Reposted by Branko RihtmanFreya Harrison @friendlymicrobe.bsky.social · 25/09/2026What‘s the biggest, most exciting or nagging unanswered question in biology? What do you really, really wish we knew the answer to? I’m crowdsourcing responses to these Qs for my welcome talk to new Biology undergrads next week. I’d love to know your thoughts - thank you in advance! 112
Branko Rihtman @cyanoney.bsky.social · 25/09/2026Jess is a great scientist and a wonderful mentor, highly recommended! 020
Reposted by Branko RihtmanEllie Jameson @elliejameson.bsky.social · 22/09/2026MScRes bursary of £2000 available at Bangor University to study Bacteriophages as natural biocontrols for plant pathogens. Deadline is 19th October. Please contact me for more details #PhageSky #MicroSky 049
Branko Rihtman @cyanoney.bsky.social · 17/09/2026What a great story and an excellent experimental model system. I'm sure there will be many exciting discoveries arising from this work! Congrats!! 110
Reposted by Branko RihtmanMark van Raaij @markvanraaij.eurosky.social · 26/08/2026Please look at our structure of the Salmonella bacteriophage epsilon15 tailspike. We show activity for the “usual” LPS hydrolysis site and an esterase site by NMR and structures with LPS. It reveals multiple O-antigen binding sites and a protruding esterase domain www.biorxiv.org/content/10.6...biorxiv.orgThe structure of the Salmonella phage epsilon15 tailspike reveals multiple O-antigen binding sites and a protruding esterase domainMany bacteriophages use tailspikes to degrade host bacterial polysaccharides, facilitating access to the outer membrane. The homotrimeric tailspikes of the Salmonella phage epsilon15 feature a slender... 063
Branko Rihtman @cyanoney.bsky.social · 24/08/2026This was first done more than 20 years ago, among others by Prof. Shimshon Belkin at HUJI. Reviewed here: doi.org/10.1016/S136...doi.orgRedirecting 020
Branko Rihtman @cyanoney.bsky.social · 19/08/2026I don't think this research measures the mental reassurance component of having the Bunsen burner on as you work with open plates. 011
Branko Rihtman @cyanoney.bsky.social · 31/07/2026We should limit paper submission to 3 journals. If 3 separate journals (with different reviewers) reject the same paper, it shouldn't be published, until the authors show that they've addressed all the criticisms. 000
Branko Rihtman @cyanoney.bsky.social · 16/07/2026I read the name of the movie and now all the neighbourhood cats are in front of my house 020
Reposted by Branko RihtmanOsterman Ilya @ostermanilya.bsky.social · 13/07/2026🚨 We're hiring! My new lab at EMBL Hamburg is looking for a Research Technician. I'm looking for someone excited by phages, metabolism, enzymes, structural biology and bacterial immunity—if you know the right person, please share this post!🧵⬇️ Apply here: embl.wd103.myworkdayjobs.com/en-US/EMBL/j...embl.wd103.myworkdayjobs.comResearch Technician (Osterman Group – Metabolism-driven immunity)EMBL Hamburg / CSSB The European Molecular Biology Laboratory (EMBL) is Europe’s flagship life sciences organization, with more than 110 independent research groups across Heidelberg, Hamburg, Grenobl... 32940
Branko Rihtman @cyanoney.bsky.social · 10/07/2026This is such a fantastic episode. Made even more fantastic by the singing. 000
Branko Rihtman @cyanoney.bsky.social · 10/07/2026I will never understand why people don't want to test for Covid anymore... It is so easy and readily available. In 15 minutes you know whether you have it or not. The COVID-Flu testing combo costs £4. Why wouldn't you want to know whether you should stay away from people for a few days or not? 010
Reposted by Branko RihtmanSorek Lab @soreklab.bsky.social · 09/07/2026Our paper out in Science today: The Metis defense system senses molecular byproducts released when a phage degrades the bacterial genome, and then prevents replication of the phage in the infected cell Congratulations @ostermanilya.bsky.social and co-authors!science.orgBacteria sense virus-induced genome degradation via methylated mononucleotidesPhages often degrade the genome of their bacterial host to individual nucleotides. Here we describe Metis, a bacterial defense system that directly senses phage-mediated host genome degradation. Metis... 410353
Branko Rihtman @cyanoney.bsky.social · 30/06/2026I have yet to find a phage genome extraction kit that produces a yield comparable to the good old phenol chloroform extraction. Latest comparison: extraction from 20ml of lysate each, 340ng/μl with phenol, 81ng/μl with a commercial kit, in the same elution volume. 000
Branko Rihtman @cyanoney.bsky.social · 11/05/2026New version of Inphared!!! With improved capabilities, such as defence and anti defence annotation in phage genomes, predicted lifestyle annotation, constantly expanding curated phage genome database and other improvements! Check out the preprint with all the numbers. 2153
Branko Rihtman @cyanoney.bsky.social · 30/04/2026It is comforting to know that in this world of social uncertainties, rising fascism, perpetual war, and global economic instability, Gibson cloning still works. 010
Branko Rihtman @cyanoney.bsky.social · 28/04/2026Very glad to see this out. A huge effort by a lot of people. Well done everyone!! www.microbiologyresearch.org/content/jour...microbiologyresearch.orgRolling out Plaque-2-seq: a single plaque sequencing approach enabling rapid, low-cost sequencing of phages directly from plaquesRapid, accurate and scalable sequencing of bacteriophage genomes is critical to advance phage therapy, build phage biobanks and understand phage genomic diversity. Current methods are based on sequenc... 063
Branko Rihtman @cyanoney.bsky.social · 20/04/2026It makes me so angry that we have to justify this technology to people with primary-school level reading skills at best. And those people somehow got to have their thumb on the kill switch of the research that enables this life-saving treatment. 020
Branko Rihtman @cyanoney.bsky.social · 17/04/2026A scientific misconduct on so many levels. Not the least by the journal which 1) doesn't ensure that the study that they published collected the data in a way that can be shared, and 2) refuses to publish the guidelines for reviewers to prevent this from happening again. Retract. 000
Branko Rihtman @cyanoney.bsky.social · 16/04/2026Wow wonderful work, many congratulations @emmajbanks.bsky.social !!! Looking forward to hearing more about this and your other work when you visit us at @warwicklifesci.bsky.social next month!!! 100
Reposted by Branko RihtmanFreya Harrison @friendlymicrobe.bsky.social · 15/04/2026Find out about how different host-mimicking environments alter P. aeruginosa biofilm from @kadeayomikun.bsky.social at poster 169 at #Microbio26 0105
Reposted by Branko RihtmanFreya Harrison @friendlymicrobe.bsky.social · 14/04/2026Cracking talk from @nreddy.bsky.social about her PhD work - designing polymers based on AMPs to kill troublesome biofilm bacteria, or to help antibiotics kill these bacteria #Microbio26 0163
Reposted by Branko RihtmanFreya Harrison @friendlymicrobe.bsky.social · 14/04/2026Come to #Microbio26 poster 192 to hear how @charisthompson.bsky.social is sensitising mycobacteria to beta-lactams by making them flip their wall-building strategy #MicroSky 0225
Branko Rihtman @cyanoney.bsky.social · 09/04/2026What a wonderful read. Definitely keeping this for future reference. 021
Branko Rihtman @cyanoney.bsky.social · 09/04/2026Wonderful opportunity with a great PI!! Highly recommended. 010
Branko Rihtman @cyanoney.bsky.social · 02/04/2026This does my head in. There is ZERO evidence that phoH in bacteriophages in general, and cyanophages in particular, has anything to do with P metabolism. The evidence for phoH role in bacterial P metabolism is not very strong either. There is no harm in being careful in your interpretations. 121
Branko Rihtman @cyanoney.bsky.social · 30/03/2026Judging by what I've heard from my colleagues, this movie should come with a trigger warning for this reason. "may upset scientists" 100
Branko Rihtman @cyanoney.bsky.social · 24/03/2026Why are the worst possible people making the most important decisions? 010
Branko Rihtman @cyanoney.bsky.social · 24/03/2026with proliferation of transposon knockout libraries for different bacterial species (like Keio collection), I'm afraid that the art of generating knockouts via transformation is slowly going to die away. 000
Reposted by Branko RihtmanFreya Harrison @friendlymicrobe.bsky.social · 19/03/2026#MicroSky people, have you ever grown a Staph aureus biofilm that forms a crispy or hard exterior crust (not in urine)? My MBio student Izabela has, and we are not finding much literature on this. 0612
Branko Rihtman @cyanoney.bsky.social · 27/02/2026This is a fantastic achievement for Reform and I wish them to get the second largest number of votes in every election they ever stand in 010
Reposted by Branko RihtmanFreya Harrison @friendlymicrobe.bsky.social · 18/02/2026During her PhD, Jenny found something unexpected: biofilm-deficient P. aeruginosa mutants were just as tolerant to antibiotics as the WT when grown in our cystic fibrosis lung model. But why? #MicroSky 1/n 23215
Branko Rihtman @cyanoney.bsky.social · 13/02/2026"Why do you care about US politics?" No reason. No reason at all. 032
Reposted by Branko RihtmanMicrobiology Society @microbiologysociety.org · 11/02/2026On International Day of Women and Girls in Science 🔬👩🔬 We’re launching the Women Microbiologists Network: a member-led networking and discussions event for women in microbiology by Dr. Enas Newire. Read the news story and join: 🔗 microb.io/4ax5M5I 11612
Branko Rihtman @cyanoney.bsky.social · 03/02/2026This is such a fascinating topic and brilliant work by @tosinorababa.bsky.social 010
Branko Rihtman @cyanoney.bsky.social · 02/02/2026Two questions which should be ask at the beginning of each project: 1. What's the question? 2. Which controls will you use? 120
Reposted by Branko RihtmanFreya Harrison @friendlymicrobe.bsky.social · 29/01/2026Why should microbiologists be interested in historical infection remedies, and how can we best investigate them for antimicrobial discovery? Thoroughly enjoyed co-writing this Microbiology Primer with @tosinorababa.bsky.social www.microbiologyresearch.org/content/jour... #MicroSky #Ancientbioticsmicrobiologyresearch.orgMicrobial Primer: Ancientbiotics – making modern antimicrobials from historical infection remediesThe modern antibiotic era began in the early twentieth century, but humans have long used materials from the natural world to attempt to treat the symptoms of infection. In this primer, we will discus... 22412
Reposted by Branko RihtmanSteven Robbins @stevenjrobbins.bsky.social · 28/01/2026Curious, what's the best-practice tool at this point for taxonomically classifying long reads from metagenomes from less well-characterised environments? My impression is that Kraken will give lots of false positives and mis-classify taxa not in its database. Please share around for visibility. 61810
Reposted by Branko RihtmanIan Lidbury @iandealidbury.bsky.social · 14/01/2026In case you missed it. For any microbial ecologists, we recently published our long-standing study on identifying the major genes/molecular markers for glycine betaine degradation in environmental bacteria www.pnas.org/doi/full/10....pnas.orgPNASProceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans... 172
Reposted by Branko RihtmanAlexia Hapeshi @alexiahapeshi.bsky.social · 17/12/2025Dear all, I am aware I have not been on the platform for a while but NanoSyrinx is hiring again so I thought I would share. If you are anyone you know is interested, take a look below: www.linkedin.com/jobs/view/43...linkedin.comNanoSyrinx hiring Bioinformatician - Structural Biology/Protein Design and Engineering in Coventry, England, United Kingdom | LinkedInPosted 10:01:39 AM. ABOUT THE COMPANY NanoSyrinx is an award-winning synthetic biology company focused on a novel…See this and similar jobs on LinkedIn. 001
Branko Rihtman @cyanoney.bsky.social · 16/12/2025Been using Prokka for years now, excellent annotating software. Looking forward to try Bakta 010
Branko Rihtman @cyanoney.bsky.social · 12/12/2025Interesting phys.org/news/2025-12...phys.orgFast-tracking a natural climate solution by compressing millennia of carbon capture into hoursWhat if it were possible to take a very slow geological process, one that takes thousands of years in nature, and speed it up so that it happens within hours, in order to slow the rate of global warmi... 010
Branko Rihtman @cyanoney.bsky.social · 11/12/2025Have I agreed to review a grant over Xmas? Of course I have 🤦 000
Reposted by Branko RihtmanEleanor M. Townsend @emtownsend.bsky.social · 11/12/2025Our pre-print on staff & students perspectives on EDI in Medicine is available now on Research Square www.researchsquare.com/article/rs-7... We looked at what students feel confident in learning, what the curriculum currently represents, and how to support staff to enhance EDI topics further.researchsquare.comEnhancing equality, diversity, and inclusion in the undergraduate medicine curriculum: staff and student perspectivesIntroductionIncorporating equality, diversity, and inclusion (EDI) themes into medical curricula is essential for preparing students to support a diverse patient population. This study evaluated the r... 001
Reposted by Branko RihtmanSéamus Holden 🔬🦠🧫 @seamusholden.bsky.social · 11/12/2025@simonecoppola.bsky.social has made micromorph, the first native Python application and library for measuring bacterial morphology. It runs interactively in napari or can be easily integrated into automated Python scripts. It integrates deep learning cell segmentation and is easily extended 🔬🦠🧫 2106
Reposted by Branko RihtmanEvelien Adriaenssens @evelienadri.bsky.social · 11/12/2025I'm proud to share the latest methods work from my group. Led by @revathykri.bsky.social we wrote a book chapter on how we process and analyse viromes. Thanks to co-authors @rikhaagmans.bsky.social @ryancook94.bsky.social & Alise Ponsero link.springer.com/protocol/10....link.springer.comVirome AnalysisViruses are omnipresent and the most abundant biological entities on the planet. They play a critical role in shaping the ecology and evolution of all life forms. This chapter provides methods to perf... 12115