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Corynn Kasap MD PhD @corynnkasap.bsky.social · 25/08/2025

We are excited about the potential for anti-CD70 CAR-Ts to make a difference for high-risk #myeloma patients

Corynn Kasap MD PhD @corynnkasap.bsky.social · 25/08/2025

Special shout-out to our Junior Specialist Sanjana Prudhvi, who designed our Visual Abstract. We are lucky to work with such an amazing team, including everyone in the Wiita Lab @ucsfcancer.bsky.social and our collaborators. (10/10)

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Corynn Kasap MD PhD @corynnkasap.bsky.social · 25/08/2025

Finally, we developed a proof-of-principle dual-targeting CAR against both BCMA and CD70 as a potential strategy to avoid antigen escape–mediated resistance in #HRMM (9/10)

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Corynn Kasap MD PhD @corynnkasap.bsky.social · 25/08/2025

We also evaluated epigenetic regulation of CD70 in #myeloma, using a machine learning model to predict and then test key transcriptional regulators of surface expression (8/10)

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Corynn Kasap MD PhD @corynnkasap.bsky.social · 25/08/2025

While all anti-CD70 CARs demonstrated clear efficacy against myeloma cell line xenograft models in vivo, the CD27-based CAR showed remarkable >80-fold expansion‼️ versus scFv-based CARs, suggesting a highly favorable phenotype for clinical translation (7/10)

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Corynn Kasap MD PhD @corynnkasap.bsky.social · 25/08/2025

We then used the crystal structure of CD70 bound to its natural receptor CD27 to develop a structure-guided, optimized CD27-based CAR to compare to standard “scFv” based CAR, using frameworks containing either CD28 or 4-1BB costim domains. (6/10)

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Corynn Kasap MD PhD @corynnkasap.bsky.social · 25/08/2025

Analysis of paired tumor RNA sequencing data from ‪@themmrf.bsky.social‬ CoMMpass study, cell surface #proteomics, and flow cytometry revealed CD70 was present on primary #myeloma. CD70 transcript was strongly enriched in high risk genotypes t(4;14), gain 1q, and loss 1p (5/10)

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Corynn Kasap MD PhD @corynnkasap.bsky.social · 25/08/2025

...Samir Parekh at Icahn Mount Sinai, Stieglitz lab and the myeloma clinical group @ucsfcancer.bsky.social . Major support from Myeloma Solutions Fund, NIH NCI, and UCSF Living Therapeutics Initiative (4/10)

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Corynn Kasap MD PhD @corynnkasap.bsky.social · 25/08/2025

This work was co-led by myself, Adila Izgutdina, and @bonellpatinoe.bsky.social under mentorship of @apwiita.bsky.social, + collab w/ Ben Barwick and Larry Boise @winshipcancer.emory.edu, ‪@jdlicht.bsky.social, ‪@shanmugamlab.bsky.sociall, @kortemmelab.bsky.social, and... (3/10)

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Corynn Kasap MD PhD @corynnkasap.bsky.social · 25/08/2025

In this work we show CD70 is a novel CAR target enriched in #HRMM. We used structure-guided design to optimize a CD27-based anti-CD70 CAR-T that outperforms scFv-based CAR-Ts in preclinical efficacy studies. (2/10)

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Corynn Kasap MD PhD @corynnkasap.bsky.social · 25/08/2025

Excited to share our new manuscript, now published in Blood! BCMA #CART show impressive responses for #myeloma, but pts with high-risk cytogenetics relapse more quickly and are in urgent need of new therapies. Thread👇 (1/10) ashpublications.org/blood/articl...

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Bonell Patiño E @bonellpatinoe.bsky.social · 18/08/2025

Thrilled to share our new paper in Blood! We show that CD70 is upregulated in high-risk MM, and that a CD27-based anti-CD70 CAR-T design achieves >80-fold improved expansion in vivo. So honored to co–lead this work with @corynnkasap.bsky.social, Adila Izgutdina under @apwiita.bsky.social mentorship

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callaslilies.bsky.social @callaslilies.bsky.social · 08/03/2025

It was so much work but worth it! San Francisco really showed up! @standupforscience.bsky.social

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apwiita.bsky.social @apwiita.bsky.social · 07/03/2025

STAND UP FOR SCIENCE!✊🏽💪 Great turnout in #SanFrancisco to defend science from political attacks. Funding science is what actually makes America great vehicle for economic growth, advances in innovation, American leadership, upward mobility for Americans, and overall benefit to humanity.

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Corynn Kasap MD PhD @corynnkasap.bsky.social · 07/03/2025

Beautiful day and amazing turnout to hear keynote speaker and Nobel laureate Carolyn Bertozzi speak in San Francisco at today’s protest in defense of federal science funding #StandUpForScience2025 #StandUpForScience

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Katie Wilkinson @drkwilkinson.bsky.social · 07/03/2025

Nobel Prize winner @carolynbertozzi.bskyverified.social talking about how important science is and how we are in danger of losing decades worth of investment in science. Highlighting the danger to programs that gave her her start in science targeted for DEI & the cost of losing them

Attendees at SF Stand Up for Science with signs

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Science Magazine @science.org · 07/03/2025

Breaking news: Thousands of researchers and their supporters, including recently fired federal workers, have gathered across the U.S. in response to layoffs and funding cuts ordered by the Trump administration. scim.ag/41zlPv4

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Thousands gather across U.S. in Stand Up for Science events

Scientists rally across the country in response to layoffs and funding cuts ordered by the Trump administration

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Ardem Patapoutian @ardemp.bskyverified.social · 07/03/2025

I was bot involved in making any of the posters behind me but I agree with all of them.

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Scott Budman @scottbudman.bsky.social · 07/03/2025

#New: Huge crowd gathers for #StandUpForScience2025 rally in San Francisco:

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Haezyll @haezyll.bsky.social · 07/03/2025

San Francisco really showed up for #standupforscience2025!! Making me proud, Bay Area. 🥼🌁🌍

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Corynn Kasap MD PhD @corynnkasap.bsky.social · 07/03/2025

So happy to see so many people who want to support the fight to preserve science funding at today’s #StandUpForScience in SF @standupforscience.bsky.social

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Stand Up for Science! @standupforscience.net · 06/03/2025

SO MANY STAND UP FOR SCIENCE EVENTS TO CHOOSE FROM—153 and COUNTING! To get more information on our local events and to register your own, head to www.standupforscience2025.org/local-event-information/ ☀️⬇️🌎

List of Stand Up for Science events—official events in red, solidarity events in blue.

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Corynn Kasap MD PhD @corynnkasap.bsky.social · 28/02/2025

NIH funding of basic + translational science trainees is critical for advancing the standard of care for cancer patients. I could not have done the work I did, and want to continue to do, without the 9+ years of NIH support I have received.

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Corynn Kasap MD PhD @corynnkasap.bsky.social · 20/02/2025

NIH funding blocked: If study sections and review councils don’t meet, then grants are not awarded. “U.S. National Institutes of Health-related updates to the Federal Register… are on hold.” www.thetransmitter.org/funding/fede...

thetransmitter.org

Federal Register hold makes ‘end run’ around court pause on NIH funding freeze

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CantlonLab @cantlonlab.bsky.social · 18/02/2025

Join us! Science Homecoming helps scientists reconnect with communities by writing about the importance of science funding in their hometown newspapers. We’ve mapped every small newspaper in the U.S. and provide resources to get you started. Help science get back home 🧪🔬🧬 🏠 sciencehomecoming.com

sciencehomecoming.com

Science Homecoming

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David Shiffman, Ph.D. 🦈 @whysharksmatter.bsky.social · 18/02/2025

A proposal: Academic researchers and folks in similar positions, consider writing an op-Ed, or at least a letter to the editor, in your local paper about what these horrific decisions will do to jobs and services *in your local community*. I train scientists to write op-Ed’s and I can help.

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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 12/02/2025

Well said @dereklowe.bsky.social. Academia produces two vital products: (1) knowledge, and (2) human capital that knows how to use it. If we can’t train enough young creative US scientists to fulfill biopharma industry needs… “I think they're being short-sighted, because fear does that to you.”

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