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David Michonneau

@dmichonneau.bsky.social
64 followers 130 following 16 posts

MD, PhD, hematologist @hopitalsaintlouis.bsky.social Professor of hematology @upcite.bsky.social @INSERM @institut-leucemie.bsky.social UMR1342 www.institut-leucemie.fr/linstitut-…

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David Michonneau @dmichonneau.bsky.social · 05/05/2026
Merci à @alexandradelbot.bsky.social et @franceculture.fr pour cette éclairage sur la réaction du greffon contre l’hôte et sur les enjeux de l’allogreffe de CSH, qui vulgarise parfaitement notre article paru dans @science.org (doi.org/10.1126/scit...) www.radiofrance.fr/francecultur...
radiofrance.fr
Greffe de moelle osseuse : quand le nouveau système immunitaire s'emballe
Après une greffe de moelle osseuse, 6 patients sur 10 développent la maladie du greffon contre l'hôte. Le seul traitement possible, les corticoïdes, échoue dans la moitié des cas. Une étude révèle que...
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David Michonneau @dmichonneau.bsky.social · 08/04/2026
New in @science.org 🧬 Thrilled to share our last paper Corticosteroid resistance is predetermined by early immune response dynamics at acute graft-versus-host disease onset | Science Translational Medicine #ScienceTranslationalMedicineResearch www.science.org/doi/10.1126/...
science.org
Corticosteroid resistance is predetermined by early immune response dynamics at acute graft-versus-host disease onset
Steroid-resistant acute graft-versus-host disease is set at disease onset and leads to distinct cell-to-cell cross-talk and immune trajectories.
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David Michonneau @dmichonneau.bsky.social · 05/11/2025
Happy to share our article in collaboration with @leeat-keren.bsky.social at Weizmann Institute of Science and @institut-leucemie.bsky.social A spatial atlas of human gastrointestinal acute GVHD reveals epithelial and immune dynamics underlying disease pathophysiology www.science.org/doi/10.1126/...
science.org
A spatial atlas of human gastrointestinal acute GVHD reveals epithelial and immune dynamics underlying disease pathophysiology
Multiplexed imaging of aGVHD GI biopsies revealed epithelial remodeling and alteration in immune composition, offering insight into disease pathology.
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David Michonneau @dmichonneau.bsky.social · 10/07/2025
doi.org/10.1084/jem.... Great collaboration with the group of Robert Zeiser linking microbiota-derived metabolites and central nervous system GVHD
doi.org
Gut microbiota–derived TMAVA is a modulator of acute CNS-GVHD
In this study, we report that microbiota depletion exacerbates acute graft-versus-host disease in the central nervous system, driven by microglial activati
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David Michonneau @dmichonneau.bsky.social · 19/06/2025
www.nature.com/articles/s41...
nature.com
Diet outperforms microbial transplant to drive microbiome recovery in mice - Nature
Experiments in mouse models show that proper recovery of the intestinal microbiota following depletion, with or without faecal microbiota transplant therapy, is dependent on syntrophic interactions th...
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David Michonneau @dmichonneau.bsky.social · 16/04/2025
Great collaboration with Robert Zeiser @institut-leucemie.bsky.social @upcite.bsky.social @ap-hp.bsky.social @insermpresse.bsky.social Teduglutide for treatment-refractory severe intestinal acute graft-versus-host disease - a multicenter survey @springernature.com @BMT journal rdcu.be/ehWV5
rdcu.be
Teduglutide for treatment-refractory severe intestinal acute graft-versus-host disease - a multicenter survey
Bone Marrow Transplantation - Teduglutide for treatment-refractory severe intestinal acute graft-versus-host disease - a multicenter survey
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David Michonneau @dmichonneau.bsky.social · 01/04/2025
Happy to share our last paper, published with @springernature.com in @BMTjournal, about the French experience with belumosudil in the treatment of steroid-resistant cGvHD. Best ORR 57.4% including 14.7% of CR in patients who previously received at least 2 LOT rdcu.be/efZg9
rdcu.be
Efficacy and safety of belumosudil for treatment of cGVHD: multicenter retrospective analysis of the French cohort of the compassionate use program, on behalf of the French Society of Bone Marrow Transplantation and Cellular Therapy
Bone Marrow Transplantation - Efficacy and safety of belumosudil for treatment of cGVHD: multicenter retrospective analysis of the French cohort of the compassionate use program, on behalf of the...
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David Michonneau @dmichonneau.bsky.social · 14/02/2025
Congratulations to Sophie Le Grand for her very interesting paper in Hemasphere about the role of HLA evolutionary divergence score to predict outcome of prophylactic donor lymphocyte infusion after alloHSCT doi.org/10.1002/hem3...
doi.org
HLA evolutionary divergence score after donor lymphocyte infusion following allogeneic hematopoietic stem cell transplantation
Donor lymphocyte infusion (DLI) prevents acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) relapses following hematopoietic stem cell transplantation. Given the life-threatening toxiciti....
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David Michonneau @dmichonneau.bsky.social · 20/01/2025
Systems-level immunomonitoring in children with solid tumors to enable precision medicine: Cell www.cell.com/cell/fulltex...
cell.com
Systems-level immunomonitoring in children with solid tumors to enable precision medicine
In a population-based cohort of 191 children with diverse solid tumors, systems-level analyses unravel immune variation with age and tumor type and provide a reference for future precision immunothera...
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