Larger language models do not always perform better at fitness prediction. Hou et al. found that performance depends on whether model outputs match evolutionary patterns in homologs, which is best ach...

Protein language models are powerful computational tools for protein fitness prediction. The recent investigation into the relationship between model outputs and prediction accuracy reveals the scalin...

Predictive models for missense variant pathogenicity offer little functional interpretation for intrinsically disordered regions, since they rely on conservation and coevolution across homologous sequ...

Proteins perform their functions by folding amino acid sequences into dynamic structural ensembles.