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Dr David Joffe MB BS(Hons), PhD, FRACP

@davidjoffe64.bsky.social
13K followers 532 following 4.9K posts

Respiratory and Sleep Medicine Neurobiology and Long Cövid Vice President of ISLC & PAIS

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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 2h
The micro-Tesla stuff is proof of concept. Helpful for demonstrating a pathway.... Not going to be a mainstream Rx.
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 6h
I would also be keen to hear more about availability and pricing 🙏🏻
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 6h
My apologies.... It's a reference from a movie Translation: those that respond think you're a genius. Reality: It was luck not much else. I'm a fan of probiotics. I don't foresee any obvious down sides. It seemed well tolerated. I'm not sure about cost. I would be personally interested in that 😎
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 11h
I'm never keen to dismiss a therapy. This is a solid study undertaken by excellent people. It's good science Will it be helpful for all? "Rule of Thirds" 1/3 = zero response at any dose 1/3 = Love you Long Time 1/3 = Terrible side-effects @putrinolab.bsky.social
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 06/10/2026
Then there's this from the Italian Group. Presented in Amsterdam at a session I was lucky enough to be chairing 😎 pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov
VSL#3® supplementation improves fatigue in long COVID: results from the DELong#3 randomized placebo-controlled trial
Long COVID is frequently characterized by persistent fatigue and impaired quality of life. Increasing evidence suggests that gut microbiota dysbiosis and immune dysregulation may contribute to symptom...
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 06/10/2026
The best study thus far is with BA-21 Mexican study
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 06/10/2026
😇👍🏻
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 06/10/2026
Cite this article Herrera, E., Señoráns, A., Barrenechea, A. et al. Cognitive phenotypes and neuropsychological trajectories in post-COVID-19 syndrome: a 12-month follow-up study. Sci Rep (2026). doi.org/10.1038/s415...
doi.org
Cognitive phenotypes and neuropsychological trajectories in post-COVID-19 syndrome: a 12-month follow-up study - Scientific Reports
Scientific Reports - Cognitive phenotypes and neuropsychological trajectories in post-COVID-19 syndrome: a 12-month follow-up study
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 06/10/2026
I agree... I try my best to post an operational link 🤦🏻‍♂️
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 06/10/2026
🧠 Daily Feed of Brain Damage 🧠 @atranscendedman.bsky.social 🙏🏻 doi.org/10.1038/s415...
doi.org
Cognitive phenotypes and neuropsychological trajectories in post-COVID-19 syndrome: a 12-month follow-up study - Scientific Reports
Scientific Reports - Cognitive phenotypes and neuropsychological trajectories in post-COVID-19 syndrome: a 12-month follow-up study
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 06/10/2026
doi.org/10.1016/j.cr...
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 05/10/2026
For those following this substantial medical conundrum... And... For those following this account Thank you 😊🙏🏻 doi.org/10.1155/jimr...
doi.org
Characterizing Host Inflammatory Bioprofiles in People With Postacute Sequelae SARS‐CoV‐2 Infection (PASC)
Postacute sequelae of COVID-19 or “PASC” is a common but heterogeneous condition associated with significant morbidity. Although its pathogenesis remains poorly understood, proposed underlying mechan...
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 04/10/2026
🧠 Daily Feed of Brain Damage 🧠 doi.org/10.1016/j.bb...
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 03/10/2026
🧠 Daily Feed of Brain Damage 🧠 doi.org/10.1016/j.bb...
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 03/10/2026
😂😂🤦🏻‍♂️
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 03/10/2026
I'm still there for the science. The politics is algorithmic. The trolling is vile. I don't post much except really to colleagues and within niche DM Groups
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 03/10/2026
🧐... Thank you 👍🏻
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 03/10/2026
You just gotta love a company so fucked up, they cannot find your email to re-instate your prior account... BUT... They can find you when @elonmusk needs my $Au12... What a Shit Head 😂😂
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 03/10/2026
I'm not the Person to follow for a pile of shits and giggles... Thank you for sharing 🙏🏻 I appreciate the understanding and yep... I'm here for those with an interest and concerns
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 03/10/2026
Insomnia in Long Cövid isn't your friend 😔😔 doi.org/10.1016/j.ce...
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 03/10/2026
Apologies... Scientists 🙏🏻
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 02/10/2026
Great forED... But you still need your Professional Labs for all the consequences. Add-ons are common. Like ABG's... The wards outside of ED and ICU still send them to central command. You cannot run these without serious Lab Techs.
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 02/10/2026
These .... And other questions 🤷🏻‍♂️
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 02/10/2026
🙏🏻👍🏻
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 02/10/2026
There's a plethora of science about the virus and acute illness and consequences The cut-off point for the diagnosis of LC is arbitrary at 3 months. That's not the clinical reality. Some seem okay until they are not. Some never recover from the initial insult. Many are unwell but don't seek help
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 02/10/2026
😂😂😂 I will forever think of the Beach Boys "Good Vibrations" when I hear of this syndrome.... Long story 😊
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 02/10/2026
Ummmm.... So just when you thought your Long Covid was bad? "Orgasmic Cephalgia" enters the chat😳 doi.org/10.1093/sxmr...
doi.org
Post-orgasmic illness syndrome: possible role of mast cells, immunoglobulins, and multi-organ system inflammatory response
AbstractIntroduction. Post-orgasmic Illness Syndrome (POIS) is an incapacitating reaction that erupts following ejaculation/orgasm. The reaction occurs in
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 02/10/2026
"77.4% continued to meet PCC criteria in 2024" doi.org/10.1038/s415...
doi.org
Factors associated with persistent post-COVID-19 condition and functional limitation four years after SARS-CoV-2 infection - Scientific Reports
Scientific Reports - Factors associated with persistent post-COVID-19 condition and functional limitation four years after SARS-CoV-2 infection
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 01/10/2026
And my colleagues wonder why I protest in favour of masks in Health Care 😔💔 doi.org/10.1136/bmj-...
doi.org
Covid-19: 40% of affected healthcare workers had long covid, and a quarter still had symptoms after a year
Four in ten healthcare workers worldwide who were infected with SARS-CoV-2 during the pandemic developed long covid, and a quarter still had symptoms after a year, a report has found. The report by t...
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 30/09/2026
doi.org/10.3390/path...
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 29/09/2026
link.springer.com/article/10.1...
link.springer.com
Health-related quality of life in IBD patients with long COVID under China’s normalized COVID-19 management - BMC Infectious Diseases
Introduction Although the COVID pandemic has gradually subsided, many patients have experienced complicated long-term symptoms, collectively known as “long-COVID”, which is commonly associated with pe...
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 29/09/2026
Adebisi et al. Tropical Medicine and Health (2026) 54:214 doi.org/10.1186/s411...
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 27/09/2026
The UK lull is definitely over. Cases are rising in a number of places. It's likely that community immunity has waned, although there's also a new kid on the block. It's difficult for even the best mutant trackers to bed sure with sparse testing and uploading of sequences
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 27/09/2026
🧠 Daily Feed of Brain Damage 🧠 Part 2 The gift that keeps giving 👀 doi.org/10.1038/s415...
doi.org
Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction - Nature Medicine
A national prospective study of patients requiring hospitalization for COVID-19 demonstrates global cognitive deficits at 1 year, associated with elevated brain injury markers and reduced gray matter ...
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 27/09/2026
You're absolutely right, Steve🙏🏻😊 My apologies... The puppies were having a bath... Chaos ensued 😂😂
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 27/09/2026
Shit‼️ My BAD🤦🏻‍♂️ Take ...#2 www.mdpi.com/2077-0383/15...
mdpi.com
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 27/09/2026
🧠 Daily Feed of Brain Damage 🧠 In case you're wondering why people have "attitude" and anger issues 😳 doi.org/10.3390/neur...
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 27/09/2026
Useful paper. Consider hypocarbia when you see POTS. At least it's a treatment responsive cause of breathlessness👍🏻 www.mdpi.com/2077-0383/15...
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 26/09/2026
And then.... There's Measles 🤦🏻‍♂️ doi.org/10.1016/j.ce...
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 24/09/2026
Metabolic derangement following acute infection... Possibly a predictor of LC going forward. Only COVID causes Long C-19 doi.org/10.1016/j.di...
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 23/09/2026
Things that don't improve over time pubs.rsna.org/doi/10.1148/...
pubs.rsna.org
Five-year Quantitative Chest CT and Hyperpolarized Xenon 129 Ventilation MRI Findings in Survivors of COVID-19 Pneumonia | Radiology
Five years after COVID-19 pneumonia, some survivors showed persistent respiratory symptoms, abnormal diffusion capacity, and ventilation defects, with stabilization of pulmonary function and chest ...
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 22/09/2026
Elegant study from @profmarkfaghy.bsky.social and his outstanding Team.... Now in ink🖋😎 doi.org/10.1093/oxfi...
doi.org
An Open-Label Feasibility Study of Remdesivir in Long COVID: Results from the ERASE LC Trial
AbstractObjective. Treatment of acute COVID-19 with anti-viral and immunomodulator medications demonstrates a reduced risk of long-term outcomes. To date,
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 21/09/2026
When you don't bother with precautions in Health Care doi.org/10.1002/ajim...
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 21/09/2026
The AAA in the UK said the rude bit out loud in 2024... "Accidents have increased in 2023... Your premiums are going up" Minns -NSW Premier "Lockdowns caused accidents because we forgot how to drive... Fines are going up" 😂🤦🏻‍♂️
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 21/09/2026
Sorry... I'm not the "Good News" Guy 😔
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 21/09/2026
It's certainly pause for thought isn't it? The metric I find most useful is motor vehicle and heavy industry accidents. At a time of ever safer cars and increased regulatory oversight... There's more road rage and serious accidents. Air Traffic Controllers are another worth watching
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 21/09/2026
🧠 Daily Feed of Brain Damage 🧠 doi.org/10.1016/j.yn...
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 19/09/2026
Clever little virus www.science.org/doi/10.1126/...
science.org
Secreted ORF8 reprograms macrophages to enhance SARS-CoV-2 infection of lung epithelial cells
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily targets the respiratory epithelium, yet severe disease features diffuse lung injury and hyperinflammatory syndromes driven by dys...
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 17/09/2026
🧐🧐.... Hmmmmm 🙏🏻
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 17/09/2026
Without comment 👇🏻👇🏻
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