Sign in

Dan Depledge

@dandepledge.bsky.social
716 followers 402 following 41 posts

Associate Professor @ Hannover Medical School. Virology, RNA biology, and Computational Biology. Global villager. Lab website: depledgelab.github.io

PostsRepliesMedia
Dan Depledge @dandepledge.bsky.social · 12/04/2026
First time in Belfast and very much looking forward to the UK Microsoc meeting. First time in a long time... #Microbio26
060
Dan Depledge @dandepledge.bsky.social · 14/03/2025
Our latest preprint is online! In which we take a left turn and dive head first into the biology of the RNA polymerase III transcriptome and epitranscriptome Do you want to know more? A small thread follows👇 www.biorxiv.org/content/10.1...
biorxiv.org
Defining expansions and perturbations to the RNA polymerase III transcriptome and epitranscriptome by modified direct RNA nanopore sequencing
RNA polymerase III (Pol III) transcribes cytosolic transfer RNAs (tRNAs) and other non-coding RNAs (ncRNAs) essential to cellular function. However, many aspects of Pol III transcription and processin...
192
Reposted by Dan Depledge
Milo B. Fasken, Ph.D. @milofasken.bsky.social · 11/03/2025
#GeneExpression #Review #mRNA #RNA #RNAProcessing wires.onlinelibrary.wiley.com/doi/full/10....
wires.onlinelibrary.wiley.com
Post‐Transcriptional Regulation of Gene Expression and the Intricate Life of Eukaryotic mRNAs
The central dogma of biology relies on numerous regulatory events to define the expression profile of any given cell. Created in https://BioRender.com.
062
Dan Depledge @dandepledge.bsky.social · 07/03/2025
A teaser for our new preprint that will be available soon!!! Pol III, RNA modifications, tRNAs, viruses, and of course, nanopores
040
Reposted by Dan Depledge
Exzellenzcluster RESIST @resist-cluster.bsky.social · 12/02/2025
The master’s program in #biomedical_data_science, which was developed as part of RESIST, has now graduated for the second time: 18 students from the first two years successfully completed their studies. www.resist-cluster.de/en/festive-s... 🎉 @dandepledge.bsky.social @bosse-lab.bsky.social
resist-cluster.de
Festive setting
Festive setting for the presentation of certificates to students of biomedical data science: The master's program in biomedical data science, which was developed as part of the RESIST project, has now...
041
Reposted by Dan Depledge
Viejo-Borbolla Lab @viejoborbolla.bsky.social · 20/02/2025
Happy to share our publication in #PlosPathogens investigating repression of varicella zoster virus in neuron-like cells: journals.plos.org/plospathogen... Thanks to @dandepledge.bsky.social and other colleagues for their contribution!
journals.plos.org
Repression of varicella zoster virus gene expression during quiescent infection in the absence of detectable histone deposition
Author summary Varicella zoster virus (VZV) establishes latent infection exclusively in human neurons. This phase of infection is characterized by restricted viral gene expression, lack of detectable ...
3103
Dan Depledge @dandepledge.bsky.social · 06/02/2025
Congratulations to all the graduates of the MHH Biomedical Data Science Masters programme! The graduation ceremony today was a great success and we really appreciated @bosse-lab.bsky.social giving a great lecture!
140
Dan Depledge @dandepledge.bsky.social · 29/01/2025
Love it when you read a review that completely unlocks a new field of biology that you are working in.
000
Dan Depledge @dandepledge.bsky.social · 08/01/2025
me: i need help with some visa questions local admin directly responsible for such matters: no me: ??? admin: you need to sort this out yourself admin: also, you are not properly registered as a foreigner in our system, this is clearly your fault and definitely not ours... me: ???
120
Dan Depledge @dandepledge.bsky.social · 07/01/2025
First day back at work and so far I have a broken computer, a VPN that cannot maintain it's connection and half my lab has been lost to a time management course that, no kidding, is 8 hours long!!!
media.tenor.com
today has been cancelled go back to bed
ALT: today has been cancelled go back to bed
040
Dan Depledge @dandepledge.bsky.social · 03/01/2025
Thank goodness for section 81 paragraph 4 of the German residence act!
010
Dan Depledge @dandepledge.bsky.social · 02/01/2025
2025 goals Get off facebook - done Get off twitter/x - done Navigate German bureaucracy to obtain a settlement permit so that I am not forced to leave the EU in June - pending Brexit, truly the gift that keeps on giving...
010
Dan Depledge @dandepledge.bsky.social · 02/12/2024
Making progress...
030
Dan Depledge @dandepledge.bsky.social · 17/11/2024
So good to see membership of this platform increasing so fast. So much great science content already :)
040
Dan Depledge @dandepledge.bsky.social · 11/11/2024
Nice to see the communities of RNA biologists and herpesvirologists are growing on here. Now we just need more nanopore people!
030
Dan Depledge @dandepledge.bsky.social · 13/11/2023
Remind me again why I left the wonderful sun and blue skies of NYC...
It always rains in Hannover...
220
Reposted by Dan Depledge
Marco Galardini @mgalactus.bsky.social · 06/11/2023
The HZI will hire up to twenty (20!) tenure-track research groups under the broad topic of "Microbial Stargazing" (🦠🌌). The first round of 4 positions is now open; the call closes on the 10th of December. Please share! www.helmholtz-hzi.de/en/career/jo...
01120
Dan Depledge @dandepledge.bsky.social · 02/11/2023
Trying to write computational/sequencing focused paper that explores the biology of three very different viruses is proving a bigger challenge than I had anticipated...
130
Dan Depledge @dandepledge.bsky.social · 17/10/2023
Great to see this online and very happy to have contributed to this study led by Hannah Burgess (NYU & University of Surrey) and Ian Mohr (NYU)!!! www.embopress.org/doi/full/10.... #is_there_anything_nanopores_cant_do
embopress.org
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
010
Dan Depledge @dandepledge.bsky.social · 14/10/2023
Very much looking forward to reading this, especially with coronaviruses in mind as a number of studies (inc one I contributed to) have reported varying levels of m6A to be present (validated by orthogonal methods) which remains counterintuitive in many ways...
110
Reposted by Dan Depledge
Ed Emmott @edemmott.bsky.social · 27/09/2023
The lab has just been awarded an 8-year grant to study coronavirus replication! 🍾🎉 Job ads will appear around end October but we are particularly looking for PDRAs with coronavirus reverse genetics experience or CL3 coronavirus-host interactions. ~Mar 2024 start.
64414
Dan Depledge @dandepledge.bsky.social · 01/10/2023
Still recovering from the mini herpesvirus conference (+ assorted bugs the kids brought home from daycare) but still happily reflecting on what an interesting and fun day it was!!! Lots of thanks to go around but I would particularly highlight our two plenary speakers and our army of volunteers!
260
Dan Depledge @dandepledge.bsky.social · 29/09/2023
The 16th mini herpesvirus workshop is in full swing! Over 100 participants from 33 institutions across six countries. An excellent plenary talk from Hannah Burgess (University of Surrey) on the role of the CCR4-NOT complex in HCMV infections (that has just been accepted for publication)!
031
Dan Depledge @dandepledge.bsky.social · 27/09/2023
Easily one of my favorite books ever!
000
Dan Depledge @dandepledge.bsky.social · 27/09/2023
Two days until the 16th mini herpesvirus workshop!
000
Reposted by Dan Depledge
Nandan Gokhale @nandangokhale.bsky.social · 26/09/2023
m7GpppNm - VERY EXCITED to share my postdoctoral work in @ramlabuw.bsky.social’s lab, now @bioRxiv. We find that cellular RNA interacts with MAVS, the adaptor protein of the RIG-I-like receptor pathway, to promote antiviral signaling. A 🧵:
14113
Reposted by Dan Depledge
Luis M @luismschang.bsky.social · 26/09/2023
Hold your excitement.... for now 🙃
011
Dan Depledge @dandepledge.bsky.social · 23/09/2023
This is insane... and explains a lot! community.nanoporetech.com/posts/flow-c...
010
Reposted by Dan Depledge
Moriah Szpara @szparalab.bsky.social · 22/09/2023
In honor of all the new peeps rebuilding science-social over here (thank goodness!), here's a super-cool new preprint from my old labmate Matt Taylor's group -- on single-cell analyses of HSV1, in neurons cultured in little droplets. Check it out! Matt's not yet on bluesky, but we'll get him here!
biorxiv.org
Single-cell Herpes Simplex Virus type-1 infection of neurons using drop-based microfluidics reveals ...
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
2239
Dan Depledge @dandepledge.bsky.social · 21/09/2023
Here I am now, entertain me!
040