Mitochondrial DNA (mtDNA) mutations cause inherited disease, accumulate with age, and recur in tumors, yet their effects remain unresolved because existing models interrogate one engineered allele at ...

Mutations in the autophagy protein EPG5 cause multisystem disease, including neurodegeneration. This study shows that impaired mitophagy drives mitochondrial Ca2+ overload with permeability transition...

Mitochondrial DNA (mtDNA) encodes genes essential for oxidative phosphorylation. The m.3243A>G mutation causes severe disease, including myopathy, lactic acidosis and stroke-like episodes (MELAS) a...