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Dan Grabarczyk

@dangrabarczyk.bsky.social
545 followers 875 following 7 posts

Structural biologist - currently ubiquitin ligases, previously DNA replication and bacterial metabolism Research Associate - Clausen Lab, IMP Vienna

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Dan Grabarczyk @dangrabarczyk.bsky.social · 28/08/2025
Glad to share the final version of our story about the UBR4 complex, an E4 ligase protein quality control hub @science.org. Now with more cryo-EM structures and a deeper dive into substrate recognition, especially escaped mitochondrial proteins @clausenlab.bsky.social www.science.org/doi/10.1126/...
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Dan Grabarczyk @dangrabarczyk.bsky.social · 21/12/2024
Happy to share our UBR4 structures. Check out the preprint to see how this giant E4 ligase complex selects substrates for ubiquitin chain extension. We also look at conservation and adaptations across humans, nematodes and plants. www.biorxiv.org/content/10.1... @clausenlab.bsky.social
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