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Davide Giampiccolo

@dgiampiccolo.bsky.social
64 followers 46 following 18 posts

Neurosurgeon | National Hospital for Neurology and Neurosurgery, Queen Square, London | UCL Queen Square Institute of Neurology

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Davide Giampiccolo @dgiampiccolo.bsky.social · 17/02/2025
9/ Finally, thank you so much to @EpilepsyInst to support this work! 🔗 Read the full article in @brain1878.bsky.social : www.researchgate.net/publication/... #neuroscience #brain #executivecontrol #neuroanatomy
researchgate.net
(PDF) The inferior fronto-occipital fasciculus: bridging phylogeny, ontogeny and functional anatomy
PDF | The inferior-fronto-occipital fasciculus is a long-range white matter tract that connects the prefrontal cortex with parietal, posterior temporal... | Find, read and cite all the research you ne...
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Davide Giampiccolo @dgiampiccolo.bsky.social · 17/02/2025
8/ We believe this work offers new insights into the IFOF’s role beyond semantics and invites further exploration into its broad executive functions.
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Davide Giampiccolo @dgiampiccolo.bsky.social · 17/02/2025
7/ Clinically, this pathway’s importance in neurosurgery is clear: it should be considered a key target for preservation in both hemispheres (against the myth of a non-dominant right hemisphere).
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Davide Giampiccolo @dgiampiccolo.bsky.social · 17/02/2025
6/ This unified view links language, visual processing, motor cognition, theory of mind, reading, attention, and emotion recognition—grounding cognitive control in top-down modulation of visual features. It also posits a role for the right IFOF in social semantic control.
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Davide Giampiccolo @dgiampiccolo.bsky.social · 17/02/2025
5/ Using stimulation, we propose it can be subdivided in two-layers: 🔹 Ventral IFOF: Cognitive control for conceptual/symbolic content (including language). 🔹 Dorsal IFOF: Cognitive control for perceptual content
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Davide Giampiccolo @dgiampiccolo.bsky.social · 17/02/2025
4/ We propose that the IFOF overlays cortical regions involved in semantic control and the multiple demand system, representing an executive, prefrontal connection for top-down modulation of visual features. It is language-sensitive, but not language-specific.
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Davide Giampiccolo @dgiampiccolo.bsky.social · 17/02/2025
3/ Our review challenges the idea that the IFOF evolved for language. Gathered data indicate that this pathway is present along the primate lineage—far earlier than language—suggesting it originally supported top-down cognitive control of visual features for goal-directed behaviour.
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Davide Giampiccolo @dgiampiccolo.bsky.social · 17/02/2025
2/ Since then, the IFOF has been considered the major anatomical pathway linking language to meaning, but objections have emerged suggesting its function goes beyond language.
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Davide Giampiccolo @dgiampiccolo.bsky.social · 17/02/2025
1/ Almost 20 years ago, we reported that the IFOF supports language semantics through causal, direct stimulation [Duffau et al., Brain (2005)]. This work laid the foundation for understanding its role in the ventral stream of language. academic.oup.com/brain/articl...
academic.oup.com
New insights into the anatomo-functional connectivity of the semantic system: a study using cortico-subcortical electrostimulations
Abstract. Despite a better understanding of the organization of the cortical network underlying the semantic system, very few data are currently available
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Davide Giampiccolo @dgiampiccolo.bsky.social · 17/02/2025
🧵 Excited to share our latest review, published in @brain1878.bsky.social, on the inferior fronto-occipital fasciculus (IFOF)! @ucl.ac.uk – paper at the end of the thread:
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Davide Giampiccolo @dgiampiccolo.bsky.social · 17/02/2025
7/ Clinically, this pathway’s importance in neurosurgery is clear: it should be considered a key target for preservation in both hemispheres (against the myth of a non-dominant right hemisphere).
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Davide Giampiccolo @dgiampiccolo.bsky.social · 17/02/2025
6/ This unified view links language, visual processing, motor cognition, theory of mind, reading, attention, and emotion recognition—grounding cognitive control in top-down modulation of visual features. It also posits a role for the right IFOF in social semantic control.
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Davide Giampiccolo @dgiampiccolo.bsky.social · 17/02/2025
5/ Using stimulation we propose it can be subdivided in two-layers: 🔹 Ventral IFOF: Cognitive control for conceptual/symbolic content (including language). 🔹 Dorsal IFOF: Cognitive control for perceptual content.
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Davide Giampiccolo @dgiampiccolo.bsky.social · 17/02/2025
4/ We propose that the IFOF overlays cortical regions involved in semantic control and the multiple demand system, representing an executive, prefrontal connection for top-down modulation of sensory features. It is language-sensitive, but not language-specific.
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Davide Giampiccolo @dgiampiccolo.bsky.social · 17/02/2025
3/ Our review challenges the idea that the IFOF evolved for language. Gathered data indicate that this pathway is present along the primate lineage—far earlier than language—suggesting it originally supported top-down cognitive control of visual features for goal-directed behaviour.
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Davide Giampiccolo @dgiampiccolo.bsky.social · 17/02/2025
2/ Since then, the IFOF has been considered the major anatomical pathway linking language to meaning, but objections have emerged suggesting its function goes beyond language.
100
Davide Giampiccolo @dgiampiccolo.bsky.social · 17/02/2025
1/ Almost 20 years ago, we reported that the IFOF supports language semantics through causal, direct stimulation [Duffau et al., Brain (2005)]. This work laid the foundation for understanding its role in the ventral stream of language. academic.oup.com/brain/articl...
academic.oup.com
New insights into the anatomo-functional connectivity of the semantic system: a study using cortico-subcortical electrostimulations
Abstract. Despite a better understanding of the organization of the cortical network underlying the semantic system, very few data are currently available
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Reposted by Davide Giampiccolo
Laurent Sheybani @laurentsheybani.bsky.social · 13/02/2025
A new study in Brain Comms included 84 people with epilepsy due to hippocampal sclerosis and 43 controls to test how structural abnormalities shape verbal memory. @dgiampiccolo.bsky.social @braincomms.bsky.social doi.org/10.1093/brai...
doi.org
Cortico-hippocampal networks underpin verbal memory encoding in temporal lobe epilepsy
In this cross-sectional study of 84 hippocampal sclerosis patients and 43 healthy controls, Fiore et al. linked verbal learning variability to cortical and
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Davide Giampiccolo @dgiampiccolo.bsky.social · 22/01/2025
So well deserved, @aabjamjoom.bsky.social . Really, sky is the limit!
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Reposted by Davide Giampiccolo
Laurent Sheybani @laurentsheybani.bsky.social · 17/01/2025
How does memory evolve after epilepsy surgery? For the better it seems! --> doi.org/10.1038/s414... @uclqsion.bsky.social @dgiampiccolo.bsky.social
doi.org
Long-term memory plasticity in a decade-long connectivity study post anterior temporal lobe resection - Nature Communications
Using functional MRI, the authors tracked memory recovery over a decade after epilepsy surgery, revealing key brain changes in spared medial temporal structures and contralateral regions, highlighting...
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