Journal of Endocrinology @joendocrinology.bsky.social · 01/10/2026A new review by Wenbiao Zhou et al. examines current evidence on environmental hormones and reproductive health, exploring their relationship with infertility, potential risks and clinical impacts, as well as future prospects and challenges in this evolving field. 🔗 doi.org/10.1530/JOE-26-0279 000
Journal of Endocrinology @joendocrinology.bsky.social · 29/09/2026Does time-restricted feeding (TRF) reduce weight gain through LEAP2 inhibition? A new study investigated the effects of TRF on insulin and growth hormone profiles, glucose & lipid metabolism, and metabolic balance in high-fat diet-fed Leap2−/− mice. 🔗 Read the research: doi.org/10.1530/JOE-25-0416 000
Journal of Endocrinology @joendocrinology.bsky.social · 24/09/2026New research by Ambuj Shahi et al. investigates the effects of calcipotriol, a vitamin D receptor (VDR) agonist, on alcoholic steatohepatitis (ASH) progression in mice, demonstrating a role for calcipotriol as an endocrine-metabolic modulator of ASH. Read the research: doi.org/10.1530/JOE-26-0192 000
Journal of Endocrinology @joendocrinology.bsky.social · 17/09/2026Could scutellarin represent a new treatment candidate for PCOS? New research by Zhi Li et al. explores the effects of scutellarin in a dehydroepiandrosterone (DHEA)-induced PCOS mouse model and in DHEA-treated human granulosa-like KGN cells. 🔗 doi.org/10.1530/JOE-25-0429 000
Journal of Endocrinology @joendocrinology.bsky.social · 15/09/2026New research by Esam S. B. Salem et al. demonstrates that tubular mitochondrial Akt1 plays a key role in diabetic nephropathy progression. 🔗Read the research #OpenAccess: doi.org/10.1530/JOE-26-0143 000
Journal of Endocrinology @joendocrinology.bsky.social · 10/09/2026Could empagliflozin improve intestinal barrier integrity and gut microbiota profiles in T2DM? Using a high-fat diet/STZ-induced murine model of T2DM, new research by Ying Chang et al. investigates the impact of empagliflozin treatment in male C57BL/6 mice. 🔗 doi.org/10.1530/JOE-26-0110 111
Journal of Endocrinology @joendocrinology.bsky.social · 08/09/2026What role does adropin play in ovarian function? New research by Patrycja Kurowska et al. identifies adropin as a potential regulator of ovarian function, finding that adropin reduced human granulosa cell proliferation, cell cycle progression & promoted apoptosis. 🔗 doi.org/10.1530/JOE-25-0240 022
Journal of Endocrinology @joendocrinology.bsky.social · 03/09/2026New research investigates the therapeutic potential of IL-2/anti-IL-2 complex (IL-2C) & hyperbaric oxygen (HBO) therapy, both known to expand regulatory T cells (Tregs), in attenuating high-fat diet (HFD)-induced obesity & associated impairments in glucose metabolism. 🔗 doi.org/10.1530/JOE-25-0474 000
Journal of Endocrinology @joendocrinology.bsky.social · 27/08/2026What role does the mineralocorticoid receptor (MR) play in musculoskeletal health & bone crosstalk with other tissues? Husam Bensreti et al. examine the evidence on its role of genomic MR signaling in this latest review: doi.org/10.1530/JOE-24-0212 000
Journal of Endocrinology @joendocrinology.bsky.social · 25/08/2026A new study builds on earlier findings that pharmacological inhibition of mTORC1 induces metabolic dysfunction-associated steatotic liver disease under normal conditions, providing new evidence supporting a critical role for ERRα in reversing MASLD. 🔗 Read the study: doi.org/10.1530/JOE-26-0176 000
Journal of Endocrinology @joendocrinology.bsky.social · 18/08/2026Defining the contribution of 1,25(OH)2D3-mediated renal calcium reabsorption to systemic calcium balance and bone homeostasis. Using VdrRen- mice, a new study by Lieve Verlinden et al. examined the consequences of impaired renal VDR signalling. Read the article: doi.org/10.1530/JOE-26-0151 030
Journal of Endocrinology @joendocrinology.bsky.social · 11/08/2026A new review reflects on key milestones in our understanding of the vitamin D receptor (VDR). This paper is the first paper in the special collection honouring David Mangelsdorf, whose work led to the successful cloning of the gene encoding the VDR. Read the full paper: doi.org/10.1530/JOE-26-0204 000
Journal of Endocrinology @joendocrinology.bsky.social · 05/08/2026How does ghrelin influence the effects of controlled ovarian hyperstimulation (COH) on preimplantation embryo development, implantation & decidual morpho-physiology? ND Ramírez et al. evaluate the effects of COH & its associated hyperghrelinemia on embryo development. 🔗 doi.org/10.1530/JOE-26-0041 000
Journal of Endocrinology @joendocrinology.bsky.social · 27/07/2026New interim analysis data demonstrate an association between reductions in visceral fat area (VFA) and improved treatment response in patients undergoing fertility-sparing therapy for endometrial cancer (EC) or atypical endometrial hyperplasia (AEH). 🔗 doi.org/10.1530/JOE-25-0205 000
Journal of Endocrinology @joendocrinology.bsky.social · 23/07/2026New special collection provides a dedicated platform for research that advances understanding of the fundamental endocrine & molecular mechanisms through which endocrine diseases affect skeletal muscle metabolism. 🔗 journals.bioscientifica.com/joe/pages/skeletal-muscle-in-endocrinology-metabolism 021
Journal of Endocrinology @joendocrinology.bsky.social · 22/07/2026Research by Micaela Inés Llanos Dumont et al. reveals steroid-dependent plasticity of hypothalamic astrocytes, supporting a key role for astrocyte–GnRH neuron interactions in the regulation of reproductive neuroendocrine function during gestation in plains vizcacha. 🔗 doi.org/10.1530/JOE-26-0001 000
Journal of Endocrinology @joendocrinology.bsky.social · 21/07/2026🌐 We're proud to publish research that helps drive progress. Its influence is reflected in advances to endocrinology & strong research community engagement, reflected in our increased 2025 Impact Factor & continued CiteScore growth. 🔗 journals.bioscientifica.com/joe/pages/highly-cited-collection 000
Journal of Endocrinology @joendocrinology.bsky.social · 14/07/2026Exceptional visual contributions enhance research impact. At Journal of Endocrinology, we recognise such contributions through our Editors’ Choice Award. This quarter’s winner is Figure 3 in 'Bile acid metabolism: a potential node in the pathogenic network of PCOS' 🔗 doi.org/10.1530/JOE-25-0225 000
Journal of Endocrinology @joendocrinology.bsky.social · 13/07/2026We're delighted to recognise this quarter's Editors' Choice Award Winner: 'Caloric restriction exerts site-, sex-, and duration-dependent effects on skeletal structure and bone marrow adiposity' doi.org/10.1530/JOE-25-0391 Thanks to the authors for their contribution to endocrinology! 👏 010
Journal of Endocrinology @joendocrinology.bsky.social · 06/07/2026New research by Chanisa Thonusin et al. explored the effects of the probiotic Lactobacillus reuteri KUB-AC5 on cardiac mitochondria in obesity, demostrating improvements in cardiac function and restored antioxidative capacity of cardiac mitochondria. 🔗 Read the research: doi.org/10.1530/JOE-... 000
Journal of Endocrinology @joendocrinology.bsky.social · 30/06/2026New research by Dana María Negretti-Borga et al. suggests that the immunostimulatory effects of triiodothyronine (T3) on dendritic cells (DCs), and the driven adaptive immunity, are modulated by a complex sphingolipid-mediated signaling network. 🔗 Read the research: doi.org/10.1530/JOE-26-0081 000
Journal of Endocrinology @joendocrinology.bsky.social · 22/06/2026New research by Zicheng Wang et al. demonstrates that downregulation of the solute carrier family 32 member 1 (SLC32A1), a GABA transporter protein, mediated PAI-1 pathway attenuates hepatic stellate cell activation and liver fibrosis. 🔗 Read the article: doi.org/10.1530/JOE-25-0300 000
Journal of Endocrinology @joendocrinology.bsky.social · 08/06/2026New research by Yiwen Jiang et al. investigates the role of brain-derived membrane-initiated estrogen receptor-α (mERα) signalling in bone metabolism using a POMC-C451Af/f mouse model, in which mERα signalling is selectively inactivated in POMC-expressing neurons. 🔗 doi.org/10.1530/JOE-... 010
Journal of Endocrinology @joendocrinology.bsky.social · 02/06/2026🧬 How does CXCL13 contribute to obesity-related multi-organ complications? A new review by Mengke Huang et al. elucidates the pivotal role of C‑X‑C motif chemokine ligand 13 (CXCL13) in obesity-associated metabolic inflammation. Read the article #openaccess: doi.org/10.1530/JOE-25-0295 000
Journal of Endocrinology @joendocrinology.bsky.social · 29/05/2026A new study by Kuan-Chan Chen et al. provides insight into the physiological function and role of bone marrow adipose tissue (BMAT) in caloric restriction (CR)–associated skeletal and metabolic health. 🔗 doi.org/10.1530/JOE-... 110
Journal of Endocrinology @joendocrinology.bsky.social · 20/05/2026A new hot-topic review by Melissa Emily Wright, Aled Rees, and Kevin Murphy discusses how advanced neuroimaging applications could provide new insights into the pathophysiology of polycystic ovary syndrome (PCOS; recently renamed to PMOS). 🔗Read the review: doi.org/10.1530/JOE-... 021
Journal of Endocrinology @joendocrinology.bsky.social · 11/05/2026New research by Amelia R Tanner (cupediatrics.bsky.social) et al. investigated the effects of 9 days of glucagon infusion (5 or 50 ng/kg/min) in late-gestation fetal sheep, increasing plasma glucagon concentrations by ~800% to study chronic fetal hyperglucagonemia. 🔗 doi.org/10.1530/JOE-25-0447 000
Journal of Endocrinology @joendocrinology.bsky.social · 05/05/2026🎉 Announcing the winner of the 2025 Best Paper Award 🎉 The 2025 Best Paper Award is presented to Désirée R Seib, Minseon M Jung, and Kiran K Soma for their paper: “Maternal sucrose consumption alters steroid levels in the mother, placenta and fetus” Huge congratulations to the authors! 030
Journal of Endocrinology @joendocrinology.bsky.social · 29/04/2026We celebrate impactful figures published in Journal of Endocrinology through our Editors' Choice Figure Award. The Q1 winner is Figure 3 in 'Clocks on steroids: how glucocorticoid receptors tell cells the time' By Anna Edmondson et al. 🔗 doi.org/10.1530/JOE-25-0340 Congratulations to the authors! 010
Journal of Endocrinology @joendocrinology.bsky.social · 29/04/2026🏆 We're thrilled to award the Q1 Editors' Choice Award to: Fat’s all, folks: culturing and manipulating peri-prostatic adipocytes to probe impacts on prostate cancer biology By Nil Grunberg et al. 🔗 doi.org/10.1530/JOE-25-0256 Thanks to the authors for your outstanding contribution 👏 000
Journal of Endocrinology @joendocrinology.bsky.social · 28/04/2026New research by Qiong Wu et al. identifies numerous dysregulated lncRNAs through microarray analysis of human preadipocytes and differentiated adipocytes, with a focus on lncRNA521141 as a regulator of adipogenic differentiation. Read the research: doi.org/10.1530/JOE-... 030
Journal of Endocrinology @joendocrinology.bsky.social · 15/04/2026⏰ Glucocorticoids synchronise cellular circadian rhythms via canonical and rapid non‑canonical GR signalling, but the exact mechanism remains unclear. This review outlines current knowledge, key gaps, and how disrupted GC rhythms contribute to circadian‑linked disease. doi.org/10.1530/JOE-25-0340 000
Journal of Endocrinology @joendocrinology.bsky.social · 08/04/2026A new study by Jinyuan Zhang et al. examines how TFF3 regulates lipotoxicity in male DKD mouse models. By investigating its effects on the AMPK/ACC & SCAP/SREBP signalling pathways, the study sheds light on the molecular mechanisms linking TFF3 to DKD progression. 🔗 doi.org/10.1530/JOE-25-0303 000
Journal of Endocrinology @joendocrinology.bsky.social · 30/03/2026Tmem119 has been shown to participate in the bone anabolic effects of PTH through the stimulation of osteoblastic bone formation in mice. A new study investigates Tmem119's role in PTH-enhanced bone repair after a femoral bone defect using Tmem119-deficient mice. 🔗 doi.org/10.1530/JOE-25-0375 000
Journal of Endocrinology @joendocrinology.bsky.social · 26/03/2026miR-200b-3p is linked to obesity, but understanding of its role in the pathogenesis of obesity remains limited. New research by Lang Qin et al. suggests that miR-200b-3p regulates adipocyte browning by targeting Prdm16 & could serve as a therapeutic target. 🔗 doi.org/10.1530/JOE-25-0131 000
Journal of Endocrinology @joendocrinology.bsky.social · 17/03/2026🔎 A new study by Shinichiro Toyoda et al. examines how clinical hypoglycemia phenotypes may relate to the immunohistochemical expression of glucose transporters (GLUTs), glucokinase (GCK), and the glucagon‑like peptide‑1 receptor (GLP-1R) in insulinoma cells. 🔗 doi.org/10.1530/JOE-25-0134 000
Journal of Endocrinology @joendocrinology.bsky.social · 10/03/2026New study compares two major mouse models of estrogen loss - AROM KO (congenital) and OVX (adult‑onset). It highlights shared & distinct E2‑deficient traits, helping researchers choose the right model & offering a rich dataset for studying the effects of estrogen decline. 📄 doi.org/10.1530/JOE-... 000
Reposted by Journal of EndocrinologyDiana Hofman, PhD candidate 🐠🦴🌈 @dwmhofman.bsky.social · 04/03/2026Check out the first paper I contributed to! 011
Journal of Endocrinology @joendocrinology.bsky.social · 02/03/2026Triac is a thyroid hormone metabolite, with thyromimetic properties, present in sewage treatment plant effluents. New findings by Quinte F Geessinck raise an important question, could Triac act as an environmental endocrine disruptor? 📖 Read the research: doi.org/10.1530/JOE-25-0480 000
Journal of Endocrinology @joendocrinology.bsky.social · 24/02/2026A new multi‑cohort analysis investigates how disrupted iron homeostasis & alterations in iron metabolism may link alcohol intake to hepatic injury. The study provides novel evidence that pure alcohol intake is significantly associated with liver steatosis and fibrosis. 🔗 doi.org/10.1530/JOE-25-0293 010
Journal of Endocrinology @joendocrinology.bsky.social · 16/02/2026A new study focuses on how the duration of PCOS influences hormonal profiles, bone metabolism, and bone’s microstructural and mechanical properties in the PCOS-induced mice model, providing insight into how the condition may alter skeletal integrity. Read the research: doi.org/10.1530/JOE-25-0292 000
Journal of Endocrinology @joendocrinology.bsky.social · 09/02/2026Recent research by Yuehui Zhang et al. identifies mitochondrial AR in the uterus and demonstrates that hyperandrogenism-induced, AR-dependent mitochondrial dysfunction in decidual stromal cells is a key mechanism underlying pregnancy loss in PCOS. Read the full study: doi.org/10.1530/JOE-... 000
Journal of Endocrinology @joendocrinology.bsky.social · 02/02/2026A new study by Nil Grunberg et al. outlines a protocol for ex vivo culture of fresh peri-prostatic adipose tissue (PPAT) and non-prostatic adipose tissue (NPAT), which reflects donor- and depot-specific characteristics. 🔓 doi.org/10.1530/JOE-25-0256 000
Journal of Endocrinology @joendocrinology.bsky.social · 27/01/2026Can leonurine, an alkaloid known for its anti-inflammatory & antioxidant properties, be effective in treating lung ischemia-reperfusion injury? New research by Wanying Chen et al. explores the therapeutic potential of LEO in a murine model. 🔓 Read the full article: doi.org/10.1530/JOE-25-0298 000
Journal of Endocrinology @joendocrinology.bsky.social · 22/01/2026New study by Sharmilee Vetrivel et al. profiles primary bilateral macronodular adrenal hyperplasia (PBMAH) through immunohistochemistry, transcriptomics and exome analysis of 22 PBMAH patients who underwent adrenalectomy. Explore the research: doi.org/10.1530/JOE-... 000
Journal of Endocrinology @joendocrinology.bsky.social · 16/01/2026We celebrate impactful figures published in Journal of Endocrinology through our Editors' Choice Figure Award. Our 2025 Q4 winner is Figure 5B in 'Estrogenic prevention of luteinizing hormone releasing hormone agonist-induced bone loss' By K V Wells et al. doi.org/10.1530/JOE-25-0315 Congrats!🎉 000
Journal of Endocrinology @joendocrinology.bsky.social · 15/01/2026🏆 We're thrilled to award this quarter's Editors' Choice Award to: Single-cell analysis of oxidative phosphorylation protein expression in pancreatic islets in type 2 diabetes. By Alana Mullins et al. doi.org/10.1530/JOE-25-0253 Thanks to the authors for your outstanding contribution 👏 000
Journal of Endocrinology @joendocrinology.bsky.social · 12/01/2026Sexual dimorphism shapes thyroid biology. A new review by Caroline C Faria et al. highlights how genetic, epigenetic and hormonal differences influence the entire thyroid axis, from central regulation to hormone metabolism. Explore the article: doi.org/10.1530/JOE-25-0346 010
Journal of Endocrinology @joendocrinology.bsky.social · 02/01/2026Can combined aerobic and resistance exercise improve sarcopenia in older patients with type 2 diabetes mellitus? A new randomised controlled trial by Yuxia Ma et al. reports encouraging improvements following intervention... Read the paper to learn more: doi.org/10.1530/JOE-25-0275 000
Journal of Endocrinology @joendocrinology.bsky.social · 16/12/2025💪New research by Thamires Siqueira de Oliveira et al. demonstrates that low‑dose thyroxine (T4) replacement does not improve muscle regeneration post-injury in elderly mice. Instead, T4 replacement therapy seemed to induce atrophy & tissue remodeling. doi.org/10.1530/JOE-25-0203 022