iiinova — where your digital self keeps evolving

Daniel Drucker @danieljdrucker.bsky.social · 26/08/2026

Here the authors identify the glucagon-PKA-PDE2A-NCLX signaling axis as a key metabolic rheostat integrating mitochondrial calcium dynamics with lipid homeostasis, providing a promising therapeutic target for MASLD @MolMetab www.sciencedirect.com/science/arti...

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Daniel Drucker @danieljdrucker.bsky.social · 25/07/2026

Challenged by the complexity of explaining GLP-1 medicines to friends and family? Gustav Hållén the talented producer of Zero Order has figured it out. Have a listen www.youtube.com/watch?v=VCIW...

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Daniel Drucker @danieljdrucker.bsky.social · 02/05/2026

New experimental insights into vagal mechanisms triggered by allulose to improve insulin sensitivity diabetesjournals.org/diabetes/art...

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Daniel Drucker @danieljdrucker.bsky.social · 22/04/2026

A potentially targetable pathogenic signature of EV-associated miRNAs capable of stratifying type 1 diabetes risk #islets @diabetologiajnl.bsky.social link.springer.com/article/10.1...

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Daniel Drucker @danieljdrucker.bsky.social · 14/04/2026

Although #weightloss is highly beneficial to reduce fat and inflammation in the liver, posthoc analysis of the ESSENCE trial reveals substantial weight loss-independent benefits of semaglutide #MASH How does this happen?

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Daniel Drucker @danieljdrucker.bsky.social · 14/04/2026

A new review on GIP from the experts. While the narrative clearly highlights GIPR agonism suppresses food intake, the Figure implies GIP increases food intake diabetesjournals.org/care/article...

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Daniel Drucker @danieljdrucker.bsky.social · 14/04/2026

Towards actionable ascertainment of #diabetes risk in cluster subtypes with #weightloss diabetesjournals.org/diabetes/art...

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Daniel Drucker @danieljdrucker.bsky.social · 11/04/2026

Happy birthday to Professor Emeritus Bernie Zinman, newly elected member of the @CdnMedHallFame @uoftmedicine @SinaiHealth www.cdnmedhall.ca/bernard-zinm... #diabetes @DiabetesCanada

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Daniel Drucker @danieljdrucker.bsky.social · 11/04/2026

As the therapeutic benefits of GLP-1 medicines expand, the interest in the weight loss independent contributions continues to unfold linkinghub.elsevier.com/retrieve/pii...

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Daniel Drucker @danieljdrucker.bsky.social · 04/04/2026

Here the authors propose repurposing readily accessible DPP-4 inhibitors to enhance anti-tumor CD8+ T cell responses #cancer www.biorxiv.org/content/10.6...

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Daniel Drucker @danieljdrucker.bsky.social · 04/04/2026

Associations in humans suggest that Hyperglucagonemia in the face of higher hepatic lipid content in early #T2D is not due to differences in insulin sensitivity or glucagonotropic metabolites but could suggest hepatic glucagon resistance diabetesjournals.org/care/article...

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Daniel Drucker @danieljdrucker.bsky.social · 02/04/2026

Increasing options for patients with a choice of new oral GLP-1 medicines is a welcome development. The competitive messaging is well underway for oral semaglutide vs. Orforglipron #weightloss #tolerability www.novonordisk.com/news-and-med...

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Daniel Drucker @danieljdrucker.bsky.social · 31/03/2026

The 2026 Canada GairdnerAwards Laureates from Cryo-EM to amyloid aggregation,systems proteomics, cholera control, bacterial immunity, BP control after spinalinjury #Science www.newswire.ca/news-release...

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Daniel Drucker @danieljdrucker.bsky.social · 30/03/2026

A continuous intravenous LEAP2 infusion for 5 hrs reduces glycemia and food intake in men with #obesity diabetesjournals.org/diabetes/art...

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Daniel Drucker @danieljdrucker.bsky.social · 30/03/2026

While waiting for FOCUS, analysis of a matched real world TriNetX cohort of 350,536 patients with #T2D and #CVD followed for up to 5 years revealed reduced rates of legal blindness pubmed.ncbi.nlm.nih.gov/41907810/

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Daniel Drucker @danieljdrucker.bsky.social · 28/03/2026

In the ATLAS data semaglutide-induced downregulation of PTPRU & genetically reduced PTPRU function promote greater #weightloss This gene has no previous known functional relationship to weight loss or related metabolic functions. www.cell.com/cell/fulltex... #genetics @cp-cell.bsky.social

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Daniel Drucker @danieljdrucker.bsky.social · 27/03/2026

An open-source web atlas of all orphan oGPCR expression in the human brain to serve as a neuro-resource for the broader scientific community. www.biorxiv.org/content/10.6...

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Daniel Drucker @danieljdrucker.bsky.social · 25/03/2026

The primary cilium functions as a non-redundant signaling compartment essential for GLP-1R action in islet beta cells www.sciencedirect.com/science/arti...

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Daniel Drucker @danieljdrucker.bsky.social · 25/03/2026

Preclinical and clinical exploration of dual GLP-1R-GLP-2R agonism for metabolic disease via PG-102 www.nature.com/articles/s41...

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Daniel Drucker @danieljdrucker.bsky.social · 22/03/2026

Insights from derivation of human IPS #stemcell derived islet-like or off-target enterochromaffin (EC)-like cells in the pancreas #diabetes www.nature.com/articles/s41...

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Daniel Drucker @danieljdrucker.bsky.social · 21/03/2026

A. muciniphila VHAKM enhances GLP-1 secretion in a strain- and form-dependent manner, with live cells showing superior efficacy www.biorxiv.org/content/10.6...

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Daniel Drucker @danieljdrucker.bsky.social · 19/03/2026

P3 40 week data for Retatrutide in people with #T2D #diabetes investor.lilly.com/news-release... #weightloss

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Daniel Drucker @danieljdrucker.bsky.social · 17/03/2026

An update on new clinical trial data for setmelanotide in rare genetic forms of #obesity ir.rhythmtx.com/news-release...

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Daniel Drucker @danieljdrucker.bsky.social · 17/03/2026

Here the authors propose that treatment of adipocytes with BMPs results in an energy expending phenotype without transdifferentiation into beige adipocytes, providing a new approach to treat #obesity related metabolic disease. insight.jci.org/articles/vie...

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Daniel Drucker @danieljdrucker.bsky.social · 16/03/2026

Postmenopausal #osteoporosis Should some individuals with rapid #weightloss on GLP-1 medicines #obesity consider anti-resorptive therapy on top of lifestyle management? How to prospectively identify candidates? academic.oup.com/edrv/advance...

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Daniel Drucker @danieljdrucker.bsky.social · 15/03/2026

Blautia wexlerae affects host metabolic control in part through #mcrobiota metabolites stimulating GLP-1 secretion www.biorxiv.org/content/10.6...

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Daniel Drucker @danieljdrucker.bsky.social · 14/03/2026

Under severe inflammatory conditions such as LPS administration, pancreatic production of GLP-1 functions in an immunological rather than a metabolic role to directly regulate local macrophage accumulation www.mdpi.com/2073-4409/15... mdpi-res.com/cells/cells-...

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Daniel Drucker @danieljdrucker.bsky.social · 12/03/2026

Safety first-new analyses of B12-compounded Tirzepatide investor.lilly.com/node/53991/pdf

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Daniel Drucker @danieljdrucker.bsky.social · 11/03/2026

@AmDiabetesAssn names superb scientists recipients of the 2026 Banting Medal, Prof Takashi Kadowaki, and the Outstanding Scientific Achievement Award, Prof Timo Müller www.prnewswire.com/news-release...

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Daniel Drucker @danieljdrucker.bsky.social · 08/03/2026

Studies in Drosophila reveal that the Akh (glucagon-mimetic) signaling pathway provides new understanding of the regulatory mechanisms between metabolic disease and cardiac arrhythmia. elifesciences.org/articles/94512 iiif.elifesciences.org/lax:94512%2F...

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Daniel Drucker @danieljdrucker.bsky.social · 06/03/2026

In normal healthy human male subjects, acute GIP infusion does not modulate splanchnic blood flow academic.oup.com/jcem/advance...

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Daniel Drucker @danieljdrucker.bsky.social · 04/03/2026

New from Megan Capozzi @UW Postprandial glycogen repletion and the surprising role of glucagon insight.jci.org/articles/vie... @insight.jci.org

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Daniel Drucker @danieljdrucker.bsky.social · 03/03/2026

GLP-1 medicines have multiple direct and indirect effects that modify cardiovascular risk. Here Kyle Medak @SinaiHealth and colleagues identify an important role for the VSM GLP-1R in the reduction of blood pressure #hypertension @JCI_insight @uoftmedicine insight.jci.org/articles/vie...

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Daniel Drucker @danieljdrucker.bsky.social · 02/03/2026

The BELIEVE study, the efficacy and safety of intravenous bimagrumab and open-label subcutaneous semaglutide, alone or in combination, in adults with #obesity www.nature.com/articles/s41...

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Daniel Drucker @danieljdrucker.bsky.social · 28/02/2026

Is persistence improving with new #weightloss medicines? www.jmcp.org/doi/10.18553...

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Daniel Drucker @danieljdrucker.bsky.social · 27/02/2026

The important role of IL2RA in immune tolerance and β-cell protection highlighted by early onset type 1 #diabetes diabetesjournals.org/diabetes/art... ada.silverchair-cdn.com/ada/content_...

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Daniel Drucker @danieljdrucker.bsky.social · 27/02/2026

Studies in mice define endocrine-exocrine beta cell-derived CCK signaling as a bona fide driver of #obesity associated PDAC development and uncover avenues to target the endocrine pancreas to subvert exocrine tumorigenesis. #pancreaticcancer www.nature.com/articles/s41...

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Daniel Drucker @danieljdrucker.bsky.social · 27/02/2026

SEL1L-HRD1 endoplasmic reticulum (ER)-associated degradation (ERAD) is a regulator of PC2 biology and an essential mechanism for maintaining α cell function and glucagon biosynthesis www.nature.com/articles/s41...

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Daniel Drucker @danieljdrucker.bsky.social · 26/02/2026

ACHIEVE-3 Oral semaglutide vs. Orforglipron #T2D www.thelancet.com/journals/lan...

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Daniel Drucker @danieljdrucker.bsky.social · 26/02/2026

ACHIEVE-3 Orforglipron (12 & 36mg) vs. Oral semaglutide at doses (7 & 14mg) approved for #T2D #diabetes investor.lilly.com/news-release...

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Daniel Drucker @danieljdrucker.bsky.social · 24/02/2026

Studies of mitochondrial activity in mice #obesity reveal that microRNA let-7 in sperm reprograms offspring metabolism by modulating mitochondrial function during early development www.nature.com/articles/s41...

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Daniel Drucker @danieljdrucker.bsky.social · 24/02/2026

New from Klaus Kaestner Foxl1 orchestrates key events during the epithelial transition of the fetal mammalian gut via signaling in telocyte progenitors www.nature.com/articles/s41...

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Daniel Drucker @danieljdrucker.bsky.social · 24/02/2026

P2 #weightloss data #obesity for an emerging triple G agonist in China, mean baseline weight 92.2 kg link.springer.com/article/10.1...

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Daniel Drucker @danieljdrucker.bsky.social · 21/02/2026

IL-22 identified as an important regulator of intestinal GLP-1 production and glucose homeostasis during diet-induced #obesity in mice www.nature.com/articles/s41...

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Daniel Drucker @danieljdrucker.bsky.social · 18/02/2026

First Psoriatic arthritis now #Psoriasis together with ixekizumab investor.lilly.com/news-release...

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Daniel Drucker @danieljdrucker.bsky.social · 16/02/2026

The as yet unfulfilled promise of GLP-1 medicines and neurodegenerative disorders @jclinicalinvest www.jci.org/articles/vie... dm5migu4zj3pb.cloudfront.net/manuscripts/...

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Daniel Drucker @danieljdrucker.bsky.social · 15/02/2026

GLP-1 (glucagon-like peptide 1) protects the mouse heart after ischaemia by activating ATP-sensitive K+ channels on pericytes that constrict coronary capillaries www.nature.com/articles/s41...

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Daniel Drucker @danieljdrucker.bsky.social · 12/02/2026

Broadening the intersection of GIPR signaling with anorectic and aversive actions of PYY in mice @MolMetab www.sciencedirect.com/science/arti...

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Daniel Drucker @danieljdrucker.bsky.social · 10/02/2026

AI based analysis of human pancreatic histology provides a foundation for future research into relevant diagnostic and therapeutic targets, refining several hypotheses regarding tissue alterations associated with #T2D www.nature.com/articles/s41...

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Daniel Drucker @danieljdrucker.bsky.social · 09/02/2026

Observational cohort data from All of Us suggest that prior Rx for GLP-1RAs may reduce alcohol consumption by decreasing use frequency. www.medrxiv.org/content/10.6...

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