Alt: Robert Redford as Jeremiah Johnson Nodding, here indicating respect

Nature Metabolism - Analysing the causal links of gene expression and protein abundance on type 2 diabetes risk in blood and seven tissues related to the disease from individuals of four...

Nature Metabolism, Published online: 14 November 2025; doi:10.1038/s42255-025-01399-3In a mouse model of the rare disease citrin deficiency, the authors discovered that the accumulation of glycerol-3-phosphate leads to ChREBP activation and FGF21 induction. The study identifies glycerol-3-phosphate as a ChREBP-activating ligand, which could resolve paradoxes of FGF21 expression and clarify the logic of lipogenic transcription.

To investigate the underlying mechanisms of complex traits, we performed an eQTL meta-analysis in skeletal muscle and identified 18,818 conditionally distinct signals for 12,283 genes. Colocalization ...

Citrin Deficiency (CD) is caused by inactivation of SLC25A13, a mitochondrial membrane protein required to move electrons from cytosolic NADH to the mitochondrial matrix in hepatocytes. People with CD...