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Cole Korponay

@ckorponay.bsky.social
99 followers 247 following 32 posts

🧠 Instructor in Psychiatry @ Harvard Medical School | McLean Hospital | Trying to squeeze better brain juice from fMRI

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Reposted by Cole Korponay
Communications Biology @commsbio.nature.com · 27/08/2026
🧠 Individual differences in arousal, indexed by a non-neuronal fMRI signal, are strongly associated with variation in functional brain network connectivity. Effects replicate within and across samples and are altered by catecholaminergic manipulation. PDF available: www.nature.com/articles/s42...
nature.com
Physiological arousal as a predominant source of individual differences in functional brain networks - Communications Biology
Individual differences in arousal, indexed by a non-neuronal fMRI signal, are strongly associated with variation in functional brain network connectivity. Effects replicate within and across samples a...
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Cole Korponay @ckorponay.bsky.social · 27/08/2025
And yes, sLFO changes in response to drug administration appear to be most directly driven by changes in cerebral blood flow that stem from arousal-related physiological changes (e.g., to breathing and heart rates) attributable to the drug.
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Cole Korponay @ckorponay.bsky.social · 27/08/2025
Great questions! The sLFO is a non-neuronal component of the global signal (which includes both neuronal and non-neuronal components). If you're interested in getting the cleanest read-out of neuronal signals possible, then regressing out the sLFO is always going to help with that.
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Cole Korponay @ckorponay.bsky.social · 26/08/2025
An exciting 🆕 extension of our sLFO/FC inflation work (www.nature.com/articles/s41...) Extracting the sLFO signal from BOLD data not only sharpens FC estimates.. ..the sLFO itself - via links to arousal - captures variability in trait + state drug use phenotypes: tinyurl.com/msanmrnc #neuroimaging
medrxiv.org
Systemic physiological "noise" in fMRI has clinical relevance
Functional magnetic resonance imaging (fMRI) is central to studying neurobiological mechanisms, yet fMRI has limited clinical utility, highlighting the need for novel approaches. We show that a compon...
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Cole Korponay @ckorponay.bsky.social · 13/08/2025
How do we focus on the task in front of us amidst emotionally salient distractors? Our new paper details the numerous cogs churning simultaneously in the brain to stave off "emotion interference" and focus on task goals www.nature.com/articles/s42... #neuroimaging #neuroskyence #compneurosky
nature.com
Disentangling large-scale brain dynamics and their links to behavior during the emotional face matching task - Communications Biology
Tensor independent component analysis reveals the concurrent brain processes at work during emotion interference suppression and how individual differences relate to cognitive fitness.
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Cole Korponay @ckorponay.bsky.social · 10/07/2025
What's the take-away? Measurements of non-cognitive mental health and measurements of brain function during common fMRI tasks have little to do with one another Akin to cardiac stress tests, more affectively provocative tasks may be needed to evoke🧠activity w/ MH relevance
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Cole Korponay @ckorponay.bsky.social · 10/07/2025
We also found that: 1) Brain data and mental health data sorted subjects into discordant sets of subtypes 2) Subjects' relatively similar evoked brain activity profiles failed to reflect the comparatively diverse set of mental health profiles across subjects
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Cole Korponay @ckorponay.bsky.social · 10/07/2025
Multi-network based prediction was also only successful for cognition and proc speed. Importantly, the composite scores used for each MH domain all had high measurement reliability and similar interindividual variability.
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Cole Korponay @ckorponay.bsky.social · 10/07/2025
Across all 77 networks, none robustly or reproducibly encoded #WellBeing, #Internalizing or #SubstanceUse, even during tasks w/ socioemotional content. Instead,🧠network activity near-exclusively encoded individual differences in #cognition across all paradigms.
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Cole Korponay @ckorponay.bsky.social · 10/07/2025
In our new paper, we searched for markers of normative MH variability in all the evoked🧠networks we could find across a slew of fMRI paradigms w/ putative MH relevance (We've released maps of all 77 networks in a new "Task-Evoked Network Atlas"): identifiers.org/neurovault.c...
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Cole Korponay @ckorponay.bsky.social · 10/07/2025
#MentalHealth status is written somewhere in #Brain activity But even in today’s most marvelously modeled, spotlessly cleaned🧠data, the writing is barely legible Why? Perhaps,🧠activity evoked by typical🧠scanning conditions just has little MH info🧵 biorxiv.org/content/10.1...
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Cole Korponay @ckorponay.bsky.social · 10/07/2025
Multi-network based prediction was also only successful for cognition and proc speed. Importantly, the composite scores used for each MH domain all had high measurement reliability and similar interindividual variability.
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Cole Korponay @ckorponay.bsky.social · 10/07/2025
Across all 77 networks, none robustly or reproducibly encoded #WellBeing, #Internalizing or #SubstanceUse, even during tasks w/ socioemotional content. Instead,🧠network activity near-exclusively encoded individual differences in #cognition across all paradigms.
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Cole Korponay @ckorponay.bsky.social · 10/07/2025
In our new paper, we searched for markers of normative MH variability in all the evoked🧠networks we could find across a slew of fMRI paradigms w/ putative MH relevance (We've released maps of all 77 networks in a new "Task-Evoked Network Atlas"): identifiers.org/neurovault.c...
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Cole Korponay @ckorponay.bsky.social · 27/05/2025
And it's not to pick on you guys or this paper - I know your group does fantastic, super high-quality work. It's just because this confound becomes especially pernicious in arousal change manipulations. I'll leave things there, but again happy to help if want to check this out in your PIDT sample
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Cole Korponay @ckorponay.bsky.social · 27/05/2025
Yes, pro physio signals (sLFO a physio signal too, detectable w/ finger pulse oximeter). But our core disagreement isn't about classic physio signals vs sLFO signal, it's about need to model these signals with their regional heterogeneity in mind (see tinyurl.com/442m7hnj); that's key of Riptide
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Cole Korponay @ckorponay.bsky.social · 24/05/2025
Where (in sensorimotor cortices) we’ve shown that changes in arousal have the largest effect on sLFO-driven FC distortion
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Cole Korponay @ckorponay.bsky.social · 24/05/2025
That’s my point tho - it’s precisely stimulants’ affect on arousal (and therefore on the sLFO) that leads to my concern about the FC estimates being distorted, esp in the high vessel density areas of sensorimotor cortices
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Cole Korponay @ckorponay.bsky.social · 24/05/2025
I wasn't involved in developing it and stand to gain nothing by anyone using it. I just think it's highly relevant to this dataset, and that there's strong reason to think it may clarify something important that standard physio regression may miss.
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Cole Korponay @ckorponay.bsky.social · 24/05/2025
Definitely agree there about stimulants increasing arousal
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Cole Korponay @ckorponay.bsky.social · 24/05/2025
Oh for sure, definitely wasn't suggesting this for the ABCD dataset - but perhaps for some subset of the smaller replication dataset
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Cole Korponay @ckorponay.bsky.social · 24/05/2025
This is cool and looks like it captures something similar!
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Cole Korponay @ckorponay.bsky.social · 24/05/2025
Correct
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Cole Korponay @ckorponay.bsky.social · 24/05/2025
Yes
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Cole Korponay @ckorponay.bsky.social · 24/05/2025
I just think if the basis for the claims of which functional domains are affected by stimulants is resting on which brain networks are changing, we'd want to be sure its actually the brain networks that are changing and not a noise signal that's just making it look like they're changing
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Cole Korponay @ckorponay.bsky.social · 24/05/2025
The issue is that the sLFO signal is not only temporally variable, it's spatially variable within the brain. One of RIPTiDe's key features is that is performs voxel-specific regressions to deal with this, & its only able to do this bc it directly models the signal (which physio recordings don't)
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Cole Korponay @ckorponay.bsky.social · 24/05/2025
Especially when comparing a low-arousal scan (off-stimulant) to a high-arousal scan (on-stimulant), I would bet a significant portion of the observed increase in FC in/between sensorimotor cortices is just the inflated sLFO signal (which again is not reflecting anything brain-function related)
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Cole Korponay @ckorponay.bsky.social · 24/05/2025
So leaving it in the data isn't providing some alternative/meaningful index of brain function. It's meaningful only in the sense that it's indexing arousal level. Beyond that, it's just distorting the estimates of neuronal connectivity.
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Cole Korponay @ckorponay.bsky.social · 24/05/2025
sLFO signal isn't brain function-related - neuronal or otherwise. It's measurable in your toes. It's an epiphenomenon of arousal-driven changes in blood flow dynamics. That sLFO signal is disproportionately larger in sensorimotor cortices likely reflects greater blood vessel density in these regions
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Cole Korponay @ckorponay.bsky.social · 24/05/2025
E.g.: www.nature.com/articles/s41...
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Cole Korponay @ckorponay.bsky.social · 24/05/2025
Cool work - tho the stimulant/sleep-related FC changes in motor/visual/auditory areas strikingly resemble the arousal-driven non-neuronal sLFO changes we identified that inflate/deflate FC. Hard to know what’s real (neuronal) without denoising through RIPTiDe. Happy to assist if of interest..
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Cole Korponay @ckorponay.bsky.social · 07/04/2025
Hey friends, Wed at 9:30a ET I'll be giving a public talk on our recent work (tinyurl.com/3jatmf9e) + what's next.. "Inflating brain connections: how blood, arousal and the brain conspired to fool 🧠imagers" Tune in here! us06web.zoom.us/j/8805219099... (Meeting ID 880 5219 0990; Passcode 673919)
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Reposted by Cole Korponay
Laura Murray @lauramurrayphd.bsky.social · 13/03/2025
I'm happy to share our paper in @npp-journal.bsky.social on rsFC, cue-reactivity, and craving in nicotine smoking AND vaping! Thanks to coauthors, @amy.janeslab.org @blaisefrederick.bsky.social @ckorponay.bsky.social @mariascavnicky.bsky.social Here's what we found 🧵 www.nature.com/articles/s41...
nature.com
Brain reactivity to nicotine cues mediates the link between resting-state connectivity and cue-induced craving in individuals who smoke or vape nicotine - Neuropsychopharmacology
Neuropsychopharmacology - Brain reactivity to nicotine cues mediates the link between resting-state connectivity and cue-induced craving in individuals who smoke or vape nicotine
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Reposted by Cole Korponay
bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 27/12/2024
Differentiating BOLD and non-BOLD signals in fMRI time series using cross-cortical depth delay patterns www.biorxiv.org/content/10.1101/202…
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Cole Korponay @ckorponay.bsky.social · 18/12/2024
How do little ol' 💊s come to perturb big ol' 🧠 networks? In new work led by Justine Hill, we show that small but widespread effects on individual connections, which in aggregate can reconfigure regional input profiles, are key: onlinelibrary.wiley.com/doi/full/10.... Also, hello #Neuro Bluesky!
onlinelibrary.wiley.com
Catecholaminergic Modulation of Large‐Scale Network Dynamics Is Tied to the Reconfiguration of Corticostriatal Connectivity
At rest, the dopamine/norepinephrine agonist, methylphenidate, enhances time spent in external and internal attentional neurobiological states (DAN and DMN, respectively), suggesting the brain is pri...
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