Reposted by Laura Donlin
Congratulations to IMP student Ian Mantel @ianmunology.bsky.social in the lab of Dr Laura Donlin on their study highlighting a specific macrophage subset that remodels the arthritic niche during disease progression. @science.org
www.science.org/doi/10.1126/...
science.org
SPP1hi macrophages in fibrin niches promote hyperplastic tissue remodeling in rheumatoid arthritis synovium
SPP1hi macrophages in synovial fibrin deposits promote tissue hyperplasia in the joints of individuals with rheumatoid arthritis.