iiinova — where your digital self keeps evolving

Clayton Mansel @claytonmansel.bsky.social · 24/01/2026

open.substack.com/pub/overfitt...

Clayton Mansel @claytonmansel.bsky.social · 12/11/2025

This week I wrote about a provocative new study in Mol Psychiatry. The authors claim that most studies of post-mortem human brain tissue are invalid because the gene expression patterns change. I read it closely and I am…. not convinced. See why ⬇️ open.substack.com/pub/overfitt...

open.substack.com

You can't correlate your way to causation

A new study of living brain gene expression could change neuroscience forever... if we believe it

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Clayton Mansel @claytonmansel.bsky.social · 29/07/2025

Come check out poster #745 at #AAIC and learn about how a healthy lifestyle can mitigate genetic predisposition to Alzheimer’s Disease!

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Clayton Mansel @claytonmansel.bsky.social · 27/05/2025

🎉📄Excited to share a pre-print of my most recent PhD project: "Downward bias in the association between APOE and Alzheimer’s Disease using prevalent and by-proxy disease sampling in the All of Us Research Program" (short summary and link in replies ⬇️)

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Clayton Mansel @claytonmansel.bsky.social · 06/05/2025

Jeremy in the trenches fighting for all of us! 👏

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Clayton Mansel @claytonmansel.bsky.social · 10/04/2025

Really excellent keynote speaker @bionexuskc.bsky.social by Dr. Tatonetti and well said - “observation is the starting point of biological discovery.”

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Mark Hoffman @markhoffmankc.bsky.social · 10/04/2025

Congrats to @claytonmansel.bsky.social for his Nexus informatics poster receiving an honorable mention. @bionexuskc.bsky.social

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Jeremy Berg @jeremymberg.bsky.social · 18/02/2025

Just watched Secretary Kennedy's Speech to HHS Employees. Key takeaways: (1) NO ANNOUNCEMENT OF FIRINGS! (2) Generally positive tone about science and scientists (3) Set up some strawmen about lack of transparency but promising a new era of transparency 1/2

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Pete Buttigieg @petebuttigieg.bsky.social · 17/02/2025

If you wanted to cut waste, fraud, and abuse, you would empower the inspectors general. If you wanted more waste, fraud, and abuse, you would fire them.

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Eric Topol @erictopol.bsky.social · 12/02/2025

Defying defiance to the laws. Good for NIH!

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Clayton Mansel @claytonmansel.bsky.social · 07/02/2025

This administration is determined to implement their priorities in the most bad-faith, disruptive way possible. If we are all about “merit” now why not just merge the Diversity F’s with the others? Ridiculous

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Reposted by Clayton Mansel

Jeff Weiner @jlweiner.bsky.social · 05/02/2025

The CSR comm I'm on just pulled all Diversity F grants from the current review cycle. These apps are reviewed alongside (and by the same criteria) as all other F grants. So, instead of helping these trainees, they will actually be punished by having their grant reviews delayed at least 1 cycle !?!?

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nilay patel @reckless.bsky.social · 25/01/2025

Totally normal stuff here

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Celia Ford @celiaford.bsky.social · 23/01/2025

Hi, Vox reporter here: If you've had a study section, NIH travel, or other NIH-related meeting cancelled (or not), raise your hand! Reply or DM me, and repost for visibility if you're able. #academicsky @drugmonkey.bsky.social

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Clayton Mansel @claytonmansel.bsky.social · 23/01/2025

This going to be so good and probably one of the most useful streetcar routes in the U.S. Can’t wait to ride!

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KC Streetcar @kcstreetcar.org · 23/01/2025

We are absolutely swooning over these pics of #kcstreetcar 807 rolling through the Plaza on its 1st ever test run. 😍

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S. Trent Rosenbloom @trentrosenbloom.bsky.social · 18/01/2025

One day, one toe in the water with Ambient AI Scribes. Interesting. I did not find it to be a game changer for documentation burden, but perhaps it is a paradigm shift back to being able to capture patient stories with detail and expressivity in a way busy clinicians may struggle to do. 9/x

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Clayton Mansel @claytonmansel.bsky.social · 09/01/2025

Excited to share a preprint of my first project from my PhD: Distinct Medical and Substance Use Histories Associate with Cognitive Decline in Alzheimer's Disease! 🧠 doi.org/10.1101/2024...

Graph showing individuals with a cardiovascular disease history with worsening cognitive decline relative to others

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Clayton Mansel @claytonmansel.bsky.social · 23/11/2024

I’m no fan of echo chambers but the critics of movers to Bluesky under-appreciate: 1) X has become the same thing but for the other side 2) X’s culture has bent to the whims of its owner (which is fine! But he’s not my style) 3) X’s algorithm rewards divisive, loud, controversial takes.

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Clayton Mansel @claytonmansel.bsky.social · 21/11/2024

Just yesterday I was scrolling at the *other* place and lamenting that institutions like my library haven’t made the switch… well, today is a new day! Welcome KC library @kclibrary.bsky.social ! 📚 Maybe bsky will become a thing after all

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Clayton Mansel @claytonmansel.bsky.social · 14/11/2024

First day on Bluesky and @theverge.com has reactivated their account and Mark Cuban is posting about RSS feeds and I am so here for it

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