iiinova — where your digital self keeps evolving

Reposted by Charles Breeze

Anthony Beckhouse @antobeck.bsky.social · 11/06/2026

7th Edition of the Illumina Epigenetics Day. Register for the 2 (short) days of presentations. Registration will enable on-demand viewing in APAC regions. (Can't please everyone all the time). tinyurl.com/EpiDay2026 #Epigenetics #EPIC #5Base #methylation #genomics #illumina

033

Reposted by Charles Breeze

Jacob Kresovich @jkresovich.bsky.social · 11/06/2026

Hey, I’m presenting my research at this with several much more successful scientists (like Dan Belsky, Charles Breeze, Charlotte Ling, and Jonathan Mill). Come check us out!

022

Reposted by Charles Breeze

bioRxivpreprint @biorxivpreprint.bsky.social · 23/12/2025

LDscore: a scalable, Python 3-powered web platform for LD score regression analysis www.biorxiv.org/content/10.64898/20…

021

Reposted by Charles Breeze

bioRxiv Genomics @biorxiv-genomic.bsky.social · 23/12/2025

LDscore: a scalable, Python 3-powered web platform for LD score regression analysis www.biorxiv.org/content/10.64898/20…

071

Charles Breeze @charlesbreeze.bsky.social · 24/12/2025

Fast and precise genetic correlation + heritability analysis is now at your fingertips. Kudos @mitchiela.bsky.social Check out our full preprint in @biorxiv! Webtool ldlink.nih.gov/ldscore GitHub github.com/CBIIT/ldsc/t... Preprint doi.org/10.64898/202... #Genomics #GWAS #LDLink #OpenScience

ldlink.nih.gov

LDlink | LDscore

020

Charles Breeze @charlesbreeze.bsky.social · 24/12/2025

We are excited to integrate LDscore into the @theNCI LDlink suite! By joining a platform with: - 33,000+ annual active users - 2,200+ citations We’re moving the field from "managing HPC environments" to scientific discovery.

120

Charles Breeze @charlesbreeze.bsky.social · 24/12/2025

LDscore covers population LD references across 10 diverse populations, including African Americans and Latinos/Admixed Americans.

110

Charles Breeze @charlesbreeze.bsky.social · 24/12/2025

🌍 Diversity matters! New, expanded population references: LDscore allows for precision population matching, which is crucial even within subcontinental ancestry groups (e.g., using FIN for FinnGen RA). This is critical for isolating true polygenic signals from population stratification.

110

Charles Breeze @charlesbreeze.bsky.social · 24/12/2025

Precision is a core priority. We benchmarked the new Python 3 engine against the original command-line implementation using real GWAS data. The results are identical: total h2, intercept, and ratio metrics match perfectly. Accessible yet rigorous analysis.

120

Charles Breeze @charlesbreeze.bsky.social · 24/12/2025

Our first goal was to simplify LDSC analysis. LDscore moves the heavy lifting to the cloud, allowing you to compute LD scores, calculate h2, and estimate genetic correlation with a few clicks through a clean, intuitive interface. No local installation required.

110

Charles Breeze @charlesbreeze.bsky.social · 24/12/2025

LDSC is a cornerstone of statistical genetics. To make LDSC more accessible for the next generation of GWAS, we made LDscore: A scalable, Python 3-powered cloud platform that brings LD score regression directly to your browser.

120

Charles Breeze @charlesbreeze.bsky.social · 24/12/2025

Our new preprint is out now! 🎉🎉🎉 Big news for everyone doing GWAS: We have updated LD score regression (LDSC) for the next generation of genomics.

121

Charles Breeze @charlesbreeze.bsky.social · 03/10/2025

What an incredible experience at #SSACB2025! Lots of amazing science (and wonderful scientists) spanning computational biology and cancer multi-omics research. Loved presenting my research on "Integrative analysis of cancer GWAS at scale." Let's keep pushing cancer research forward, together! #GWAS

Presentation on FORGE2, an integrative epigenomics method, at the 2025 NCI Spring School on Algorithmic Cancer Biology, at the National Institutes of Health, Bethesda MD

020

Reposted by Charles Breeze

POP-GEM Lab @popgemlab.bsky.social · 16/01/2025

🚀 New paper by @madhurbsingh.bsky.social on smoking & DNA methylation via twin-based MR using @ntrbiopsy.bsky.social data! Supervised by Mike Neale, @jennyvandongen.bsky.social, & Conor Dolan. Co-authors: @dlapato.bsky.social, @charlesbreeze.bsky.social. 🔗 doi.org/10.1007/s106...

035