-26-0143
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Journal of Endocrinology @joendocrinology.bsky.social · 10/09/2026
Could empagliflozin improve intestinal barrier integrity and gut microbiota profiles in T2DM? Using a high-fat diet/STZ-induced murine model of T2DM, new research by Ying Chang et al. investigates the impact of empagliflozin treatment in male C57BL/6 mice. 🔗 doi.org/10.1530/JOE-26-0110
[Journal of Endocrinology logo] 

Empagliflozin improves gut microbial disturbances and intestinal barrier integrity in STZ-induced type 2 diabetic mice 

Ying Chang, Yuanjiang Zhou, Fanlin Zhou, Jie Liang, Gangyi Yang, Peng Zhang, Mingyuan Tian 

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Journal of Endocrinology @joendocrinology.bsky.social · 08/09/2026
What role does adropin play in ovarian function? New research by Patrycja Kurowska et al. identifies adropin as a potential regulator of ovarian function, finding that adropin reduced human granulosa cell proliferation, cell cycle progression & promoted apoptosis. 🔗 doi.org/10.1530/JOE-25-0240
[Journal of Endocrinology logo] Adropin in polycystic ovarian syndrome: expression and impact on human granulosa cell function. Patrycja Kurowska, Monika Dawid, Natalia Respekta-Długosz, Julia Oprocha, Oliwia Szkraba, Marek Skrzypski, Noémie Couty, Christelle Ramé, Fabrice Guérif, Jakub Wyroba, Joanna Kochan, Lechosław Gajda, Monika Trzcińska, Joelle Dupont, Agnieszka Rak. [Graphical Abstract]
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Journal of Endocrinology @joendocrinology.bsky.social · 03/09/2026
New research investigates the therapeutic potential of IL-2/anti-IL-2 complex (IL-2C) & hyperbaric oxygen (HBO) therapy, both known to expand regulatory T cells (Tregs), in attenuating high-fat diet (HFD)-induced obesity & associated impairments in glucose metabolism. 🔗 doi.org/10.1530/JOE-25-0474
[Journal of Endocrinology logo]
Attenuation of diet-induced obesity and impaired glucose homeostasis by the IL-2/anti-IL-2 complex and hyperbaric oxygen
Eun-Jeong Choi, Hyung-Ran Kim, Jeong-Hae Kie, Ju-Young Seoh, Joo-Ho Lee
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Journal of Endocrinology @joendocrinology.bsky.social · 27/08/2026
What role does the mineralocorticoid receptor (MR) play in musculoskeletal health & bone crosstalk with other tissues? Husam Bensreti et al. examine the evidence on its role of genomic MR signaling in this latest review: doi.org/10.1530/JOE-24-0212
Exploring Osteoporosis and Sarcopenia (Osteosarcopenia) SPECIAL COLLECTION

Defining the potential role of the mineralocorticoid receptor in musculoskeletal health and bone crosstalk with other tissues Husam Bensreti et al.
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Journal of Endocrinology @joendocrinology.bsky.social · 25/08/2026
A new study builds on earlier findings that pharmacological inhibition of mTORC1 induces metabolic dysfunction-associated steatotic liver disease under normal conditions, providing new evidence supporting a critical role for ERRα in reversing MASLD. 🔗 Read the study: doi.org/10.1530/JOE-26-0176
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Rapamycin-induced fatty liver in mice is attenuated by chloroquine co-treatment in an ERRα-dependent manner. Wafa B’chir, Catherine R Dufour, Sylvia Andrzejewski, Julie St-Pierre, Charlotte Scholtes, Vincent Giguère
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Journal of Endocrinology @joendocrinology.bsky.social · 18/08/2026
Defining the contribution of 1,25(OH)2D3-mediated renal calcium reabsorption to systemic calcium balance and bone homeostasis. Using VdrRen- mice, a new study by Lieve Verlinden et al. examined the consequences of impaired renal VDR signalling. Read the article: doi.org/10.1530/JOE-26-0151
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Renal Vdr deletion drives urinary calcium loss with intestinal and skeletal compensatory responses
Lieve Verlinden, Stefanie Doms, Iris Janssens, Kayleigh Rillaerts, Geert Carmeliet, Brigitte Decallonne, Annemieke Verstuyf

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Journal of Endocrinology @joendocrinology.bsky.social · 11/08/2026
A new review reflects on key milestones in our understanding of the vitamin D receptor (VDR). This paper is the first paper in the special collection honouring David Mangelsdorf, whose work led to the successful cloning of the gene encoding the VDR. Read the full paper: doi.org/10.1530/JOE-26-0204
David J. Mangelsdorf: Orphan Nuclear Receptors, Endocrine Signalling, and Metabolic Discovery
SPECIAL COLLECTION
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The Vitamin D Receptor Story: Discovery, Control, and Genomic Reach
Mark B. Meyer, J. Wesley Pike

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Journal of Endocrinology @joendocrinology.bsky.social · 05/08/2026
How does ghrelin influence the effects of controlled ovarian hyperstimulation (COH) on preimplantation embryo development, implantation & decidual morpho-physiology? ND Ramírez et al. evaluate the effects of COH & its associated hyperghrelinemia on embryo development. 🔗 doi.org/10.1530/JOE-26-0041
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Ghrelin impairs embryo development after ovarian hyperstimulation
Nicolás David Ramírez, Martín Schulman Fernández, Pedro Javier Torres, Eugenia Mercedes Luque, María Sol Martínez, Verónica Cantarelli, Daniel Castrogiovanni, Marina Flavia Ponzio, Valeria Paola Carlini, Fernando Beltramone, Mario Perelló, Rubén Darío Motrich, Ana Carolina Martini

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Journal of Endocrinology @joendocrinology.bsky.social · 27/07/2026
New interim analysis data demonstrate an association between reductions in visceral fat area (VFA) and improved treatment response in patients undergoing fertility-sparing therapy for endometrial cancer (EC) or atypical endometrial hyperplasia (AEH). 🔗 doi.org/10.1530/JOE-25-0205
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Fertility-preserving therapy in EC/AEH: impact of weight and body fat changes, and interim analysis of a randomized trial
Qian Liu, Ying Cao, Dongyan Cao, Huimei Zhou, Mei Yu, Peng Peng, Tao Wang, Jiaxin Yang, Yuanli Feng
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Journal of Endocrinology @joendocrinology.bsky.social · 23/07/2026
New special collection provides a dedicated platform for research that advances understanding of the fundamental endocrine & molecular mechanisms through which endocrine diseases affect skeletal muscle metabolism. 🔗 journals.bioscientifica.com/joe/pages/skeletal-muscle-in-endocrinology-metabolism
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Integrative Perspectives on Skeletal Muscle in Endocrinology and Metabolism SPECIAL COLLECTION

Collection Editors:
Dr Mark C Turner
Assistant Professor in Endocrinology and Metabolism, Coventry University & Institute for Cardio-Metabolic Medicine, University Hospitals Coventry and Warwickshire

Dr Zaki Hassan-Smith
Clinical Associate Professor, Aston Medical School & Honorary Consultant Endocrinologist at University Hospitals Birmingham (UHB) NHS Foundation Trust
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Journal of Endocrinology @joendocrinology.bsky.social · 22/07/2026
Research by Micaela Inés Llanos Dumont et al. reveals steroid-dependent plasticity of hypothalamic astrocytes, supporting a key role for astrocyte–GnRH neuron interactions in the regulation of reproductive neuroendocrine function during gestation in plains vizcacha. 🔗 doi.org/10.1530/JOE-26-0001
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Relationship between hypothalamic astrocytes and gonadotropin-releasing hormone neurons in the female plains vizcacha. Micaela Inés Llanos Dumont, Alejandro Raúl Schmidt, Ileana Abigail Burd, Julia Halperin, Alfredo Daniel Vitullo, Verónica Berta Dorfman.
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Journal of Endocrinology @joendocrinology.bsky.social · 21/07/2026
🌐 We're proud to publish research that helps drive progress. Its influence is reflected in advances to endocrinology & strong research community engagement, reflected in our increased 2025 Impact Factor & continued CiteScore growth. 🔗 journals.bioscientifica.com/joe/pages/highly-cited-collection
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Journal of Endocrinology @joendocrinology.bsky.social · 14/07/2026
Exceptional visual contributions enhance research impact. At Journal of Endocrinology, we recognise such contributions through our Editors’ Choice Award. This quarter’s winner is Figure 3 in 'Bile acid metabolism: a potential node in the pathogenic network of PCOS' 🔗 doi.org/10.1530/JOE-25-0225
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Editors' Choice Figure Award Winner.

Bile acid metabolism: a potential node in the pathogenic network of PCOS.
Xinyi Wu, Wanzhen Li, Bingqi Wang, Min Wang.

Awarded by Co-Editors-in-Chief. Professor Ruth Andrew | Associate Professor Gabriela da Silva Xavier.

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Journal of Endocrinology @joendocrinology.bsky.social · 13/07/2026
We're delighted to recognise this quarter's Editors' Choice Award Winner: 'Caloric restriction exerts site-, sex-, and duration-dependent effects on skeletal structure and bone marrow adiposity' doi.org/10.1530/JOE-25-0391 Thanks to the authors for their contribution to endocrinology! 👏
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EDITORS' CHOICE WINNER

Caloric restriction exerts site-, sex-, and duration-dependent effects on skeletal structure and bone marrow adiposity
By Kuan-Chan Chen at al.

Awarded by Co-Editors-in-Chief
Professor Ruth Andrew
Associate Professor Gabriela da Silva Xavier

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Journal of Endocrinology @joendocrinology.bsky.social · 06/07/2026
New research by Chanisa Thonusin et al. explored the effects of the probiotic Lactobacillus reuteri KUB-AC5 on cardiac mitochondria in obesity, demostrating improvements in cardiac function and restored antioxidative capacity of cardiac mitochondria. 🔗 Read the research: doi.org/10.1530/JOE-...
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Probiotic Lactobacillus reuteri KUB-AC5 provides cardioprotection via mitigating cardiac mitochondrial dysfunction in obese rats.
By Chanisa Thonusin et al.

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Journal of Endocrinology @joendocrinology.bsky.social · 30/06/2026
New research by Dana María Negretti-Borga et al. suggests that the immunostimulatory effects of triiodothyronine (T3) on dendritic cells (DCs), and the driven adaptive immunity, are modulated by a complex sphingolipid-mediated signaling network. 🔗 Read the research: doi.org/10.1530/JOE-26-0081
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Triiodothyronine-driven pro-inflammatory responses of dendritic cells are restrained by sphingolipid signaling. By Dana Maria Negretti-Borga et al.

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Journal of Endocrinology @joendocrinology.bsky.social · 22/06/2026
New research by Zicheng Wang et al. demonstrates that downregulation of the solute carrier family 32 member 1 (SLC32A1), a GABA transporter protein, mediated PAI-1 pathway attenuates hepatic stellate cell activation and liver fibrosis. 🔗 Read the article: doi.org/10.1530/JOE-25-0300
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Downregulation of SLC32A1 mediates the PAI-1 pathway in alleviating hepatic stellate cell activation and liver fibrosis. By Zicheng Wang et al.

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Journal of Endocrinology @joendocrinology.bsky.social · 08/06/2026
New research by Yiwen Jiang et al. investigates the role of brain-derived membrane-initiated estrogen receptor-α (mERα) signalling in bone metabolism using a POMC-C451Af/f mouse model, in which mERα signalling is selectively inactivated in POMC-expressing neurons. 🔗 doi.org/10.1530/JOE-...
Membrane-initiated estrogen receptor-α signaling in the hypothalamus regulates trabecular bone in femur in female mice. By Yiwen Jiang et al.
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Figure 1. Increased bone mass and reduced adipose tissue in gonadal-intact female POMC-C451Af/f mice. Female POMC-C451Af/f and control mice were weighed (A), and body composition was measured by dual-energy X-ray absorptiometry at 5 and 16 weeks of age (two separate experiments), including total body areal bone mineral density; aBMD (B), total body lean mass (C), and total body fat percentage (D). At 16 weeks of age, gonadal fat (E), retroperitoneal fat (F), and uterus (G) were dissected and weighed. The femur and L5 vertebra were also collected and analyzed by high-resolution microcomputed tomography to assess femur trabecular bone volume fraction (BV/TV) (H), femur cortical thickness...

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Journal of Endocrinology @joendocrinology.bsky.social · 02/06/2026
🧬 How does CXCL13 contribute to obesity-related multi-organ complications? A new review by Mengke Huang et al. elucidates the pivotal role of C‑X‑C motif chemokine ligand 13 (CXCL13) in obesity-associated metabolic inflammation. Read the article #openaccess: doi.org/10.1530/JOE-25-0295
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The CXCL13 hub in obesity-related metabolic inflammation: regulation of spatiotemporal heterogeneity and targeted strategies. By Mengke Huang et al.

Figure 1. CXCL13 dynamically regulates the functions of three types of lymphoid structures: it maintains homeostatic architecture in SLOs, drives inflammatory ectopic aggregation in TLSs, and mediates the transition of fat-associated lymphoid clusters from physiological barrier protection to inflammatory immune responses. Journal of Endocrinology 269, 1; 10.1530/JOE-25-0295

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Journal of Endocrinology @joendocrinology.bsky.social · 29/05/2026
A new study by Kuan-Chan Chen et al. provides insight into the physiological function and role of bone marrow adipose tissue (BMAT) in caloric restriction (CR)–associated skeletal and metabolic health. 🔗 doi.org/10.1530/JOE-...
Caloric restriction exerts site-, sex-, and duration-dependent effects on skeletal structure and bone marrow adiposity. By Kuan-Chan Chen et al. 

 

Figure 7. Summary of CR’s duration-, sex-, and site-dependent effects on BMAT, bone, endocrine factors, and metabolic homeostasis. Outcomes are shown only if they are significantly influenced by CR. Numbers in yellow circles indicate the weeks of CR tested for each of the bone analyses. For each outcome (e.g. BMAT, bone, and endocrine/metabolic), duration-, site-, and sex-dependent effects are indicated only if these variables show significant interactions with diet (e.g. sex–diet, time–diet, location–diet) but not if these variables alone affect the outcome. For example, circulating adiponectin is higher in females than in males, regardless of diet, but CR increases adiponectin to a similar extent in both sexes; hence, there is no sex difference in this CR effect. An exception is where variables have more complex influences on the CR response, which are indicated as follows: * = CR has a duration-dependent effect in only one sex or that is stronger in one sex; # = sex difference in the CR effect is skeletal site dependent; ‡ = ANOVA shows no overall sex–diet interaction, but multiple comparisons show stronger CR effects in one sex. 

Journal of Endocrinology 269, 2; 10.1530/JOE-25-0391. 

 

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Journal of Endocrinology @joendocrinology.bsky.social · 20/05/2026
A new hot-topic review by Melissa Emily Wright, Aled Rees, and Kevin Murphy discusses how advanced neuroimaging applications could provide new insights into the pathophysiology of polycystic ovary syndrome (PCOS; recently renamed to PMOS). 🔗Read the review: doi.org/10.1530/JOE-...
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Endocrine Excellence: Discovery Science at SfE BES 2025 Special Collection.

Advanced neuroimaging in PCOS: state-of-the-art techniques and emerging trends. By Melissa E Wright, D Aled Rees, and Kevin Murphy.

Figure 1. Overview of potential PCOS-related mechanisms and emerging research neuroimaging themes. Journal of Endocrinology 269, 2; 10.1530/JOE-25-0421.
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Journal of Endocrinology @joendocrinology.bsky.social · 11/05/2026
New research by Amelia R Tanner (cupediatrics.bsky.social) et al. investigated the effects of 9 days of glucagon infusion (5 or 50 ng/kg/min) in late-gestation fetal sheep, increasing plasma glucagon concentrations by ~800% to study chronic fetal hyperglucagonemia. 🔗 doi.org/10.1530/JOE-25-0447
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New Research. Experimental chronic fetal hyperglucagonemia stimulates hepatic pathways for amino acid catabolism and gluconeogenesis. By Amelia R Tanner et al.

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Journal of Endocrinology @joendocrinology.bsky.social · 05/05/2026
🎉 Announcing the winner of the 2025 Best Paper Award 🎉 The 2025 Best Paper Award is presented to Désirée R Seib, Minseon M Jung, and Kiran K Soma for their paper: “Maternal sucrose consumption alters steroid levels in the mother, placenta and fetus” Huge congratulations to the authors!
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Journal of Endocrinology @joendocrinology.bsky.social · 29/04/2026
We celebrate impactful figures published in Journal of Endocrinology through our Editors' Choice Figure Award. The Q1 winner is Figure 3 in 'Clocks on steroids: how glucocorticoid receptors tell cells the time' By Anna Edmondson et al. 🔗 doi.org/10.1530/JOE-25-0340 Congratulations to the authors!
Editors' Choice Figure.

Clocks on steroids: how glucocorticoid receptors tell cells the time. By Anna Edmondson et al.

Figure 3
Transcriptional and non-transcriptional interactions between the GR and the circadian clock. Transcriptional interactions: i) GR-mediated transcriptional activation of PER1 and PER2 leading to an increase in PER1 and PER2 abundance (17, 26, 27, 41, 42, 43, 75). ii) Direct binding of the GR to CLOCK and BMAL1, which themselves bind to E-boxes upstream of NR1D1. Through tethering, the GR represses NR1D1, resulting in a decrease in REV-ERBa abundance (45, 46). iii) In a rhythmic fashion, CRY binds to the GR and represses the GR’s transcriptional activation activities (54). iv) CLOCK/BMAL1 acetylates the GR’s hinge region to suppress its transcriptional activities (32)...Journal of Endocrinology 269, 1; 10.1530/JOE-25-0340.

Paper picked by Journal of Endocrinology Co-Editors-in-Chief: Prof. Ruth Andrew and Associate Professor Gabriela da Silva Xavier.
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Journal of Endocrinology @joendocrinology.bsky.social · 29/04/2026
🏆 We're thrilled to award the Q1 Editors' Choice Award to: Fat’s all, folks: culturing and manipulating peri-prostatic adipocytes to probe impacts on prostate cancer biology By Nil Grunberg et al. 🔗 doi.org/10.1530/JOE-25-0256 Thanks to the authors for your outstanding contribution 👏
Editors' Choice Award. Journal of Endocrinology logo.

Fat’s all, folks: culturing and manipulating peri-prostatic adipocytes to probe impacts on prostate cancer biology. By Nil Grunberg et al.

Paper picked by Journal of Endocrinology Co-Editors-in-Chief:
Professor Ruth Andrew. Associate Professor Gabriela da Silva Xavier.
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Journal of Endocrinology @joendocrinology.bsky.social · 28/04/2026
New research by Qiong Wu et al. identifies numerous dysregulated lncRNAs through microarray analysis of human preadipocytes and differentiated adipocytes, with a focus on lncRNA521141 as a regulator of adipogenic differentiation. Read the research: doi.org/10.1530/JOE-...
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New Research. The impact and potential mechanisms of long noncoding RNA ENST00000521141.1 on human white adipocyte differentiation. By Qiong Wu et al.

Figure 1
Overexpression of lncRNA521141 does not affect the adipogenic capacity of human preadipocytes. (A) lncRNA521141 expression levels in human preadipocytes were assessed by qPCR on days 0, 1, 4, and 10 of the differentiation program (three biologically independent samples per time point). (B) Fluorescence microscopy was used to evaluate the transfection efficiency of the lncRNA521141 overexpression lentivirus (lnc-OV) and the negative control lentivirus (NC). (C). The overexpression efficiency of lncRNA521141 was confirmed by qPCR (three independent experiments). (D) The effect of lncRNA521141 overexpression on the morphology and lipid droplet size of human...Journal of Endocrinology 269, 1; 10.1530/JOE-25-0360.

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Journal of Endocrinology @joendocrinology.bsky.social · 15/04/2026
⏰ Glucocorticoids synchronise cellular circadian rhythms via canonical and rapid non‑canonical GR signalling, but the exact mechanism remains unclear. This review outlines current knowledge, key gaps, and how disrupted GC rhythms contribute to circadian‑linked disease. doi.org/10.1530/JOE-25-0340
New Review. Journal of Endocrinology logo.

Clocks on steroids: how glucocorticoid receptors tell cells the time. By Anna Edmondson et al.

Figure 3.Transcriptional and non-transcriptional interactions between the GR and the circadian clock. Transcriptional interactions: i) GR-mediated transcriptional activation of PER1 and PER2 leading to an increase in PER1 and PER2 abundance (17, 26, 27, 41, 42, 43, 75). ii) Direct binding of the GR to CLOCK and BMAL1, which themselves bind to E-boxes upstream of NR1D1. Through tethering, the GR represses NR1D1, resulting in a decrease in REV-ERBa abundance (45, 46). iii) In a rhythmic fashion, CRY binds to the GR and represses the GR’s transcriptional activation activities (54). iv) CLOCK/BMAL1 acetylates the GR’s hinge region to suppress its transcriptional activities (32)...Journal of Endocrinology 269, 1; 10.1530/JOE-25-0340

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Journal of Endocrinology @joendocrinology.bsky.social · 08/04/2026
A new study by Jinyuan Zhang et al. examines how TFF3 regulates lipotoxicity in male DKD mouse models. By investigating its effects on the AMPK/ACC & SCAP/SREBP signalling pathways, the study sheds light on the molecular mechanisms linking TFF3 to DKD progression. 🔗 doi.org/10.1530/JOE-25-0303
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New Research. TFF3 in Renal Pathobiology: A Novel Lipotoxicity Regulator in Male Mice with Diabetic Kidney Disease. By Jinyuan Zhang et al.

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Journal of Endocrinology @joendocrinology.bsky.social · 30/03/2026
Tmem119 has been shown to participate in the bone anabolic effects of PTH through the stimulation of osteoblastic bone formation in mice. A new study investigates Tmem119's role in PTH-enhanced bone repair after a femoral bone defect using Tmem119-deficient mice. 🔗 doi.org/10.1530/JOE-25-0375
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New Research. Tmem119 is involved in the bone repair enhanced by parathyroid hormone in female mice. By Ayaka Yamada et al.

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Journal of Endocrinology @joendocrinology.bsky.social · 26/03/2026
miR-200b-3p is linked to obesity, but understanding of its role in the pathogenesis of obesity remains limited. New research by Lang Qin et al. suggests that miR-200b-3p regulates adipocyte browning by targeting Prdm16 & could serve as a therapeutic target. 🔗 doi.org/10.1530/JOE-25-0131
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New Research. miR-200b-3p inhibits adipose browning by targeting Prdm16. By Lang Qin et al.

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Journal of Endocrinology @joendocrinology.bsky.social · 17/03/2026
🔎 A new study by Shinichiro Toyoda et al. examines how clinical hypoglycemia phenotypes may relate to the immunohistochemical expression of glucose transporters (GLUTs), glucokinase (GCK), and the glucagon‑like peptide‑1 receptor (GLP-1R) in insulinoma cells. 🔗 doi.org/10.1530/JOE-25-0134
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New Research. Insulinoma with postprandial hypoglycemia and characteristic expression of GLUT2/GCK/GLP-1R. By Shinichiro Toyoda et al.

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Journal of Endocrinology @joendocrinology.bsky.social · 10/03/2026
New study compares two major mouse models of estrogen loss - AROM KO (congenital) and OVX (adult‑onset). It highlights shared & distinct E2‑deficient traits, helping researchers choose the right model & offering a rich dataset for studying the effects of estrogen decline. 📄 doi.org/10.1530/JOE-...
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New Research. Congenital vs adult-onset estrogen deficiency in female mice: physiological effects and implications for therapy. By Ahmed K Aladhami et al.

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Diana Hofman, PhD candidate 🐠🦴🌈 @dwmhofman.bsky.social · 04/03/2026
Check out the first paper I contributed to!
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Journal of Endocrinology @joendocrinology.bsky.social · 02/03/2026
Triac is a thyroid hormone metabolite, with thyromimetic properties, present in sewage treatment plant effluents. New findings by Quinte F Geessinck raise an important question, could Triac act as an environmental endocrine disruptor? 📖 Read the research: doi.org/10.1530/JOE-25-0480
Journal of Endocrinology logo. 

New Research.
The thyroid hormone metabolite Triac stimulates bone mineralisation in larval zebrafish. 
By Quinte F Geessinck et al.

Published by Bioscientifica logo. 
80 Years 1946-2026 Society for Endocrinology logo.
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Journal of Endocrinology @joendocrinology.bsky.social · 24/02/2026
A new multi‑cohort analysis investigates how disrupted iron homeostasis & alterations in iron metabolism may link alcohol intake to hepatic injury. The study provides novel evidence that pure alcohol intake is significantly associated with liver steatosis and fibrosis. 🔗 doi.org/10.1530/JOE-25-0293
Journal of Endocrinology logo.

New Research. Iron homeostasis links the association between alcohol consumption and liver steatosis/fibrosis: a multi-cohort analysis. By Xin Zhang et al.

Graphical Abstract from https://doi.org/10.1530/JOE-25-0293

Published by Bioscientifica logo.
80 Years 1964-2026 Society for Endocrinology logo.
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Journal of Endocrinology @joendocrinology.bsky.social · 16/02/2026
A new study focuses on how the duration of PCOS influences hormonal profiles, bone metabolism, and bone’s microstructural and mechanical properties in the PCOS-induced mice model, providing insight into how the condition may alter skeletal integrity. Read the research: doi.org/10.1530/JOE-25-0292
Journal of Endocrinology logo.

New Research. 
Progressive impact of polycystic ovary syndrome on hormonal alterations, bone microarchitecture, and mechanical properties
By Sarita Pandey et al.

Published by Bioscientifica logo. 
80 Years 1946-2026 Society for Endocrinology logo.
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Journal of Endocrinology @joendocrinology.bsky.social · 09/02/2026
Recent research by Yuehui Zhang et al. identifies mitochondrial AR in the uterus and demonstrates that hyperandrogenism-induced, AR-dependent mitochondrial dysfunction in decidual stromal cells is a key mechanism underlying pregnancy loss in PCOS. Read the full study: doi.org/10.1530/JOE-...
Journal of Endocrinology logo. 

New Research. 
Mitochondrial AR overactivation coupled with uterine decidual mitochondrial defects in PCOS-associated pregnancy loss. 
By Yuehui Zhang et al.

Published by Bioscientifica logo. Society for Endocrinology logo.
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Journal of Endocrinology @joendocrinology.bsky.social · 02/02/2026
A new study by Nil Grunberg et al. outlines a protocol for ex vivo culture of fresh peri-prostatic adipose tissue (PPAT) and non-prostatic adipose tissue (NPAT), which reflects donor- and depot-specific characteristics. 🔓 doi.org/10.1530/JOE-25-0256
Journal of Endocrinology logo.

New Research
Fat’s all, folks: culturing and manipulating peri-prostatic adipocytes to probe impacts on prostate cancer biology. By Nil Grunberg et al.

Figure 1
Schematic overview of culturing fresh patient peri-prostatic adipose tissue and matched NPAT, isolation of SVF, in vitro differentiation of mature adipocytes and generation of novel immortalised pre-adipocyte cell lines. (i) PPAT and matched NPAT from robotic-assisted radical prostatectomy can be cultured (ii) ex vivo as explants for at least 96 h. (iii) Alternatively, cell-specific effects of mature adipocytes can be studied by isolating SVF and either (iv) culturing primary pre-adipocytes or (v) immortalising primary pre-adipocytes to generate patient-derived cell lines that represent donor- and depot-specific characteristics...Journal of Endocrinology 268, 1; 10.1530/JOE-25-0256

Published by Bioscientifica logo. 80 Years 1964-2026 Society for Endocrinology logo.
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Journal of Endocrinology @joendocrinology.bsky.social · 27/01/2026
Can leonurine, an alkaloid known for its anti-inflammatory & antioxidant properties, be effective in treating lung ischemia-reperfusion injury? New research by Wanying Chen et al. explores the therapeutic potential of LEO in a murine model. 🔓 Read the full article: doi.org/10.1530/JOE-25-0298
Journal of Endocrinology logo.
New Research: Leonurine alleviates lung ischemia–reperfusion injury through suppression of ferroptosis via RORα in male mice. By Wanying Chen et al.

Figure 1. Effect of LEO on LIRI in mice. (A) Representative H&E-stained images from murine lung tissues after lung ischemia–reperfusion injury (IR) and IR + LEO. Scale bar: 200 μm. (B) Fluorescent images of superoxide levels in murine lung tissues. Superoxide was determined with the fluorescent indicator DHE, and the fluorescent intensity of DHE was observed with a computer-assisted microscope. Scale bar: 200 μm. (C) The lung pathological damage score illustrating the extent of lung injury in different groups. (D) Quantification of the DHE staining in murine lung tissue from (C)...Journal of Endocrinology 268, 1; 10.1530/JOE-25-0298

Published by Bioscientifica logo. 80 Years 1946-2026 Society for Endocrinology logo.
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Journal of Endocrinology @joendocrinology.bsky.social · 22/01/2026
New study by Sharmilee Vetrivel et al. profiles primary bilateral macronodular adrenal hyperplasia (PBMAH) through immunohistochemistry, transcriptomics and exome analysis of 22 PBMAH patients who underwent adrenalectomy. Explore the research: doi.org/10.1530/JOE-...
Journal of Endocrinology logo. 

New Research. 

Immunohistochemistry-guided analyses of steroidogenesis in primary bilateral macronodular adrenal hyperplasia. By Sharmilee Vetrivel et al.

Published by Bioscientifica logo. Society for Endocrinology logo.
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Journal of Endocrinology @joendocrinology.bsky.social · 16/01/2026
We celebrate impactful figures published in Journal of Endocrinology through our Editors' Choice Figure Award. Our 2025 Q4 winner is Figure 5B in 'Estrogenic prevention of luteinizing hormone releasing hormone agonist-induced bone loss' By K V Wells et al. doi.org/10.1530/JOE-25-0315 Congrats!🎉
Editors' Choice Figure
Estrogenic prevention of luteinizing hormone releasing hormone agonist-induced bone loss. By K V Wells et al.
Figure 5
Estradiol, not DHT, supplementation restores LHRHa-induced trabecular and cortical bone loss... (B) Representative transverse μCT reconstruction images of distal femoral metaphysis (top), femoral middiaphysis (middle), and L5 vertebrae (bottom).
Journal of Endocrinology 267, 2; 10.1530/JOE-25-0315.
Paper picked by Journal of Endocrinology Co-Editors-in-Chief: Prof. Ruth Andrew and Associate Prof. Gabriela da Silva Xavier.
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Journal of Endocrinology @joendocrinology.bsky.social · 15/01/2026
🏆 We're thrilled to award this quarter's Editors' Choice Award to: Single-cell analysis of oxidative phosphorylation protein expression in pancreatic islets in type 2 diabetes. By Alana Mullins et al. doi.org/10.1530/JOE-25-0253 Thanks to the authors for your outstanding contribution 👏
Editors' Choice Award.

Single-cell analysis of oxidative phosphorylation protein expression in pancreatic islets in type 2 diabetes. By Alana Mullins et al. 

Paper pick by Journal of Endocrinology Co-Editors-in-Chief: Prof. Ruth Andrew and Associate Prof. Gabriela da Silva Xavier.

Journal of Endocrinology logo. Trophy icon.
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Journal of Endocrinology @joendocrinology.bsky.social · 12/01/2026
Sexual dimorphism shapes thyroid biology. A new review by Caroline C Faria et al. highlights how genetic, epigenetic and hormonal differences influence the entire thyroid axis, from central regulation to hormone metabolism. Explore the article: doi.org/10.1530/JOE-25-0346
Sex Effects in Endocrine Health and Disease. Special Collection.

Sex differences in thyroid function: from central regulation to hormone metabolism and disease susceptibility. By  Caroline C Faria et al.

Journal of Endocrinology logo.
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Journal of Endocrinology @joendocrinology.bsky.social · 02/01/2026
Can combined aerobic and resistance exercise improve sarcopenia in older patients with type 2 diabetes mellitus? A new randomised controlled trial by Yuxia Ma et al. reports encouraging improvements following intervention... Read the paper to learn more: doi.org/10.1530/JOE-25-0275
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New Research: Effects of combined aerobic and resistance exercise on sarcopenia in elderly patients with type 2 diabetes mellitus. By Yuxia Ma et al.

Published by Bioscientifica logo. Society for Endocrinology logo.
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Journal of Endocrinology @joendocrinology.bsky.social · 16/12/2025
💪New research by Thamires Siqueira de Oliveira et al. demonstrates that low‑dose thyroxine (T4) replacement does not improve muscle regeneration post-injury in elderly mice. Instead, T4 replacement therapy seemed to induce atrophy & tissue remodeling. doi.org/10.1530/JOE-25-0203
Exploring Osteoporosis and Sarcopenia Special Collection.

Thyroxine does not improve skeletal muscle regeneration after injury in aged mice. By Thamires Siqueira Oliveira et al.

Image is the Graphical Abstract from doi.org/10.1530/JOE-25-0203.

Journal of Endocrinology logo.
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