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Sean McKenzie

@dorylophile.bsky.social
130 followers 115 following 6 posts
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Reposted by Sean McKenzie
Christine He @christinehe.bsky.social · 02/05/2026
Released today: ~1.5 Tbp of ONT metagenomic sequencing from compost. Assembly, MAGs, and downstream analysis are available to play with epi2me.nanoporetech.com/compost_mgx_...
epi2me.nanoporetech.com
Metagenomic Assembly Sheds Light on Microbial Diversity in Compost
Overview We are pleased to release a metagenomic dataset from deep sequencing of a mature compost…
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Reposted by Sean McKenzie
Jim Shaw @jimshaw.bsky.social · 27/03/2026
Myloasm, our long-read metagenome assembler, is now published! w/ @mgmarin.bsky.social and @lh3lh3.bsky.social Very rewarding after > a year of development and countless hours thinking about assembly. Thanks to beta testers, Li lab, and reviewers who gave very helpful feedback. rdcu.be/famFj
rdcu.be
High-resolution metagenome assembly for modern long reads with myloasm
Nature Biotechnology - A long-read metagenome assembly method recovers circular and complete genomes better than existing tools.
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Sean McKenzie @dorylophile.bsky.social · 24/03/2026
New tool from Heng Li lab, offering amazing accuracy for SVs even in low complexity regions (also incredible SNPs/Indels for a deeplearning-free approach)
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Reposted by Sean McKenzie
Hugo Darras @hugodarras.bsky.social · 06/02/2026
The most satisfying genome assembler to run, ever. Huge appreciation for the team behind hifiasm 👏
doi.org
Efficient near-telomere-to-telomere assembly of nanopore simplex reads - Nature
A genome assembly method called hifiasm (ONT) allows the assembly of chromosomes from telomere to telomere without the need for ultra-long reads, and outperforms conventional methods on most evaluatio...
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Reposted by Sean McKenzie
Oxford Nanopore @nanoporetech.com · 04/12/2025
We can’t wait to welcome you back to Old Billingsgate! Early bird tickets for London Calling 2026 are now available to purchase! Buy yours before 1st Jan and be a part of the biggest Oxford #Nanopore sequencing event of the year. Click here for tickets: bit.ly/4ouoqzR
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Reposted by Sean McKenzie
Fritz Sedlazeck @sedlazeck.bsky.social · 10/11/2025
plsRT: Looking for a motivated postdoc! Join us at @bcmhgsc.bsky.social to explore the mosaic & somatic landscape of the human genome: structural variants, methylation, and all things @smahtnetwrk.bsky.social If you like long reads, complex variants & methylation come talk to me!
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Reposted by Sean McKenzie
Fritz Sedlazeck @sedlazeck.bsky.social · 27/10/2025
Trio-barcoded @nanoporetech.com Adaptive Sampling (TBAS) to improve #RareDisease diagnostic at less than 1/2 the $$ & high cov: 76% solve rate across 13 trios inc. two corrections from prev. diagnosis. www.medrxiv.org/content/10.1... @gregor-research.bsky.social @bcmhgsc.bsky.social #Research
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Reposted by Sean McKenzie
Ryan Wick @rrwick.bsky.social · 29/09/2025
Happy to share that the paper describing Autocycler is now 100% up: doi.org/10.1093/bioi... (1/3)
doi.org
Autocycler: long-read consensus assembly for bacterial genomes
AbstractMotivation. Long-read sequencing enables complete bacterial genome assemblies, but individual assemblers are imperfect and often produce sequence-l
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Reposted by Sean McKenzie
Christine He @christinehe.bsky.social · 27/08/2025
ONT has a temporary bioinformatics position (8 months) open while I'm on maternity leave. Focus will be on microbial genomics but with opportunities to work on projects across the breadth of genomics! ejnh.fa.em2.oraclecloud.com/hcmUI/Candid...
ejnh.fa.em2.oraclecloud.com
Applications Bioinformatician (8 month temporary role)
We are looking for an individual with expertise in bioinformatics and data analysis, specializing in microbial genomics and metagenomics, to join our Applications team as an Applications Bioinformatic...
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Sean McKenzie @dorylophile.bsky.social · 10/06/2025
Usually avoid politics on bluesky, but PBS is a particularly special cause for me: The House will vote this week on a massive cut to public media funding. Your local stations are at risk. Call your Rep. now and urge them to vote NO before it’s too late. bit.ly/3T68Qgw #ProtectMyPublicMedia
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Sean McKenzie @dorylophile.bsky.social · 25/04/2025
It's been a good month for Nanopore assembly preprints! This time metagenomic assembly with nanoMDBG: hundreds of high-quality MAGs from high-complexity communities
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Sean McKenzie @dorylophile.bsky.social · 18/04/2025
Exciting preprint from Haoyu Cheng (not on bluesky?) and @lh3lh3.bsky.social: building amazing Nanopore assemblies just got faster and more accessible! Thrilled to have played a small part in this work!
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Sean McKenzie @dorylophile.bsky.social · 19/12/2024
Check out our new Apps Note on metagenomic assembly of the Zymo fecal reference with nanopore sequencing and metaMDBG. Almost 200 Gb of metagenomic sequence data from a single PromethION flowcell, yeilding hundreds of high-quality metagenome assembled genomes: nanoporetech.com/resource-cen...
nanoporetech.com
Application note: Oxford Nanopore sequencing provides superior MAG recovery and strain-level resolution from a complex microbiome | Oxford Nanopore Technologies
In this application note, we demonstrate the capabilities of Oxford Nanopore metagenomics by sequencing and analysing the well-characterised ZymoBIOMICS Fecal Reference.
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