iiinova — where your digital self keeps evolving

Chris Deppmann @deppmann.bsky.social · 14/09/2026

Born 90 years ago today: Ferid Murad, son of an Albanian teenager who sold candy across the Balkans, spoke seven languages on under a year of schooling, and was renamed at Ellis Island. At UVA in the 1970s the son worked out why nitroglycerin stops angina: it releases nitric oxide. Nobel, 1998.

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Chris Deppmann @deppmann.bsky.social · 26/08/2026

The Molecule Hunters is now a podcast — We Are Biochemistry season 2, new episode every 2 days: open.spotify.com/show/6gUAeZTYYRPzdAc84Lj4Gt The Kindle edition is now free: amazon.com/dp/B0HF9MWSHK Also: audiobook open.spotify.com/show/76t8SyjmvJWec5fTjT3mYd · textbook biochemistrypedia.com

open.spotify.com

We Are Biochemistry: The Science That Connects Us

Podcast · 1233414575 · "We Are Biochemistry: The Science That Connects Us" explores life's molecular world. This 3000-level equivalent podcast covers key topics: biomolecules, metabolism, genetic engi...

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Chris Deppmann @deppmann.bsky.social · 20/08/2026

Every lesson also has a panel on the people behind it. The kinetics one has Fischer, Michaelis, Menten, and Koshland. That is the same instinct that produced The Molecule Hunters, the history-of-biochemistry book my students wrote. Also free. deppmannlab.com/book

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Chris Deppmann @deppmann.bsky.social · 20/08/2026

Follow up to the book post: there is a companion textbook, and it is free too. Biochemistrypedia comes out of years of teaching a large biochem course at UVA. Thirty lessons, no account, nothing to install. Drag Vmax and Km and watch the curve move. biochemistrypedia.com

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Chris Deppmann @deppmann.bsky.social · 17/08/2026

It's free. The full PDF and EPUB are on our site, and the audiobook, about eleven hours, is free on Spotify. It will be free in most outlets. Amazon charges $3 for the Kindle right now and I'm working on getting that to zero as well. deppmannlab.com/book Hope you enjoy it.

lnkd.in

This link will take you to a page that’s not on LinkedIn

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Chris Deppmann @deppmann.bsky.social · 17/08/2026

This is something that didn't exist, and now it exists (with lots of help from Claude et al). This is a book I wanted to read and I'm happy with how it turned out. I love thinking about science through the personalities of the discoverers.

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Chris Deppmann @deppmann.bsky.social · 17/08/2026

Here is how it got made. Last spring I gave my biochemistry students an AI assisted extra-credit project: pick a scientist, do the deep research, write a profile. Then about six months of editing from Abbie and I. More than 500 students are co-authors.

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Chris Deppmann @deppmann.bsky.social · 17/08/2026

We self-published a history of biochemistry book. The Molecule Hunters is 133 profiles of the people who decoded life, from a physician weighing a willow tree in the 1640s to structural biologists predicting protein folds with AI. 190 scientists, eleven parts, four centuries.

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Chris Deppmann @deppmann.bsky.social · 09/01/2025

Congrats to Sushanth Kumar on his first corresponding author paper in Glia! 🎉👏 Using single-cell mass cytometry—like doing Western blots for every individual cell—this study maps the unique signaling signatures of microglia during viral and bacterial infections. doi.org/10.1002/glia...

doi.org

Characterizing Microglial Signaling Dynamics During Inflammation Using Single‐Cell Mass Cytometry

Microglia play a critical role in maintaining central nervous system (CNS) homeostasis and display remarkable plasticity in their response to inflammatory stimuli. However, the specific signaling pro....

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Reposted by Chris Deppmann

Ali D. Güler @aguler.bsky.social · 18/12/2024

GLP-1 receptor agonists (GLP-1RAs) are transforming the treatment of obesity and diabetes (and more). Our recent pre-print examined next-gen small molecules mimicking GLP-1, using humanized mouse models to uncover how they interact with brain circuits driving food consumption. 1/15

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Chris Deppmann @deppmann.bsky.social · 18/12/2024

Huge congrats to Lizzy et al for showing how next-gen GLP1R drugs hack your amygdala to make your dopamine neurons say 'nah' to that second slice! 🧠🍰❌ Another great collab with @aguler.bsky.social 🔥"https://www.biorxiv.org/content/10.1101/2024.12.12.628169v1

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Chris Deppmann @deppmann.bsky.social · 18/12/2024

Exciting news from our lab! Amy, Eli, and the team just published a single-cell mass cytometry atlas of the developing mouse brain! 🧠 24M cells profiled, 85 unique clusters identified—shedding light on protein-level cell state dynamics. Congrats, team! rdcu.be/d30MN

rdcu.be

A single-cell mass cytometry-based atlas of the developing mouse brain

Nature Neuroscience - In recent years, valuable mRNA-based developmental atlases of the mouse brain have been made available. Here, the authors use single-cell mass cytometry to build a...

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Reposted by Chris Deppmann

Watanabe Lab @JHU @watanabelab.bsky.social · 02/12/2024

Excited to share our latest findings, now published @NatureNeuro www.nature.com/articles/s41... We found unmyelinated axons exhibit pearls-on-a-string morphology's due to their membrane mechanical properties. Threads will follow!

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