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ching-hochang.bsky.social

@ching-hochang.bsky.social
91 followers 58 following 10 posts
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ching-hochang.bsky.social @ching-hochang.bsky.social · 15/10/2026
Thank you, Barbara.
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Reposted by @ching-hochang.bsky.social
Harmit Singh Malik @harmitmalik.bsky.social · 13/10/2026
Check out this very nice piece on our article by Viviane Callier: cen.acs.org/biological-c...
cen.acs.org
This arbiter protein keeps the balance between X and Y chromosomes
Protamine’s role in a sex-selection arms race may be why it evolves so quickly
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Reposted by @ching-hochang.bsky.social
Harmit Singh Malik @harmitmalik.bsky.social · 10/10/2026
Most animal species pack sperm DNA with protamines instead of histones. Protamines are essential for male fertility. They are among the fastest-evolving genes in animals. That makes little sense. We think we know why, in a new paper led by @ching-hochang.bsky.social. www.science.org/doi/10.1126/...
science.org
Rapid protamine evolution suppresses meiotic drive in Drosophila
Many animal species replace histones with protamines during spermatogenesis. Although essential for sperm function, protamines evolve rapidly for reasons that remain unknown. Using in vivo gene replac...
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Reposted by @ching-hochang.bsky.social
Pravrutha Raman @pravrutharaman.bsky.social · 08/10/2026
Now that we have moved coasts, I am thrilled to share that the ChromEvo (Raman) lab is officially open at UMass Boston 🎉 We ask how CHROMatin EVOlution leads to functional innovation and we are hiring at multiple levels. Read on and share with folks who maybe interested chromevoramanlab.github.io
The logo with a phylogenetic tree, a budding yeast, a fly and a nucleosome that has Raman lab Chrom Evo written in the middle
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ching-hochang.bsky.social @ching-hochang.bsky.social · 08/10/2026
Now, the next chapter! Our lab at the Institute of Molecular Biology, Academia Sinica in Taiwan, is fully up and running. We are actively recruiting passionate researchers at all levels to tackle bold ideas in cell biology, chromosome architecture, and evolution: sites.google.com/view/ecg-lab...
sites.google.com
ECG LAB
"The only constant in life is change." — Heraclitus Genetic conflicts — the good, the bad, and the ugly — shape our lives over time We aim to understand why even the most essential genes and chrom...
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ching-hochang.bsky.social @ching-hochang.bsky.social · 08/10/2026
I also want to remember the late Meng-Chao Yao. His wisdom, kindness, and unwavering encouragement during my postdoc years and faculty job searches meant a lot to me. I am deeply grateful for his mentorship.
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ching-hochang.bsky.social @ching-hochang.bsky.social · 08/10/2026
This work would not have been possible without incredible mentors and colleagues. Huge thanks to Harmit Malik, Amanda Larracuente, Yukiko Yamashita, Benjamin Loppin, Barbara Wakimoto, Steve Henikoff, Kami Ahmad and many people for invaluable feedback, insights, and discussions over the years.
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ching-hochang.bsky.social @ching-hochang.bsky.social · 08/10/2026
Thrilled to share that our paper is finally out in Science Advances! 🔗 www.science.org/doi/10.1126/... TL;DR: A Drosophila protamine acts as shields resolving conflict between X and Y chromosomes. Disruption unleashes meiotic drive that kills X-bearing sperm and skews progeny sex ratios. 🪰🧬ᯡ
science.org
Rapid protamine evolution suppresses meiotic drive in Drosophila
Many animal species replace histones with protamines during spermatogenesis. Although essential for sperm function, protamines evolve rapidly for reasons that remain unknown. Using in vivo gene replac...
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ching-hochang.bsky.social @ching-hochang.bsky.social · 08/10/2026
Research is full of uncertainty, but every once in a while, nature works out exactly as you hypothesized. In 2019, while finishing my PhD, I pitched a bold idea in an email to @harmitmalik.bsky.social (below). Seven years later, it feels surreal to see that hypothesis become empirical reality. 🧵👇
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ching-hochang.bsky.social @ching-hochang.bsky.social · 11/07/2025
Finally, a huge thank you to my mentors Chau-Ti Ting, Amanda Larracuente and @harmitmalik.bsky.social, collaborators, and friends for their support. Special credit to Harmit for the lab name and logo inspiration.
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ching-hochang.bsky.social @ching-hochang.bsky.social · 11/07/2025
We’re actively recruiting at all levels: RAs, MS students, PhD students, and postdocs. If you’re passionate about evolutionary biology and excited to explore how lives are shaped by genetic conflicts, we’d love to hear from you! sites.google.com/view/ecg-lab...
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ching-hochang.bsky.social @ching-hochang.bsky.social · 11/07/2025
At ECG, we aim to understand why even the most essential genes and chromosome structures evolve—using a combination of genetic, genomic, and cellular approaches. We’re driven by curiosity and open to creative thinking across disciplines.
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ching-hochang.bsky.social @ching-hochang.bsky.social · 11/07/2025
I’m thrilled to announce the launch of the Evolution of Chromosomes and Genomes (ECG) Lab at the Institute of Molecular Biology, Academia Sinica, Taiwan. Our lab website is now live—come check it out! sites.google.com/view/ecg-lab...
sites.google.com
ECG LAB
"The only constant in life is change." — Heraclitus Genetic conflicts — the good, the bad, and the ugly — shape our lives over time We aim to understand why even the most essential genes and chrom...
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