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Jorge “Coco” Del-Aguila

@cocolucho.bsky.social
1 followers 32 following 0 posts

Omics, Hypothesis-Free, NGS, Big Data

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Reposted by Jorge “Coco” Del-Aguila
Chris Wyatt @chris-wyatt.bsky.social · 22/08/2026
nf-core/genomeqc is finally on bioRxiv,, a best-practice #Nextflow pipeline for comparing #genome & assembly quality, grown out of the 2024 @nf-co.re Barcelona hackathon with Fernando Duarte, @stephenturner.us and more.
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Stephen Turner @stephenturner.us · 21/08/2026
Discuss. openai.com/index/chatgp...
openai.com
Introducing ChatGPT for Teens: Built for learning, backed by protections
ChatGPT for Teens helps teens learn, think critically, and use AI with confidence, with stronger built-in protections, healthy-use features, and additional controls for parents.
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Reposted by Jorge “Coco” Del-Aguila
Simon Fisher @profsimonfisher.bsky.social · 21/08/2026
Hello, human geneticist here. There is no scientific basis for attempts to define people in terms of “good” or “bad” genes - these are discredited views in service of racist ideologies. For consensus & concerns of experts in our field, see e.g. this 2020 statement from @geneticssociety.bsky.social:
Statement from the American Society of Human Genetics in 2020, countering the myth of "good genes". It reads as follows:
"Genetics demonstrates that humans cannot be divided into biologically distinct subcategories or races, and any efforts to claim the superiority of humans based on any genetic ancestry have no scientific evidence. Moreover, it is inaccurate to claim genetics as the determinative factor in human strengths or outcomes when education, environment, wealth, and health care access are often more potent factors. There is no factual basis for attempts to define communities or regions of people with "good" or "bad" genes and a century of science has debunked such claims, which can feed discredited views and racist ideologies. Unchecked, unethical application of false genetic "theories" have resulted in past atrocities from forced sterilizations to the Holocaust and can still fuel unethical social policies worldwide today. Over the decades, our field also has reflected on its own role in such now-condemned ideas, and we speak out vocally as a community and as individuals to combat their resurgence.
We must protect and advance the ethical use of genetics and genomics knowledge for the profound good it can realize, including better, more precise healthcare that leverages what we are discovering about human genetic commonality and diversity. The human genetics community dedicates itself to this goal each day, and today we are improving and saving hundreds of thousands of lives. As the ASHG community focuses on realizing the benefits of human genetics and genomics research for people everywhere, we also urge societal attention to address profound educational, economic and health inequalities that fuel differences in human experience and well-being. By pursuing all of these activities, humans can celebrate our common heritage as one people, embrace and fully tap our valued diversity, and help achieve optimal life outcomes for all."
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Reposted by Jorge “Coco” Del-Aguila
Ming Tommy Tang @tommytang.bsky.social · 21/08/2026
Biological aging and generational shifts in early-onset cancer risk www.nature.com/articles/s4...
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Reposted by Jorge “Coco” Del-Aguila
Eric Fauman (he/him) @ericfauman.bsky.social · 01/02/2025
I hear there's some awards show this weekend but that's not until tomorrow. Just enough time to look at the extreme p values of the month. @gwascatalog.bsky.social just added a bunch of new lead associations to their file this week so I've cranked the numbers to find the winners.
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Reposted by Jorge “Coco” Del-Aguila
Stephen Turner @stephenturner.us · 14/01/2025
How should we test AI for human-level intelligence? OpenAI’s o3 electrifies quest www.nature.com/articles/d41586-025-…
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Reposted by Jorge “Coco” Del-Aguila
Ming Tommy Tang @tommytang.bsky.social · 14/01/2025
I promised to write an end-to-end tutorial to replicate this genomics figure during the holidays. Now it is ready 👇
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Reposted by Jorge “Coco” Del-Aguila
Gaël Varoquaux @gaelvaroquaux.bsky.social · 22/12/2024
If you work with Python dataframes (pandas, @pola.rs) and are not using skrub.TableReport, you're missing out 😀 We keep improving it
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Reposted by Jorge “Coco” Del-Aguila
Ming Tommy Tang @tommytang.bsky.social · 20/12/2024
Small-cohort GWAS discovery with AI over massive functional genomics knowledge graph www.medrxiv.org/content/10....
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Reposted by Jorge “Coco” Del-Aguila
Alexander Titus @alexandertitus.com · 03/12/2024
As controversial as they are powerful, how do we balance the risks and benefits of gene drives? And who gets to decide? www.connectedideasproject.com/p/gene-drive...
connectedideasproject.com
Gene Drives: Engineering Nature’s Future
From crops to human health, the impact is as wide as the challenges they create
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Reposted by Jorge “Coco” Del-Aguila
Stephen Turner @stephenturner.us · 04/12/2024
I'm kidding, of course (or am I?). I've been trying myself to get my Python close to parity with my #Rstats fluency. Some resources that helped me: blog.stephenturner.us/p/python-for...
blog.stephenturner.us
Python for R users
A Google search for “R vs Python” returns thousands of hits across sites like Reddit, IBM, Datacamp, Coursera, Kaggle, and many others.
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Reposted by Jorge “Coco” Del-Aguila
Jeffrey Ross-Ibarra @jrossibarra.bsky.social · 04/12/2024
Just your regular reminder how awesome this review on inbreeding depression is. www.nature.com/articles/nrg...
nature.com
The genetics of inbreeding depression - Nature Reviews Genetics
The genetic basis of inbreeding depression and of the related phenomenon, heterosis, has been a puzzle for many decades. Based on recent studies in many species, the authors argue that both phenomena ...
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Reposted by Jorge “Coco” Del-Aguila
UCDavisPlants @ucdavisplants.bsky.social · 04/12/2024
🌱 UC Davis team presents research on how genes and temperature affect bean seed colors. The study explores how genetics and environment interact for unique patterns! ▶️ onlinelibrary.wiley.com/doi/10.1111/... #CropScience #Genetics #SustainableAg #PlantBreeding
onlinelibrary.wiley.com
Seed color patterns in domesticated common bean are regulated by MYB‐bHLH‐WD40 transcription factors and temperature
Color patterning is an inherent fitness factor in wild plants and animals. In domesticated plants, color patterns serve as key farmer and consumer recognition and acceptance factors. This study propo....
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Reposted by Jorge “Coco” Del-Aguila
Stephen Turner @stephenturner.us · 05/12/2024
Nice post from @djnavarro.net on making tables in #Rstats with table1 blog.djnavarro.net/posts/2024-06-21…
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Reposted by Jorge “Coco” Del-Aguila
Ming Tommy Tang @tommytang.bsky.social · 05/12/2024
I hope you've found this post helpful. Follow me for more. Subscribe to my FREE newsletter divingintogeneticsandgenomics.ck.page/profile
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Reposted by Jorge “Coco” Del-Aguila
Stephen Turner @stephenturner.us · 26/11/2024
bamSliceR: a Bioconductor package for rapid, cross-cohort variant analysis www.biorxiv.org/content/10.1101/202… 🧬🖥️🧪 #rstats github.com/trichelab/bamSliceR from @timtriche.bsky.social lab
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Reposted by Jorge “Coco” Del-Aguila
Ming Tommy Tang @tommytang.bsky.social · 26/11/2024
Pylustrator offers an interactive interface to find the best way to present your data in a figure for publication. Added formatting and styling can be saved by automatically generated code. pylustrator.readthedocs.io/en/latest #python
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Reposted by Jorge “Coco” Del-Aguila
Stephen Turner @stephenturner.us · 26/11/2024
Seconded. I use the postcards #Rstats package from @seankross.com for my personal website. Just a few lines of RMarkdown and you get a very nice-looking website. GitHub README has several examples github.com/seankross/po.... Trainee? Job-hunting? Have a public website/portfolio. *Take up space.*
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Reposted by Jorge “Coco” Del-Aguila
Eric Fauman (he/him) @ericfauman.bsky.social · 24/11/2024
Important corollary! With gene duplication we usually preserve molecular function (eg deimination) but not biological role (eg hair formation). Since nearby genes often come from paralogs this means nearby genes seldom share a biological pathway, unlike what we see in bacterial operons
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Reposted by Jorge “Coco” Del-Aguila
Michael Love @mikelove.bsky.social · 06/02/2024
New sc + splicing work from Patro lab @robp.bsky.social First authors Dongze He and Yuan Gao of UMD CBCB
Probabilistic model of fragments for ambiguous reads
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Reposted by Jorge “Coco” Del-Aguila
Veera Rajagopal @doctorveera.bsky.social · 09/01/2024
open.substack.com/pub/gwasstor...
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