Diurnal hepatic metabolism is coordinated by the circadian clock and feeding rhythms, notably through post-translational modifications. ACSF3 links feeding schedules to rhythmic lysine-malonylation and metabolic homeostasis. Le Questel et al. report that ACSF3 controls glucose, lipid metabolism and autophagy rhythmicity, positioning ACSF3 as a central regulator of diurnal liver homeostasis.

When we think about metabolism, we usually ask, "What did I eat? How much sugar, fat or protein was in the meal?" But through our research, we have become interested in another question: "When did I eat it?" This matters because metabolism does not work at the same pace throughout the day.

Hepatic daily rhythms are coordinated by feeding and the molecular circadian clock, ensuring metabolic homeostasis. Disrupted feeding schedules promot…

Hepatic glycogenolysis is essential for protein glycosylation and rhythmic secretion by the liver. Disruptions to hepatic glycogenolysis, caused by congenital diseases or physiological factors such as...

npj Metabolic Health and Disease - Potential bidirectional communication between the liver and the central circadian clock in MASLD

Curiosity-driven research is exactly what it sounds like: research driven by the goal of understanding nature without regard for application.

Here’s how your body might respond when you turn your clock back an hour on Saturday night.