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rantao2023.bsky.social

@rantao2023.bsky.social

Reposted by @rantao2023.bsky.social

Scientific Writer @ CENOS St. Jude Children's Research Hospital @sjcenos.bsky.social · 15/05/2025

The Northcott lab identified inherited ELP1 loss increases risk for SHH #medulloblastoma through stalled differentiation, DNA replication stress, genomic instability, and accelerated cell cycle. Restoring p53 signaling was found to have therapeutic potential. tinyurl.com/5355xy6t

tinyurl.com

Study reveals targetable mechanism behind high-risk predisposition gene in pediatric medulloblastoma

Uncover how ELP1 gene defects drive pediatric brain cancer—and learn how that revealed MDM2 inhibition as a targeted therapy to restore tumor suppressor p53.

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Reposted by @rantao2023.bsky.social

Scientific Writer @ CENOS St. Jude Children's Research Hospital @sjcenos.bsky.social · 12/02/2025

The proteosome fine-tunes protein levels; defects in targeted degradation cause disease, such as mutations in KBTBD4 driving medulloblastoma. Investigators at UW, Harvard, and St. Jude identified these mutations create interactions with new protein targets to aberrantly degrade them.

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rantao2023.bsky.social @rantao2023.bsky.social · 13/02/2025

Honored to contribute to this study! Excited to see the impact of our work.

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rantao2023.bsky.social @rantao2023.bsky.social · 07/01/2025

Thrilled to share our recent work published in @naturegenet.bsky.social, where we uncover how ZIC1 is regulated by distinct genetic and epigenetic mechanisms in SHH vs. Group 4 medulloblastoma—revealing it as a context-dependent driver. tinyurl.com/2c3jnhn2

tinyurl.com

ZIC1 is a context-dependent medulloblastoma driver in the rhombic lip - Nature Genetics

Analysis of medulloblastomas in humans and mice shows that the functional consequences of ZIC1 mutations are exquisitely dependent on the cells of origin that give rise to different subgroups of medul...

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