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David Finlay @davidfinlaytcd.bsky.social · 22/05/2026

What they do use iron for: 🔹 mitochondrial Fe-S proteins 🔹 heme-containing proteins → targeted allocation to functional systems #Mitochondria #IronMetabolism The mass of the mitochondrial proteome is significantly greater in pDC versus cDC1 and cDC2 🧵8/12

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David Finlay @davidfinlaytcd.bsky.social · 22/05/2026

🧬 New in @eurjimmunol.bsky.social pDCs run a distinct iron programme: high TFRC, continuous iron flux, and targeted use in mitochondrial pathways, without increased iron storage. ➡️ However, lack of iron doesn’t limit IFN-I #paradox 🤯 🤷🏻‍♂️ #Immunology #Immunometabolism #pDC #TypeIIFN 🧵1/12

pDC have lots of surface transferrin receptor and continuous transferrin-iron import. In contrast, cDC keep lots of their transferrin receptor intracellularly, ready to export to the membrane if needed. Despite constant, uptake pDC to not accumulate iron but express the iron exporter ferroportin. Iron is not required for pDC's best described function, the production of type one interferon.

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David Finlay @davidfinlaytcd.bsky.social · 06/11/2025

Preserving intracellular glutamate supports CD8 T cell anti tumour function. Research from the Rathmell lab point to Glutamine synthetase a potential target for cancer immunotherapy academic.oup.com/jimmunol/art...

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David Finlay @davidfinlaytcd.bsky.social · 22/07/2025

10,000 people marched in Dublin this weekend. Ireland stands against genocide. Free Palestine.

10,000 people marched this weekend in Dublin, Ireland

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David Finlay @davidfinlaytcd.bsky.social · 05/01/2025

Metabolic #plasticity to Slc1a5 loss involving upregulation of macropinocytosis. Important also for #immune cells to support glutamine requirements? #immunometabolism “Macropinocytosis mediates resistance to loss of glutamine transport in TNBC” www.embopress.org/doi/full/10....

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David Finlay @davidfinlaytcd.bsky.social · 10/12/2024

And from National University of Ireland Maynooth (NUIM), Eimear Ryan from @andyhogan82.bsky.social lab will present her work at the December @immunometforum.bsky.social on #MAITcell #metabolism. #immmunosky #immunoology #immunometabolism

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David Finlay @davidfinlaytcd.bsky.social · 10/12/2024

The December @immunometforum.bsky.social will take place this Friday with three great early career researcher presenting: 🧵1/4 #immmunosky #immunoology #immunometabolism

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David Finlay @davidfinlaytcd.bsky.social · 30/11/2024

New review article written by Cristhiane Favero de Aguiar and Carrie Corkish from my lab. They did a great job. www.nature.com/articles/s41... #SingleCell #Immunometabolism #ImmunoSky Approaches to investigate tissue-resident innate lymphocytes metabolism at the single-cell level

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David Finlay @davidfinlaytcd.bsky.social · 23/11/2024

Long chain acyl-carnitine Palmitoylcarnitine is elevated in diseases including T2D and obesity, and this study suggests it can cause mitochondrial dysfunction in immune cells. Palmitoylcarnitine impairs immunity in decompensated cirrhosis - JHEP Reports www.jhep-reports.eu/article/S258...

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David Finlay @davidfinlaytcd.bsky.social · 23/11/2024

Interesting, a fluorescent biosensors to illuminate arginine metabolism in cells, mice, and clinical samples. #Arginine #biosensor Lighting up arginine metabolism reveals its functional diversity in physiology and pathology: Cell Metabolism www.cell.com/cell-metabol...

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David Finlay @davidfinlaytcd.bsky.social · 20/11/2024

Another lactate dependent immunosuppressant mechanism, here in Glioblastoma #GBM #Lactate #CD47 #HistoneLactylation JCI - Lactate reprograms glioblastoma immunity through CBX3-regulated histone lactylation www.jci.org/articles/vie...

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David Finlay @davidfinlaytcd.bsky.social · 17/11/2024

Interesting link between high glucose in T2D patients and impaired T cells responses towards virus. #LipidPeroxidation #TcellSignalling #T2D Hyperglycemia-triggered lipid peroxidation destabilizes STAT4 and impairs anti-viral Th1 responses in type 2 diabetes www.sciencedirect.com/science/arti...

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