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Channelomics

@channelomics.bsky.social
472 followers 76 following 213 posts

Our Twitter feed lives on via an IFTTT rule, but this seems a nicer place. Ion channel stuff, papers, jobs, Studentship and if you are still active at a rig; sympathy! Anyone that’s done electrophysiology knows it is the ”sharp” end of science.

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Channelomics @channelomics.bsky.social · 17/08/2026
If this is happening -feel free to ping for a boost…
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Channelomics @channelomics.bsky.social · 27/07/2026
Electrophysiology in nanoscale compartments rupress.org/jgp/article/... #IonChannels Interesting, but sorry $$$$$$
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Channelomics @channelomics.bsky.social · 15/07/2026
Evolution, hibernation, and inactivation of voltage-gated Na #ionchannels | Journal of General Physiology rupress.org/jgp/article/...
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Channelomics @channelomics.bsky.social · 15/07/2026
Model prokaryotic potassium channels: Predictive power and relevance to eukaryotic #ionchannels | Journal of General Physiology rupress.org/jgp/article/...
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Reposted by Channelomics
Journal of General Physiology @jgp.org · 06/07/2026
Differential regulation of β1-dependent voltage shifts and kinetic modulation by an extracellular glutamate in NaV1.6 VSDIV. New study by Maxime Lammens, Frank Bosmans et al. (Ghent University) rupress.org/jgp/article/... #IonChannels #Biophysics #MolecularPharmacology
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Reposted by Channelomics
Journal of General Physiology @jgp.org · 06/07/2026
📣 Call for Papers 📣 JGP welcomes submissions that focus on increasing our understanding of the role of voltage-gated sodium channels in the broad physiological and pathophysiological context. 👉 rupress.org/jgp/pages/ca... #IonChannels #CallForPapers #WSCC26
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Channelomics @channelomics.bsky.social · 15/07/2026
Piezo #ionchannels et al
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Reposted by Channelomics
Journal of General Physiology @jgp.org · 14/07/2026
Kinetic reconstruction of graded membrane excitability in #Paramecium. New tudy from Takashi Tominaga and Yoko Tominaga (Tokushima Bunri University): rupress.org/jgp/article/... #CellularPhysiology
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bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 14/07/2026
PV interneuron-targeted CRISPRa rescue of SCN1A haploinsufficiency in Dravet syndrome www.biorxiv.org/content/10.64898/20…
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Channelomics @channelomics.bsky.social · 08/07/2026
Full article: mTORC2-Nav1.2 #ionchannel signaling drives early hyperexcitability in Alzheimer’s disease mouse model www.tandfonline.com/doi/full/10....
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Channelomics @channelomics.bsky.social · 08/07/2026
Gating shift to an ohmic mode of TREK-1 #ionchannel induced by docosahexaenoic acid: Biophysical Journal www.cell.com/biophysj/ful...
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Channelomics @channelomics.bsky.social · 03/07/2026
PIEZO #ionchannel Mechanotransduction in the Cardiovascular System: Physiological Roles and Disease Implications - Cardiovascular Science www.sciepublish.com/article/pii/...
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Channelomics @channelomics.bsky.social · 02/07/2026
If only there had been some clue. Editorial Note: Terahertz Irradiation Promotes Angiogenesis in vitro by Enhancing Permeability of the Voltage-Gated Calcium #IonChannel | PLOS One journals.plos.org/plosone/arti...
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Channelomics @channelomics.bsky.social · 02/07/2026
Full article: Role of TRPV4 #Ionchannels in high glucose-induced neurotoxicity in a neuronal-like cell model www.tandfonline.com/doi/full/10....
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Channelomics @channelomics.bsky.social · 01/07/2026
Differential regulation of β1-dependent voltage shifts and kinetic modulation by an extracellular glutamate in NaV1.6 #IonChannels VSDIV Journal of General Physiology $$$$$$ rupress.org/jgp/article/...
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Channelomics @channelomics.bsky.social · 01/07/2026
Mechanistic insights into DCPIB inhibition of VRAC anion #IonChannels: Electrostatic control and binding plasticity $$$$$$$$ rupress.org/jgp/article/...
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Channelomics @channelomics.bsky.social · 30/06/2026
An epilepsy-associated KV3.1 potassium #ionchannel variant acts via dominant-positive effect | Journal of General Physiology rupress.org/jgp/article/...
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Channelomics @channelomics.bsky.social · 30/06/2026
Structure-function analysis of the lithium-ion selectivity of the voltage-gated sodium #ionchannel | Journal of General Physiology rupress.org/jgp/article/...
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Reposted by Channelomics
Journal of General Physiology @jgp.org · 29/06/2026
Maxime Lammens, Frank Bosmans et al. show how an auxiliary β1 subunit tunes the activity of the human Na+ channel NaV1.6, a key regulator of electrical signaling in neurons, linking channel structure to mechanisms that shape neuronal excitability. rupress.org/jgp/article/... #IonChannels
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Channelomics @channelomics.bsky.social · 29/06/2026
Missense mutation causes multiple defects in Nav1.4 #ionchannel gating and leads to an SCN4A-associated overlap phenotype | Journal of General Physiology rupress.org/jgp/article/...
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Channelomics @channelomics.bsky.social · 29/06/2026
Bladder under stress: Pathological and adaptive shifts in #ionchannel expression www.tandfonline.com/doi/full/10....
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Channelomics @channelomics.bsky.social · 26/06/2026
Full article: Role for TREK-1 #ionchannels as a polymodal sensor and regulator of cell activity www.tandfonline.com/doi/full/10....
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Channelomics @channelomics.bsky.social · 26/06/2026
Full article: Quantitative analysis of trafficking defects induced by heterozygous expression of hERG #ionchannel voltage sensor domain variants www.tandfonline.com/doi/full/10....
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Channelomics @channelomics.bsky.social · 25/06/2026
Calmodulinopathy variants impair CaV1.3 and CaV2.1 #IonChannel regulation | Journal of General Physiology $$$$$$ rupress.org/jgp/article/...
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Channelomics @channelomics.bsky.social · 24/06/2026
Cav3.2 T‐type calcium #Ionchannels in chronic pain: Structural insights, pharmacological advances and challenges in subtype selectivity - Lu - British Journal of Pharmacology bpspubs.onlinelibrary.wiley.com/doi/10.1111/...
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Channelomics @channelomics.bsky.social · 23/06/2026
Structural evidence that a lipid plug controls K2P6.1(TWIK-2) #IonChannel function | Nature Communications www.nature.com/articles/s41...
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Channelomics @channelomics.bsky.social · 23/06/2026
NMDA and glycine #IonChannel receptors provide dual presynaptic regulation on climbing fibre inputs to cerebellar Purkinje cells - Benton - 2026 - The Journal of Physiology physoc.onlinelibrary.wiley.com/doi/10.1113/...
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Reposted by Channelomics
Yamuna Krishnan @krishnanyamuna.bsky.social · 22/06/2026
Our paper is now online here: rdcu.be/fpILZ
rdcu.be
A ratiometric fluorescent reporter of mitochondrial sodium
Nature Chemical Biology - A ratiometric fluorescent probe that maps absolute mitochondrial Na+ at single-organelle resolution and works independently of membrane potential has now been developed....
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Channelomics @channelomics.bsky.social · 22/06/2026
Functional role of Nav1.8 channels in action potentials of mouse CGRP‐lineage dorsal root ganglion neurons - Osorno - The Journal of Physiology physoc.onlinelibrary.wiley.com/doi/10.1113/...
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Channelomics @channelomics.bsky.social · 22/06/2026
The endogenous cannabinoid system gates plasticity of tonic GABA #IonChannel inhibition - Colangeli - 2026 - The Journal of Physiology physoc.onlinelibrary.wiley.com/doi/10.1113/...
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Channelomics @channelomics.bsky.social · 19/06/2026
Thanks, yes we are aware of these - well done for digging them up 🚀
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Channelomics @channelomics.bsky.social · 19/06/2026
Will the real KATP please stand up? Kir6.2/SUR2A takes the stand in the tiring case of skeletal muscle fatigue | Journal of General Physiology rupress.org/jgp/article/...
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Channelomics @channelomics.bsky.social · 19/06/2026
Similarity of the ion occupations of K+ and Tl+ in the selectivity filter of a K+ #IonChannel, as verified by single-channel currents. Channels. www.tandfonline.com/doi/full/10....
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Channelomics @channelomics.bsky.social · 19/06/2026
Typo sorry “no inference on”
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Channelomics @channelomics.bsky.social · 19/06/2026
They use capsaicin (the spice from pepper) merely to test the function of TRPV1. There are preliminary studies testing “skin-applied” capsaicin for chronic pain, but it will cause pain itself, so don’t try it. Nothing about “taking capsaicin”,nothing about muscle function. Sorry again!
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Channelomics @channelomics.bsky.social · 19/06/2026
This paper offers no guidance on that. It is a very fundamental study of TRPV1 properties and interactions with different membrane types. May be one day, a treatment will emerge from studies like this, but there can be on inference on increasing decreasing cholesterol. Sorry!
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Channelomics @channelomics.bsky.social · 18/06/2026
Full article: Cholesterol inhibits capsaicin activation of the TRPV1 channel www.tandfonline.com/doi/full/10....
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Channelomics @channelomics.bsky.social · 18/06/2026
Mechanistic insights into Orai #IonChannel dynamics during pore opening. Channels. www.tandfonline.com/doi/full/10....
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Channelomics @channelomics.bsky.social · 17/06/2026
Selective loss of Cx40 and conduction abnormalities underlie enhanced atrial fibrillation susceptibility in a HFpEF model in male mice - Kawajiri - 2026 - Physiological Reports - Wiley Online Library physoc.onlinelibrary.wiley.com/doi/10.14814... #IonChannels
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Channelomics @channelomics.bsky.social · 17/06/2026
Temperature and intrinsic Ca2+ reshape TRPM4 #ionchannel pharmacology | Nature Structural & Molecular Biology www.nature.com/articles/s41...
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Channelomics @channelomics.bsky.social · 16/06/2026
Pharmaceutical agents targeting KATP #ionchannel modulate sweet taste sensitivity in mice www.sciencedirect.com/science/arti... #ionchannels
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Channelomics @channelomics.bsky.social · 16/06/2026
The AMPA receptor #IonChannel life cycle: assembly, regulation and synaptic diversity | Nature Reviews Neuroscience $$$$$ www.nature.com/articles/s41...
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Rockefeller University Press @rupress.org · 15/06/2026
In @jgp.org, Rainbow & Barrett-Jolley discuss Scala et al. (rupress.org/jgp/article/...), who demonstrated that Kir6.2/SUR2-containing KATP potassium #IonChannels are the functionally relevant isoform that modulate contractile behavior of fast-twitch muscle during fatigue rupress.org/jgp/article/...
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valebodi.bsky.social @valebodi.bsky.social · 08/06/2026
for hundreds of thousands of Australians living with the debilitating illness Peer-Reviewed Publication GRIFFITH UNIVERSITY 🇦🇺 www.frontiersin.org/journals/med... #ME/CFS #TRPM3 #IonChannel
frontiersin.org
Frontiers | Large-scale investigation confirms TRPM3 ion channel dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
IntroductionMyalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a chronic disease hallmarked by multiple systemic symptoms, such as neurocognitive...
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Matthia Karreman @matthiakarreman.bsky.social · 13/05/2026
Mathematical modelling shows that non-neuronal cells can also produce stable Ca²⁺ oscillations under the right conditions. Analyzing the #ionchannel transcriptome, we identified gap junctions as specifically expressed in brain metastases. (5/12)
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Channelomics @channelomics.bsky.social · 15/06/2026
Sorry late posting this. From a few months ago.
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Journal of General Physiology @jgp.org · 27/05/2026
Subunit composition of the KATP channels that modulate contractility of skeletal muscle during fatigue. New study from Rosa Scala, Yuezhou Chen, Colin G. Nichols @colinnicholslab.bsky.social and colleagues @washumedicine.bsky.social: rupress.org/jgp/article/... #SkeletalMuscle #IonChannels
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Channelomics @channelomics.bsky.social · 15/06/2026
A kinetic trap mechanism underlies hHv1 #IonChannel inhibition by NZ-58 | Journal of General Physiology $$$$$ rupress.org/jgp/article/...
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Channelomics @channelomics.bsky.social · 14/06/2026
Functional screen for subtype specificity of voltage sensor–targeted Kv7 potentiators - Kanyo - British Journal of Pharmacology bpspubs.onlinelibrary.wiley.com/doi/10.1111/...
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Channelomics @channelomics.bsky.social · 14/06/2026
GPR35 modulates NaV1.9 #IonChannels in sensory neurons. Cromolyn disodium directly activates GPR35, but zaprinast and sildenafil also require GPR35, together shaping NaV1.9 gating and neuronal excitability. bpspubs.onlinelibrary.wiley.com/doi/10.1111/...
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