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Benjamin Brigant, PhD

@crisprandbeyond.bsky.social
400 followers 54 following 72 posts

Researcher 🔬 | CRISPR | Unraveling the link between inflammation and pathologies, Focus on Ehlers-Danlos syndrome and osteoarthritis PhD in France, Post doc in Norway and Canada

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Reposted by Benjamin Brigant, PhD
The Brigant Lab @brigantlab.bsky.social · 06/08/2026
Blueprints of life! 🧬 Let's see DNA and RNA. A quick refresher on the molecules that drive our research. Next up: the fascinating world of RNA!🔬 #AcademicSky #ScienceSky#InsideBrigantLab #RNA #DNA
DNA and RNA are two essential molecules that carry and use genetic information, but they have different roles.

**DNA** is the cell's long-term blueprint, storing the genetic instructions needed to build and maintain bodies functions.

 **RNA** acts as the messenger, carrying and translating those instructions so cells can produce the proteins they need.
#AcademicSky #ScienceSky#InsideBrigantLab #RNA #DNA
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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · 24/07/2026
Very inspiring three days at the training school on HDR and AAV delivery — great sessions, hands-on insights, and fantastic discussions with fellow researchers. Huge thanks to the organizers for putting together such a well-run event!
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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · 17/07/2026
Happy to share our new publication!
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Reposted by Benjamin Brigant, PhD
The Brigant Lab @brigantlab.bsky.social · 24/06/2026
Kicking off the Training School on homology-directed repair & AAV delivery technologies at the Kavli Institute for Systems Neuroscience in Trondheim, Norway 🇳🇴 (June 24-26). @kavlintnu.bsky.social
Kicking off the Training School on homology-directed repair & AAV delivery technologies at  the Kavli Institute for Systems Neuroscience in Trondheim, Norway 🇳🇴 (June 24-26).  
@kavlintnu.bsky.social
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Reposted by Benjamin Brigant, PhD
The Brigant Lab @brigantlab.bsky.social · 08/05/2026
Excellent lecture by Prof. Magnar Bjørås at NTNU. A strong reminder that meaningful collaboration with patient communities is the anchor for deep research and impactful innovation. Here: childhood dementia and rare genetic disorders. #ScienceSky #MedicalResearch #NTNU #BrigantLab
Excellent lecture by Prof. Magnar Bjørås at NTNU. 
A strong reminder that meaningful collaboration with patient communities is the anchor for deep research and impactful innovation.
Here: childhood dementia and rare genetic disorders.

#ScienceSky #MedicalResearch #NTNU #BrigantLab
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Reposted by Benjamin Brigant, PhD
The Brigant Lab @brigantlab.bsky.social · 05/05/2026
A portal to the invisible A microscope is more than a tool—it’s a way to connect what we see to what actually happens at the cellular level. This is where questions start to become answers. Where we move from what is happening to how it unfolds. #InsideBrigantLab #Microscopy #BiomedicalResearch
A portal to the invisible

A microscope is more than a tool—it’s a way to connect what we see to what actually happens at the cellular level.

This is where questions start to become answers.
Where we move from what is happening to how it unfolds.

#InsideBrigantLab #Microscopy #SciComm #BiomedicalResearch
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Reposted by Benjamin Brigant, PhD
The Brigant Lab @brigantlab.bsky.social · 01/05/2026
🌟 May is EDS & HSD Awareness Month! 🦓 With @ehlersdanlos.bsky.social, we’re joining the global community to raise our voices for millions affected by Ehlers-Danlos Syndromes & Hypermobility Spectrum Disorders. Let’s make the invisible visible. 💪✨ #EDSAwarenessMonth #HSD #ZebraStrong #BrigantLab
En caption ce message (seulement en anglais):
🌟 May is EDS & HSD Awareness Month! 🌟

Today it’s May! That means, it's Ehlers-Danlos Syndromes (EDS) and Hypermobility Spectrum Disorders (HSD) Awareness Month! 🦓
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🌐 Every May, the EDS&HSD global community unites to raise awareness, share experiences, and drive progress for millions affected by EDS and HSD.⁠
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Let’s come together to make the invisible visible. 💪✨
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💡 What can you do?
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✅ Learn about EDS & HSD.
✅ Share information and amplify awareness online.
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No matter where you are in the world, you can take part, raise your voice, and support this incredible community.🧡✨
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Together, we can create real change. 🌟🦓💙 
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#ehlersdanlossyndromes #Zebrastrong #EDSandHSDawarenessmonth #EDSCommunity  #BrigantLab
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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · 13/06/2025
It was such a great visit ! Always happy to learn and share with colleagues and patients. I can't wait for the next edition!
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Reposted by Benjamin Brigant, PhD
The Brigant Lab @brigantlab.bsky.social · 11/06/2025
Hello from EULAR 2025! 🏛️✨ Ready to explore, connect, and learn in Barcelona. 🌍🔬 #EULAR2025 #BrigantLab #ScienceInBarcelona #osteoarthritis #MedSky #AcademicSky
Hello from EULAR 2025! 🏛️✨ Ready to explore, connect, and learn in Barcelona. 🌍🔬
#EULAR2025 #BrigantLab #ScienceInBarcelona #osteoarthritis #MedSky #AcademicSky
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Reposted by Benjamin Brigant, PhD
The Brigant Lab @brigantlab.bsky.social · 17/05/2025
Gratulerer med dagen for 17 mai ! 🇳🇴🎊✨
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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · 13/05/2025
Always amazed by the cells under a microscope 😍
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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · 06/05/2025
Lots of exciting projects in our lab !
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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · 02/05/2025
First official publication after the start of the brigant lab ! The first of a long series! Thank you to all the authors and friends for this work.
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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · 25/04/2025
Go to like the page if you want to follow our adventure !
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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · 04/04/2025
After a few months of silence, I’m thrilled to share this promising project! To bring it to life, we need your support! Share it as much as possible and join us in making this project a reality! Help us here: gofund.me/15cbe96b #AcademicSky
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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · 08/01/2025
🎉 Happy New Year! Wishing everyone a successful 2025! This year is special as we officially launch our lab! Follow the lab account for updates on research into Ehlers-Danlos syndrome (#EDS), other genetic rheumatologic conditions, and osteoarthritis. Stay tuned! #AcademicSky #EDS #Health
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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · 31/12/2024
🎉🧪 As 2024 comes to a close, let's play together and share a published paper from 2024 that inspired you or made a significant impact in your field.🌟 Together, we can create a thread of knowledge and inspiration to kick off 2025 stronger than ever! 🚀 #AcademicSky #PhDSky #MedSky
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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · 29/12/2024
I was very lucky to see beautiful Cloud iridescence this morning all over the city! #Cloud #Nature #Norway
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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · 24/12/2024
🎄 Merry Christmas! 🎉 May your holidays be filled with joy and relaxation. Let's recharge and gear up for a 2025 brimming with success and grants and publications ! 🧾✨ #lab&fun #academicsky #medsky
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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · 21/12/2024
🌟 Happy Winter Solstice and Happy Holidays! 🌟 In Trondheim, today, the sunrise was at 10:01 AM and the sunset at 2:31 PM. It's comforting to know that the days will soon start getting longer. (and don't forget your D-vitamin !) ❄️✨ #AcadelicSky
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Reposted by Benjamin Brigant, PhD
OhTWIST @ohtwist.bsky.social · 15/12/2024
Differences in manifestations of Marfan syndrome, Ehlers-Danlos syndrome and Loeys-Dietz syndrome 2017: www.ncbi.nlm.nih.gov/pmc/articles... #EDS #LDS #Mafran #CTD #meded #FOAMed #medicine #doctors #genetics #MedSky
ncbi.nlm.nih.gov
Differences in manifestations of Marfan syndrome, Ehlers-Danlos syndrome, and Loeys-Dietz syndrome
Many different heritable connective tissue disorders (HCTD) have been described over the past decades. These syndromes often affect the connective tissue of various organ systems, including heart, blo...
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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · 11/12/2024
Do you want a nice Christmas song in your lab ? I always love the #acapellascience work! He transforms science into amazing songs 😍 #AcademicSky #medsky #lab&fun
youtube.com
❄️ single cells, single cells! ❄️ #acapella #science #christmas
YouTube video by acapellascience
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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · 10/12/2024
🌍🧪 Want to do something different and have fun? Try Skype a Scientist! It's an amazing chance to connect with a classroom anywhere in the world 🌎 and share your journey as a scientist. 👩‍🔬 The new 2025 volunteer form is out 🥳 Let’s inspire the next generation! 💡✨ #PhDSky #AcademicSky #MedSky
skypeascientist.com
SKYPE A SCIENTIST
Skype a Scientist matches your classroom, scout troop, or library with scientists for Q&A sessions for free!
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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · 07/12/2024
Use the #lab&fun and #ScienceJokes to develop the feed: bsky.app/profile/did:...
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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · 25/11/2024
#AcademicSky
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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · 20/11/2024
Congratulations to the team for this work! An innovative way to use #CRISPR 🧬 ! This study uses CRISPR-gRNA to barcode small extracellular vesicles, enabling subpopulation-specific analysis of their biogenesis and release. A groundbreaking tool for studying sEV heterogeneity! #MolecularBiology
nature.com
Barcoding of small extracellular vesicles with CRISPR-gRNA enables comprehensive, subpopulation-specific analysis of their biogenesis and release regulators - Nature Communications
The release processes of small extracellular vesicles (sEVs) remain poorly understood despite their importance. Here, Kunitake et al. present a screening platform called CIBER screening that enables e...
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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · 16/11/2024
#AcademicSky You can use the tag #lab&fun or #ScienceJokes to share your best funny meme or jokes in the feed ! (And you can join the feed here: bsky.app/profile/did:... )
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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · 14/11/2024
#AcademicSky, #molecularbiology #CRISPR Let's get to know each other! Quote this & tell me: 1) a project you are working on & 2) an odd idea/theory you aren't working on but keep thinking about. 1) development of nanoparticles to treat arthritis 2) fundraising for academic research
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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · 13/11/2024
With so many new people joining, here’s a great resource for both new and seasoned science fans! @mIT just released a curated list of must-follow accounts to keep up with the latest research and discoveries. Check it out! #academicsky #molecularbiology
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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · 12/11/2024
In October, I had the chance to travel to Brussels to attend the Osteoarthritis Foundation Gala at the beautiful Chalet Robinson. An unforgettable experience for us as young scientists! (Thread) #academicsky #OsteoArthritis
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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · 09/11/2024
Very exciting to see the first clinical trial with CRISPR/Cas13 in action! Targeting RNA offers distinct advantages over DNA-targeting approaches and I’m convinced Cas13 holds great promise for the future of gene editing therapies. #CRISPR #molecularbiology
crisprmedicinenews.com
News: FDA Clears First CRISPR-Cas13 RNA-Editing Trial for Macular Degeneration - CRISPR Medicine
The FDA has cleared HuidaGene Therapeutics' investigational new drug application for HG202, the first CRISPR-Cas13 RNA-editing therapy to enter clinical trials. HG202 is designed to treat neovascular age-related macular degeneration, which is a leading cause of blindness in people over the age of 60.
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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · 29/10/2024
CRISPR News! 🧬 CRISPR isn’t just about DNA “scissors”! Scientists at Rockefeller and MSKCC found that CRISPR-Cas10, a different type, works like a molecular fumigator. It floods infected bacteria with toxic molecules to stop viruses in their tracks. #CRISPR #Genetics #Microbiology
rockefeller.edu
A new chemistry for CRISPR - News
It acts as a sort of molecular fumigator to battle phages and plasmids.
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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · 20/03/2024
I enjoyed joining a new adventure with bright 10-11 year olds via www.skypeascientist.com! We dived into the world of genetics, exploring the 'superpowers' hidden in our DNA. I recommend this to everyone! #YoungScientists #academicsky
skypeascientist.com
SKYPE A SCIENTIST
Skype a Scientist matches your classroom, scout troop, or library with scientists for Q&A sessions for free!
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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · 30/12/2023
🎉🧪 As 2023 comes to a close, let's highlight the year's most impactful research! 🌍🧬 Share a published paper from 2023 that inspired you or made a significant impact in your field. Comment below with the link! Let's create a thread of knowledge and inspiration for 2024 #AcademicSky #PhDSky
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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · 27/12/2023
Good reading for the holiday season! Emma Xu's inspiring journey from homelessness to a Ph.D. is a heartwarming story of resilience and determination. A perfect reminder of what's possible in life. Good luck with your research, Emma! #AcademicJourney #Inspiration #academicsky #PhDchat #PhDsky
science.org
From homeless to Ph.D.: How I found my way into research
“For much of my scientific training I feared I was behind my peers,” this grad student writes
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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · 25/12/2023
🎄 Merry Christmas! 🎉 May your holidays be filled with joy and relaxation. Let's recharge and gear up for a 2024 brimming with success and breakthroughs! 🚀✨ #lab&fun #academicsky
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Reposted by Benjamin Brigant, PhD
TRAstonDrs @castltrastondrs.medsky.network · 18/12/2023
MedSky🧪 IDSky #RNA sensing in #immunity . This Cell Press Selection explores recent advances that shape our understanding of RNA in health, disease, and therapies. rna-sensing-in-immunity.elsevierdigitaledition.com?__hstc=25856...
Cover page
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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · 28/11/2023
🧬 Exciting breakthrough in CRISPR research! A new algorithm by Feng Zhang's team at the Broad Institute has uncovered 188 rare CRISPR systems, revealing a diverse treasure trove of editing tools. This could lead to more precise gene editing with fewer side effects. #CRISPR #MolecularBiology
science.org
Uncovering the functional diversity of rare CRISPR-Cas systems with deep terascale clustering
A clustering algorithm, FLSHclust, was developed and applied to discover 188 previously unreported CRISPR-linked gene modules.
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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · 25/11/2023
Very excited to see Canada's integration into Horizon Europe's funding pillar 2! 🌍🇨🇦 This opens up incredible opportunities for collaboration. Can't wait to work alongside my Canadian colleagues on groundbreaking projects! #HorizonEurope #Canada #academicsky
ec.europa.eu
Press corner
Highlights, press releases and speeches
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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · 24/11/2023
Yesterday's COST Action NetwOArk meet-up for Working Group 2 was so interesting as always! From brainstorming novel projects to discussing the review writing, we're pushing boundaries! Excited for upcoming training schools and webinars. Together, let's combat OA! #NetwOArk #OAResearch #CostAction🔬📚
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Reposted by Benjamin Brigant, PhD
Sarah McAnulty, Ph.D. @sarahmackattack.bsky.social · 16/11/2023
We want to hit about 700 more classrooms this year. That's a lot of classrooms! Help us out by telling a friend that we're here to match classrooms libraries, scout troops, and more with scientists. SkypeAScientist.com is here to help!
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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · 15/11/2023
Exciting insights from a recent article on CRISPR Cas13! It emphasizes the importance of judicious application and suggests moving towards alternatives to lentiviruses in future research. #CRISPR #MolecularBiology
nature.com
Intrinsic RNA-targeting activity limits the applicability of CRISPR–Cas13 - Nature Biomedical Engi...
We revealed that the RNA-targeting activity of the Cas13 family of nucleases allows them to directly target endogenous RNA in mammalian cells. Such activity limits the usage of lentiviral Cas13 system...
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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · 03/11/2023
Excited to share our latest research! 🎉 Just published a new article contributing to #COVID19 research. Grateful for the collaboration - it's been a fantastic journey working together. Let's keep pushing boundaries in science. 🧪🔬 #Virology #COVID19Research #academicsky
jbc.org
Reversible and irreversible inhibitors of coronavirus Nsp15 endoribonuclease
The emergence of SARS-CoV-2, the causative agent of COVID-19, has resulted in the largest pandemic in recent history. Current therapeutic strategies to mitigate this disease have focused on the develo...
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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · 29/10/2023
Stumbled upon this brilliant Halloween setup in the neighborhood! 👻 A clever nod to combating misinformation. Love seeing creativity and important messages combined! 🎃 #academicsky #Hallosky #funandscience
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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · 28/10/2023
#crispr
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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · 20/10/2023
Today we celebrate #WorldCRISPRDay, marking 11 incredible years since the CRISPR/Cas9 was shared in Science! 🎉E. Charpentier & J. Doudna’s work revolutionized molecular biology. Immerse yourself in the original paper to explore the genesis of this discovery! 🧬 #molecularbiology #CRISPR #academicsky
science.org
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
A prokaryotic RNA–directed targeting system can be designed to cleave any DNA sequence.
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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · 19/10/2023
#lab&fun !
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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · 14/10/2023
Remembering Hubert Reeves: A brilliant mind who had the rare gift of making the complexities of the universe accessible to all. His passion for science and eloquent explanations made the stars a little closer to our understanding. A true inspiration and loss for our global community. 🌌 #Academicsky
en.m.wikipedia.org
Hubert Reeves - Wikipedia
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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · 10/10/2023
Wishing all of our Canadian friends and colleagues a joyful and delicious Thanksgiving! May your day be filled with love, gratitude, and the warmth of close ones around the table. 🍁🦃 #CanadianThanksgiving #academicsky Picture: pink lake, Canada.
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Benjamin Brigant, PhD @crisprandbeyond.bsky.social · 09/10/2023
Unlocking the mysteries of disordered proteins! 🧬 A study in Nature Biotech reveals a new method, DisP-seq, to map the genome-wide binding of DNA-associated proteins with disordered regions(IDRs). IDRs play pivotal roles in cellular signaling, transcription, and more! #MolecularBiology
nature.com
A genome-wide view of disordered proteins - Nature Biotechnology
Transcription factors containing disordered regions can now be mapped across the genome, aiding functional studies.
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