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Cole Korponay

@ckorponay.bsky.social
99 followers 247 following 32 posts

🧠 Instructor in Psychiatry @ Harvard Medical School | McLean Hospital | Trying to squeeze better brain juice from fMRI

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Reposted by Cole Korponay
Communications Biology @commsbio.nature.com · 27/08/2026
🧠 Individual differences in arousal, indexed by a non-neuronal fMRI signal, are strongly associated with variation in functional brain network connectivity. Effects replicate within and across samples and are altered by catecholaminergic manipulation. PDF available: www.nature.com/articles/s42...
nature.com
Physiological arousal as a predominant source of individual differences in functional brain networks - Communications Biology
Individual differences in arousal, indexed by a non-neuronal fMRI signal, are strongly associated with variation in functional brain network connectivity. Effects replicate within and across samples a...
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Cole Korponay @ckorponay.bsky.social · 26/08/2025
An exciting 🆕 extension of our sLFO/FC inflation work (www.nature.com/articles/s41...) Extracting the sLFO signal from BOLD data not only sharpens FC estimates.. ..the sLFO itself - via links to arousal - captures variability in trait + state drug use phenotypes: tinyurl.com/msanmrnc #neuroimaging
medrxiv.org
Systemic physiological "noise" in fMRI has clinical relevance
Functional magnetic resonance imaging (fMRI) is central to studying neurobiological mechanisms, yet fMRI has limited clinical utility, highlighting the need for novel approaches. We show that a compon...
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Cole Korponay @ckorponay.bsky.social · 13/08/2025
How do we focus on the task in front of us amidst emotionally salient distractors? Our new paper details the numerous cogs churning simultaneously in the brain to stave off "emotion interference" and focus on task goals www.nature.com/articles/s42... #neuroimaging #neuroskyence #compneurosky
nature.com
Disentangling large-scale brain dynamics and their links to behavior during the emotional face matching task - Communications Biology
Tensor independent component analysis reveals the concurrent brain processes at work during emotion interference suppression and how individual differences relate to cognitive fitness.
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Cole Korponay @ckorponay.bsky.social · 10/07/2025
#MentalHealth status is written somewhere in #Brain activity But even in today’s most marvelously modeled, spotlessly cleaned🧠data, the writing is barely legible Why? Perhaps,🧠activity evoked by typical🧠scanning conditions just has little MH info🧵 biorxiv.org/content/10.1...
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Cole Korponay @ckorponay.bsky.social · 07/04/2025
Hey friends, Wed at 9:30a ET I'll be giving a public talk on our recent work (tinyurl.com/3jatmf9e) + what's next.. "Inflating brain connections: how blood, arousal and the brain conspired to fool 🧠imagers" Tune in here! us06web.zoom.us/j/8805219099... (Meeting ID 880 5219 0990; Passcode 673919)
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Reposted by Cole Korponay
Laura Murray @lauramurrayphd.bsky.social · 13/03/2025
I'm happy to share our paper in @npp-journal.bsky.social on rsFC, cue-reactivity, and craving in nicotine smoking AND vaping! Thanks to coauthors, @amy.janeslab.org @blaisefrederick.bsky.social @ckorponay.bsky.social @mariascavnicky.bsky.social Here's what we found 🧵 www.nature.com/articles/s41...
nature.com
Brain reactivity to nicotine cues mediates the link between resting-state connectivity and cue-induced craving in individuals who smoke or vape nicotine - Neuropsychopharmacology
Neuropsychopharmacology - Brain reactivity to nicotine cues mediates the link between resting-state connectivity and cue-induced craving in individuals who smoke or vape nicotine
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Reposted by Cole Korponay
bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 27/12/2024
Differentiating BOLD and non-BOLD signals in fMRI time series using cross-cortical depth delay patterns www.biorxiv.org/content/10.1101/202…
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Cole Korponay @ckorponay.bsky.social · 18/12/2024
How do little ol' 💊s come to perturb big ol' 🧠 networks? In new work led by Justine Hill, we show that small but widespread effects on individual connections, which in aggregate can reconfigure regional input profiles, are key: onlinelibrary.wiley.com/doi/full/10.... Also, hello #Neuro Bluesky!
onlinelibrary.wiley.com
Catecholaminergic Modulation of Large‐Scale Network Dynamics Is Tied to the Reconfiguration of Corticostriatal Connectivity
At rest, the dopamine/norepinephrine agonist, methylphenidate, enhances time spent in external and internal attentional neurobiological states (DAN and DMN, respectively), suggesting the brain is pri...
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