Thrilled to share a huge piece of my PhD! 🎉 We show how replicated chromosomes maintain sister chromatid cohesion while still actively folding loops within nested TAD hierarchy.
Read the full paper here: link.springer.com/article/10.1... 🧬👇
link.springer.com
Nested TAD hierarchy defines cohesion zones on replicated chromosomes - The EMBO Journal
During each cell cycle, cells must not only duplicate the DNA sequence but also preserve the three-dimensional genome architecture required for gene regulation and DNA repair. After replication, this ...