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Chymkowitch lab

@chymkowitchlab.bsky.social
265 followers 83 following 38 posts

Associate Professor at the university of Oslo

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Anthony Mathelier @amathelier.bsky.social · 18/08/2026
New role alert 🧬 Excited to take over as co-lead of the ELIXIR Norway node at @uio.no, alongside @edv.bsky.social, to support life science infrastructure in Norway and across @elixir-europe.org . elixir.no/news/2026/ui...
elixir.no
New Node Leaders at the University of Oslo - ELIXIR Norway
Prof. Eivind Valen and Dr Anthony Mathelier are now taking over as leaders of the ELIXIR node at the University of Oslo, succeeding Prof. Rein Aasland.
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Chymkowitch lab @chymkowitchlab.bsky.social · 12/06/2026
Energised after an inspiring group retreat at the top of Kolsås. Great group members, great weather, great views. Ready for the fun science ahead! @biovitenskap.bsky.social
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Chymkowitch lab @chymkowitchlab.bsky.social · 04/06/2026
Congratulations @helene-knavelsrud.bsky.social and Jorrit Enserink. I am very happy to be a part of this project. Can’t wait for the kickoff.
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Institut Pasteur | 130 years of biomedical research @pasteur.fr · 28/05/2026
🏆 Congrats to Anne Dejean, laureate of the 2026 Shaw Prize in Life Science & Medicine, with Hugues de Thé & Zhu Chen, for pioneering work that turned acute promyelocytic leukemia into a >90% curable cancer. 🔗 www.shawprize.org/.../life-sci...
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Anthony Mathelier @amathelier.bsky.social · 01/06/2026
🎉 The CBGR group turns 10! We just celebrated with collaborators, colleagues, friends & family. This milestone belongs to everyone involved; too many to name, but every single one of you made it happen. 🙏 Here's to the next 10 years! 🥂 @uio.no @nordicembl.bsky.social @ncmbm.bsky.social
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Department of Biosciences, University of Oslo @biovitenskap.bsky.social · 01/06/2026
Can cells remember being starved, and does that memory change how they behave in the future? This fundamental biological question is investigated by the research project called "Total Recall". It's funded with 40 million NOK through the "Toppforskere" programme from the Research Council of Norway
mn.uio.no
Total Recall: Major grant to uncover how cells remember starvation - Department of Biosciences
A team of researchers from the University of Oslo has been awarded 40 million NOK from the Research Council of Norway to investigate a fundamental biological question: Can cells remember being starved...
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Chymkowitch lab @chymkowitchlab.bsky.social · 19/03/2026
Always a pleasure to work with you!
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Chymkowitch lab @chymkowitchlab.bsky.social · 19/03/2026
#NucleicAcidsResearch #Epigenetics #Adipocytes #Metabolism #UCP1 #SUMOylation @ncmbm.bsky.social
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Chymkowitch lab @chymkowitchlab.bsky.social · 19/03/2026
Research supported by @biovitenskap.bsky.social @uio.no The Research Council of Norway, UNIFOR, @kreftforningen.
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Chymkowitch lab @chymkowitchlab.bsky.social · 19/03/2026
These results suggest that temporally controlled SUMO pathway inhibition could be a novel strategy to modulate adipose tissue thermogenic capacity.
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Chymkowitch lab @chymkowitchlab.bsky.social · 19/03/2026
Key findings include: · Transient TAK-981 exposure leads to robust and stable induction of beiging genes, including UCP1, and increased mitochondrial respiration. · Mechanistic insights reveal immediate chromatin and enhancer activity remodeling and mobilization of CEBP family members and PPARG.
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Chymkowitch lab @chymkowitchlab.bsky.social · 19/03/2026
We investigated how the SUMOylation pathway regulates adipocyte plasticity. We discovered that brief pharmacologic inhibition of SUMOylation primes human pre-adipocytes for stable de novo beige differentiation when combined with PPARG activation.
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Chymkowitch lab @chymkowitchlab.bsky.social · 19/03/2026
Excited to share that our latest research has been published in @narjournal.bsky.social Read the article here: academic.oup.com/nar/article/... Congratulations to Patrizia Nothnagel and many thanks to all people involved including Nolwenn Briand, Bjørn Steen Skålhegg and @amathelier.bsky.social.
academic.oup.com
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Chymkowitch lab @chymkowitchlab.bsky.social · 25/09/2025
Many thanks to the organisers, sponsors, and members of the poster award committee for this prize and the wonderful conference. The work is supported by The Research Council of Norway. @biovitenskap.bsky.social @embo.org @uio.no
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Chymkowitch lab @chymkowitchlab.bsky.social · 25/09/2025
🌟 Congratulations to my PhD student Patrizia Nothnagel! 🌟 Patrizia won the "SUMO" poster award at the 2025 EMBO workshop "SUMOylation: From Discovery to Translation" in La Grande-Motte, France. Her work has paid off, and I am proud of her.
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Chymkowitch lab @chymkowitchlab.bsky.social · 06/08/2025
Many thanks to @biovitenskap.bsky.social and the research council of Norway for supporting this study and @igbmc.bsky.social sequencing facility for processing our samples.
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Chymkowitch lab @chymkowitchlab.bsky.social · 06/08/2025
IRX3 buffers the SUMOylation to promote adipogenesis and block osteogenesis. IRX3 loss boosts SUMOylation, inhibits PPARγ, and pushes cells toward bone fate, which is reversible with SUMOylation inhibition. IRX3 is an epigenetic gatekeeper. #Epigenetics #Adipogenesis #ObesityRisk #SUMOylation
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Chymkowitch lab @chymkowitchlab.bsky.social · 06/08/2025
I am delighted to share a publication in @natcomms.nature.com. IRX3, linked to obesity via the FTO locus, influences fat vs bone cell fate. It is the result of a wonderful collaboration between S. Dankel, G. Mellgren @unibergen.bsky.social and my lab @biovitenskap.bsky.social 🍾 👉 rdcu.be/ezA5o
rdcu.be
IRX3 controls a SUMOylation-dependent differentiation switch in adipocyte precursor cells
Nature Communications - Here, the authors show that IRX3 is a transcriptional master regulator of multiple histone- and chromatin-remodeling enzymes and the SUMOylation pathway in adipocyte...
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Chymkowitch lab @chymkowitchlab.bsky.social · 12/05/2025
We are extending the application deadline for this post-doc position! Do not miss the opportunity to join an exciting project in a dynamic and collaborative research environment. @igbmc.bsky.social @pasteur.fr @univbordeaux.bsky.social @uio.no #epigenetics #cellfate #SUMOylation @ncmbm.bsky.social
jobbnorge.no
Postdoctoral Research Fellow in Molecular Biology and Epigenetics (279366) | University of Oslo
Job title: Postdoctoral Research Fellow in Molecular Biology and Epigenetics (279366), Employer: University of Oslo, Deadline: Thursday, May 15, 2025
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Chymkowitch lab @chymkowitchlab.bsky.social · 25/04/2025
Totipotent-like cells in early mouse embryos reorganize their genome via Z-DNA and Zscan4-driven interactions to form a “Z compartment” first supporting ZGA and later compartmentalisation to safeguard the totipotent-like state. Chromatin plasticity at its finest! www.biorxiv.org/content/10.1...
biorxiv.org
Z-DNA formation induces the totipotent-like state and primes Zscan4-dependent chromatin compartmentalization
A remarkable transition during murine development is the progression from the 1-cell embryo to the 2-cell stage, accompanied by the activation of a specific set of embryonic genes, epigenome reprogram...
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Chymkowitch lab @chymkowitchlab.bsky.social · 23/04/2025
Thank you @alexis-verger.cpesr.fr !! I could say the same about you 👍
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Chymkowitch lab @chymkowitchlab.bsky.social · 23/04/2025
For this project we collaborate with @amathelier.bsky.social @ncmbm.bsky.social
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Chymkowitch lab @chymkowitchlab.bsky.social · 23/04/2025
www.mn.uio.no/ibv/english/...
mn.uio.no
Transcriptional Regulation Of Cell Fate - Department of Biosciences
We investigate the mechanisms regulating chromatin and gene expression during cellular differentiation and cell cycle progression in yeast and mammals.
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Chymkowitch lab @chymkowitchlab.bsky.social · 23/04/2025
This is a 3-year, full-time position in an international research environment. This position is funded by the Research Council of Norway. 🗓 Start date: ASAP 📅 Deadline: May 15, 2025 Apply here: www.jobbnorge.no/en/available...
jobbnorge.no
Postdoctoral Research Fellow in Molecular Biology and Epigenetics (279366) | University of Oslo
Job title: Postdoctoral Research Fellow in Molecular Biology and Epigenetics (279366), Employer: University of Oslo, Deadline: Thursday, May 15, 2025
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Chymkowitch lab @chymkowitchlab.bsky.social · 23/04/2025
We’re Hiring! I am seeking a Pos-doc Researcher in Molecular Biology and Epigenetics. Join our team @biovitenskap.bsky.social @uio.no to explore how SUMOylation regulates epigenetic fate, gene expression, 3D-genome and chromatin during adipogenesis, with implications for obesity and cancer research.
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Chymkowitch lab @chymkowitchlab.bsky.social · 14/04/2025
This study is a very elegant characterisation of the epigenetic and transcriptional divergence between white and beige adipocytes. Very useful to those studying the epigenetic mechanisms supporting cellular reprogramming. www.biorxiv.org/content/10.1...
biorxiv.org
Multimodal epigenetic and enhancer network remodeling shape the transcriptional landscape of beige adipocytes
Epigenetic regulation is a key determinant of adipocyte fate and function, conferring phenotypic plasticity to adipose tissue in response to metabolic and thermal challenges. To understand the spatiot...
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PLOS Biology @plosbiology.org · 18/03/2025
Genome sequencing & single-cell transcriptomics continue to produce findings that challenge the idea that #cancer is purely a genetic disease. This Essay delves into #omics data that questions the somatic mutation theory & presents alternative theories based on GRNs & tissue fields.🧪 plos.io/3DRtAEW
A figure depicting the concept of cancer attractor states within Waddington's landscape, and how gene regulatory network dynamics influence these states. The figure shows how cancerous cells derive from those that have accidentally entered into unused attractor states that are usually unoccupied in developmental trajectories.
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Chymkowitch lab @chymkowitchlab.bsky.social · 06/03/2025
As TAK-981 is in clinical trial for cancer, these findings highlight the need to consider its potential metabolic effects. Nice collaboration between my group at @uio.no @biovitenskap.bsky.social, Antoine Martinez @ucauvergne.bsky.social #Adipogenesis #SUMOylation #Metabolism #InVivo #CancerTherapy
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Chymkowitch lab @chymkowitchlab.bsky.social · 06/03/2025
Our recent in vivo study reveals that inhibiting SUMOylation with TAK-981 disrupts fat accumulation, leading to impaired adipogenesis and increased immune cell infiltration in perigonadal white adipose tissue. www.tandfonline.com/doi/full/10....
tandfonline.com
Pharmacological inhibition of SUMOylation with TAK-981 mimics genetic HypoSUMOylation in murine perigonadal white adipose tissue
Post-translational modification by the small ubiquitin-like modifier (SUMO) is essential for cellular differentiation and homeostasis. Here, we investigate the role of SUMOylation in adipose tissue...
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Chymkowitch lab @chymkowitchlab.bsky.social · 22/01/2025
A second position will be soon advertised for molecular biologists. Stay tuned!
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Chymkowitch lab @chymkowitchlab.bsky.social · 22/01/2025
Applications are welcome here: www.jobbnorge.no/en/available...
jobbnorge.no
Postdoctoral Research Fellow in Computational Biology and Epigenetics (273869) | University of Oslo
Job title: Postdoctoral Research Fellow in Computational Biology and Epigenetics (273869), Employer: University of Oslo, Deadline: Friday, February 28, 2025
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Chymkowitch lab @chymkowitchlab.bsky.social · 22/01/2025
The project involves integration of ATAC-seq, ChIP-seq, CAGE and HiC experiments to reveal mechanisms that prevent epigenetic and transcriptional drifting during cellular reprogramming with a particular focus on the adipose tissue.
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Chymkowitch lab @chymkowitchlab.bsky.social · 22/01/2025
My group @biovitenskap.bsky.social is #hiring a Post-doc in bioinformatics and biostatistics to work on #epigenetic memory in stem cells and during cell reprogramming. The position is co-supervised by @amathelier.bsky.social from @nordicembl.bsky.social
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Chymkowitch lab @chymkowitchlab.bsky.social · 21/01/2025
Thanks for sharing the first of the two positions that we will propose in the next 6 months @biovitenskap.bsky.social Stay tuned!
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Chymkowitch lab @chymkowitchlab.bsky.social · 21/01/2025
Thanks @amathelier.bsky.social. The start of a great adventure 😀
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Department of Biosciences, University of Oslo @biovitenskap.bsky.social · 21/01/2025
As part of this initiative, two postdoctoral fellowships will soon be advertised. One focusing on Molecular and Cell Biology, and one focusing on bioinformatics and biostatistics. Stay tuned for more updates and details about these positions! @chymkowitchlab.bsky.social www.mn.uio.no/ibv/english/...
mn.uio.no
Funding to Research on Epigenetic memory - Department of Biosciences
Pierre Chymkowitch at the University of Oslo is awarded 12 million NOK by The Norwegian Research Council, to investigate how SUMOylation influences epigenetic stability and could prevent diseases like...
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Anthony Mathelier @amathelier.bsky.social · 20/01/2025
Oslo skeeps. We will host @michaelhoffman.bsky.social on Mon. Jan. 27th. Looking forward to his seminar about "Identifying transcription factor binding using open chromatin, transcriptome, and methylation data." You can also book a time to meet him. More info at www.mn.uio.no/bils/english...
mn.uio.no
Dr. Michael Hoffman - Bioinformatics in Life Science – BiLS
Dr. Michael Hoffman, Chair of the Computational Biology and Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, and Associate Professor at the Department of Medical ...
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Max Planck Institute of Immunobiology and Epigenetics @mpi-ie.bsky.social · 21/01/2025
Three more days to register and submit your abstract for the upcoming TriRhena Gene Regulation Club. #epigenetics
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Arnaud Krebs @arnaudkr.bsky.social · 15/01/2025
Single molecule approaches across the central dogma! Genomics, imaging and theory! Very excited to host the first edition of Gene regulation, one molecule at a time this July @embl.org! Great lineup and many abstract selected talks!
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Rosa Ritunnano @rritunnano.bsky.social · 20/12/2024
Instead of listing my publications, as the year draws to an end, I want to shine the spotlight on the commonplace assumption that productivity must always increase. Good research is disruptive and thinking time is central to high quality scholarship and necessary for disruptive research.
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Nature Portfolio @natureportfolio.nature.com · 22/12/2024
Many workplaces have parties or team meals to celebrate the end of the working year, but some show true appreciation by cultivating group traditions. Nature asked group leaders to explain these, and how they thank colleagues for their hard work. #AcademicSky
go.nature.com
How to thank your lab mates: eight ways to show gratitude at the end of year
Alongside secret Santas and seasonal parties, many laboratories develop traditions to show appreciation to colleagues — from sweets and mulled wine to quizzes and ice-skating trips.
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1000WomeninSTEM @1000womeninstem.bsky.social · 22/12/2024
6️⃣0️⃣ Marie Skłodowska-Curie (1867-1934) 🇵🇱🇫🇷 #womeninSTEM The most famous scientist in the world. 1st woman professor at Sorbonne, only woman to win the Nobel in 2 different fields. During WWI, she invented a mobile X-ray unit that could travel to the battlefront. www.nobelprize.org/womenwhochan...
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Anthony Mathelier @amathelier.bsky.social · 20/12/2024
Congratulations, Pierre @chymkowitchlab.bsky.social. It's a fantastic news indeed! I look forward to continuing to collaborate with you on this great project. Bioinformaticians/data scientists: stay tuned for an upcoming postdoc position to analyze cool multi-omics data supervised by Pierre and I!
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Chymkowitch lab @chymkowitchlab.bsky.social · 20/12/2024
Yes, this will be a fun collaboration.
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Anthony Mathelier @amathelier.bsky.social · 20/12/2024
Very exciting; I strongly recommend!
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Chymkowitch lab @chymkowitchlab.bsky.social · 20/12/2024
Thanks Alexis !
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Chymkowitch lab @chymkowitchlab.bsky.social · 20/12/2024
Excited for the journey ahead! 🌟
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Chymkowitch lab @chymkowitchlab.bsky.social · 20/12/2024
A sincere thank you to everyone who contributed to this achievement, including collaborators @uio.no — @amathelier.bsky.social, Jorrit Enserink, Philippe Collas, Nolwenn Briand, Kari Rygg and Magnar Bjørås — as well as Stéphanie Le Gras and Bernard Jost at IGBMC, BRIC and @univbordeaux.bsky.social
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Chymkowitch lab @chymkowitchlab.bsky.social · 20/12/2024
🎄 What a fantastic Christmas gift! Our #FRIPRO application on the regulation of epigenetic fate by #SUMOylation has been awarded 12MNOK by the Research Council of Norway!
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Chymkowitch lab @chymkowitchlab.bsky.social · 15/12/2024
Thousands of people have donated to rebuild Notre-Dame de Paris, including me. But there are hundreds of heritage sites that deserve our attention. Why not make small donations to support projects like this surprising pagoda in the heart of France? www.fondation-patrimoine.org/les-projets/...
fondation-patrimoine.org
Pagode du Petit Jonas à Ambazac
Aujourd'hui très délabrée, la pagode du Petit Jonas va faire l'objet d'une campagne de restauration globale, dans le cadre de la redynamisation d'une base de loisirs entreprise par la commune d'Ambaza...
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