iiinova — where your digital self keeps evolving

David Entenberg @dentenberg.bsky.social · 9h

We're hiring! Join our team at Einstein to study breast cancer metastasis and the tumor microenvironment. We're looking for a cancer biologist to drive multidisciplinary work using mouse models, advanced imaging, and microfluidics in NYC. 🧬🧫🔬 www.linkedin.com/jobs/view/44...

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David Entenberg @dentenberg.bsky.social · 20/04/2026

We're hiring! Join our team at Einstein and put your computational imaging skills to work where it really matters: improving outcomes for cancer patients. Come join a multidisciplinary team in NYC that's pushing science from bench to bedside. 🔬 www.linkedin.com/jobs/view/44...

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David Entenberg @dentenberg.bsky.social · 25/01/2026

Huge congratulations to first author Mohd Nauman and all the co-authors and collaborators who made this story possible! @cdi-einstein.bsky.social @einsteinmededu.bsky.social @monteeinsteinpath.bsky.social

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David Entenberg @dentenberg.bsky.social · 25/01/2026

Taken together, the data support a model where stemness sits at the top of a hierarchy, controlling at least two separable programs: a MenaINV-dependent extravasation module and a MenaINV-independent survival module, both needed for efficient lung colonization.

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David Entenberg @dentenberg.bsky.social · 25/01/2026

Later on, when these non-stem cells go on to form metastases, they acquire stemness!

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David Entenberg @dentenberg.bsky.social · 25/01/2026

Knocking out MenaINV in stem cells eliminates their ability to extravasate into lung tissue, but their survival advantage remains. Adding MenaINV to non-stem cells makes them suddenly become much more capable of crossing the endothelium.

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David Entenberg @dentenberg.bsky.social · 25/01/2026

A key player here is MenaINV, an invasive isoform of the actin regulator Mena that we and others have linked to tumor cell intravasation and extravasation. We show that cancer stem cells express more MenaINV, and that turns out to be central to their metastatic advantage.

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David Entenberg @dentenberg.bsky.social · 25/01/2026

Using a intravital imaging of a fluorescent reporter for stemness, we track individual stem cells in the living lung and find that they do not just show up more often, they are intrinsically better at both getting out of lung blood vessels and staying alive once they do.

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David Entenberg @dentenberg.bsky.social · 25/01/2026

Super excited to share our latest work, now out as a preprint on bioRxiv! In this one, we ask a simple question with big implications: how do breast cancer stem cells gain such a huge edge during early lung metastasis? www.biorxiv.org/content/10.6...

Cancer stem cells (yellow) and non-stem cells (red) that have exited the blood vessels inside the live lung.

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Reposted by David Entenberg

Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · 02/10/2025

Great @cdi-einstein.bsky.social seminar by Jose Javier Bravo Cordero from @mountsinainyc.bsky.social covering ECM architecture, metabolism and neuroscience. Fantastic work! Thanks for visiting us!

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Reposted by David Entenberg

Montefiore Einstein Pathology @monteeinsteinpath.bsky.social · 03/09/2025

Metastasis drives most #breastcancer deaths. A new study led by Dr. Rachel Hazan of Einstein shows how the Wnt/ERK/CDK4/6 pathway fuels the growth of aggressive hybrid tumor cells. Blocking it slowed tumor growth and reduced aggressiveness. In British J of Cancer tinyurl.com/5xpscst6 #metasasis

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David Entenberg @dentenberg.bsky.social · 29/08/2025

Great go see this finally come out! Exciting work! Congratulations!

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David Entenberg @dentenberg.bsky.social · 05/08/2025

Please join me in congratulating the newly minted Dr. Madeline Friedman DeLuca! She did a phenomenal job in her thesis defense today! #ProudPI @cdi-einstein.bsky.social @einsteinmededu.bsky.social @monteeinsteinpath.bsky.social

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David Entenberg @dentenberg.bsky.social · 26/03/2025

Congratulations Neta! !מזל טוב

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David Entenberg @dentenberg.bsky.social · 20/03/2025

Got to hear the amazing Miriam Merad talk today. Fantastic work she's doing understanding how to better target tumor associated macrophages!

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David Entenberg @dentenberg.bsky.social · 15/03/2025

WR-JSHS? I heard that they are trying to get it back for next year.

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David Entenberg @dentenberg.bsky.social · 15/03/2025

What a fantastic day of science! Those were amazing projects!

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David Entenberg @dentenberg.bsky.social · 15/03/2025

Super excited to hear all the great student research at #WESEF (the second largest science fair in the country). My list, just 7 of the nearly 800 projects being presented today, shows how students are helping to fight sickle cell disease, lung cancer, and inflammatory bowel disease.

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David Entenberg @dentenberg.bsky.social · 17/02/2025

Just finished reviewing grants for study section. Quick question for other reviewers. What do you read first when reviewing a grant? Coment on your favorite method and why. 1️⃣ Abstract/Narrative 2️⃣️ Specific Aims 3️⃣ Research Strategy 4️⃣ Biosketches 5️⃣ Straight through like a book 📊 Show results

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David Entenberg @dentenberg.bsky.social · 16/02/2025

Oh my! So glad to see you're trying it out the protocol and fighting metastasis. If you haven't, check out our JoVE video. We introduced a few new tools to make the surgery easier. app.jove.com/v/62761/a-pe... Good luck. Reach out if you have any questions! Looking forward to seeing your videos!

app.jove.com

A Permanent Window for Investigating Cancer Metastasis to the Lung

Watch this Scientific Journal Video about A Permanent Window for Investigating Cancer Metastasis to the Lung at JoVE.com

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David Entenberg @dentenberg.bsky.social · 14/02/2025

So excited to share the latest work from the amazing Serena Lucotti and the rest of the David Lyden Lab out now in Cell. Super honored to have been able to help out in this great work! news.weill.cornell.edu/news/2025/02... www.cell.com/cell/abstrac...

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David Entenberg @dentenberg.bsky.social · 11/02/2025

For your favorite AI... Worked well in Perplexity. My zip code is XXXXX. Look up who my senators are and who my representative in the house is and write separate letters to them urging them to oppose the NIH cuts to indirect costs. Talk about how it will be damaging to science and to the country.

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David Entenberg @dentenberg.bsky.social · 11/02/2025

Please write to your representatives in congress asking them to oppose the cuts in NIH funding. Whether you think that limiting overhead is good or bad, drastically cutting funding in such a short time span is destructive. If this stands, the negative impact on science will be felt for generations.

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David Entenberg @dentenberg.bsky.social · 01/02/2025

Our findings point to another way in which tumor associated macrophages help cancer cells escape and spread. But our findings also suggest that microenvironment-based therapies, like blocking macrophage repolarization, may reduce the pro-metastatic side effects of NAC in breast cancer.

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David Entenberg @dentenberg.bsky.social · 01/02/2025

increase in macrophage-tumor cell NF-kB/ Notch1 signaling, which results in MenaINV induction. Blocking the Notch pathway during paclitaxel treatment stops this effect.

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David Entenberg @dentenberg.bsky.social · 01/02/2025

One way this happens is through the increase in MenaINV, a protein tumor cells use to get in and out of blood vessels in the breast and the lung. In this new work investigated what may cause this increase. We find that NAC causes a re-polarization of tumor-associated macrophages. This leads to an

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David Entenberg @dentenberg.bsky.social · 01/02/2025

Neoadjuvant chemotherapy (NAC) helps shrink tumors and extend the lives of many breast cancer patients. That is clear. However, a few years ago we and others discovered that in some cases, neoadjuvant paclitaxel may have an unwanted side effect where dissemination is inadvertently increased.

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David Entenberg @dentenberg.bsky.social · 05/01/2025

Seems like a modern day version of Night on Earth.

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David Entenberg @dentenberg.bsky.social · 05/01/2025

Haven't seen it yet, but it's on my list!

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David Entenberg @dentenberg.bsky.social · 06/11/2023

Ready to help lead breast cancer mestastasis research? Come join our translational team. Role is majority research, but with significant lab management as well. The Researcher & Lab Manager is a person who will be integral to our leadership team! www.linkedin.com/jobs/view/37...

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