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Reposted by Abhishek Chandra PhD, MS

BMAS @bma-society.bsky.social · 20/03/2026

Paper of the month March 2026 Congratulations to the Sheller lab. NEW PUBLICATION: Zhang X, …, Scheller EL. A catecholamine-independent pathway controlling adaptive adipocyte lipolysis. Nat Metab. 2026 Jan;8(1):96-115. PMID: 41507664; PMCID: PMC12855016.

Paper of the month
March 2026

NEW PUBLICATION: Zhang X, …, Scheller EL. A catecholamine-independent pathway controlling adaptive adipocyte lipolysis. Nat Metab. 2026 Jan;8(1):96-115. PMID: 41507664; PMCID: PMC12855016.

Paper Highlight

Constitutive bone marrow adipose tissue (cBMAT) is largely resistant to conventional lipolytic stimuli, including acute fasting, caloric restriction, exercise, β-adrenergic agonists, and cold exposure. However, cBMAT can be depleted under extreme metabolic stress, such as severe anorexia, late stages of starvation, or pathological conditions associated with severe wasting and cachexia.
In a recent study, Zhang et al. identified a novel mouse model in which chronic (9-day) intracerebroventricular (ICV) leptin infusion mimics the end-stage depletion of BMAT. Surprisingly, this catabolic process appears to be independent of local peripheral nerves, sympathetic nervous system (SNS) signaling, or catecholamines. Instead, cBMAT depletion is associated with systemic hypoinsulinemia and hypoglycemia and is mediated by adipose triglyceride lipase (ATGL)–dependent lipolysis. Furthermore, the balance between the lipolytic inhibitor G0S2 and ATGL appears to regulate the lipolytic resistance of cBMAT.

Key findings (Description Up to 150 words) : I
ICV leptin infusion rapidly depletes cBMAT independent of reduced food intake.
ICV leptin–induced cBMAT depletion is not mediated by peripheral nerves, the SNS, or catecholamines.
Hypoinsulinemia and hypoglycemia contribute to cBMAT catabolism following ICV leptin treatment.
ICV leptin activates lipolysis in an ATGL-dependent manner.
The ratio of the lipolytic inhibitor G0S2 to ATGL is associated with the lipolytic resistance of cBMAT under baseline conditions, during aging, and after ICV leptin treatment.

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Reposted by Abhishek Chandra PhD, MS

BMAS @bma-society.bsky.social · 01/02/2026

Our January BMAS Paper of the Month shows- Proinflammatory and proangiogenic signaling, macrophage polarization, osteoclastogenesis, and BMAT expansion all converge to shape a complex, degradation-dependent marrow landscape. Previous Papers of the Month: bma-society.org/paper-of-the...

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Reposted by Abhishek Chandra PhD, MS

BMAS @bma-society.bsky.social · 30/12/2025

New BMAS Paper of the Month (Dec 2025) 🦴 from @lingqin6.bsky.social A must-read for bone researchers! 🔗 BMAS feature + article link: bma-society.org/paper-of-the... 📚 PoTM archive: bma-society.org/paper-of-the...

bma-society.org

Paper of the Month (BMAS) -

Each month, a recently published paper is selected for by the Scierntific Board of the to be spotlighted as out Paper of the Month.

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Reposted by Abhishek Chandra PhD, MS

BMAS @bma-society.bsky.social · 30/12/2025

Bone marrow adipogenic lineage key for Bone Resorption from @lingqin6.bsky.social ✔️ MALPs, not osteocytes, are the dominant RANKL source in adult marrow ✔️ RANKL deletion in MALPs suppresses osteoclasts ✔️ MALP-derived RANKL drives OVX-induced bone loss yet is dispensable for OVX marrow adiposity

bma-society.org

Paper of the Month (BMAS) -

Each month, a recently published paper is selected for by the Scierntific Board of the to be spotlighted as out Paper of the Month.

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Reposted by Abhishek Chandra PhD, MS

BMAS @bma-society.bsky.social · 30/12/2025

New BMAS Paper of the Month (Dec 2025) 🦴 from @lingqin6.bsky.social Lu et al., Bone marrow adipogenic lineage precursors are the major regulator of bone resorption in adult mice (Bone Research,2025) A must-read for bone researchers! 🔗 BMAS feature + article link: bma-society.org/paper-of-the...

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Reposted by Abhishek Chandra PhD, MS

BMAS @bma-society.bsky.social · 24/09/2025

🚨 Day 1: #BMAS2025 Join us today for outstanding invited lectures and engaging discussions. Hear from BMAS Society presidents Bram van der Eerden and other experts 🇳🇱🇩🇪🇺🇸🇨🇭on bone marrow microenvironment specialization, cutting-edge techniques for BMAT investigation, and grant-writing tips. #bone

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Abhishek Chandra PhD, MS @chandra-lab.bsky.social · 20/06/2025

Thank you @nmdcunha.bsky.social for hosting me for the CARAT lecture at University of Canberra. It was a pleasure interacting with you and your team.

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Abhishek Chandra PhD, MS @chandra-lab.bsky.social · 13/06/2025

#ANZSGM 2025 , Sydney Beautiful talk by Dr. Richard Lindley on stroke management with aging

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Reposted by Abhishek Chandra PhD, MS

BMAS @bma-society.bsky.social · 14/05/2025

📢 BMAS Paper of the Month - May 2025 🧬 "KIAA1199 (CEMIP) regulates adipogenesis and whole-body energy metabolism" by Chen et al., published in Bone Research. KIAA1199 as a key player in understanding bone-fat crosstalk! 👏 Congrats to @kmeblab.bsky.social & Moustapha Kassem! 📖 lnkd.in/eQKBDAU5

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Reposted by Abhishek Chandra PhD, MS

BMAS @bma-society.bsky.social · 19/05/2025

The International Bone Marrow Adiposity Society (BMAS) invites you to our 7th BMAS Webinar, featuring Dr. Clifford J. Rosen, MD., who currently oversees the Rosen Musculoskeletal Laboratory #RosenLab at the Main Health Institute for Research, USA. The registration link will come soon. Stay tuned!

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Reposted by Abhishek Chandra PhD, MS

BMAS @bma-society.bsky.social · 30/04/2025

Announcing the @BMA_Society Paper of the Month for April 2025 ! Published in @OACJournal, this study identifies a previously unrecognized role of #BMAT #lipolysis in the sub-chondral neo-osteogenesis associated with hand #osteoarthritis.

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Reposted by Abhishek Chandra PhD, MS

BMAS @bma-society.bsky.social · 30/04/2025

Using histological and biochemical analyses, this new work by Mauro Maniglio, @LeaLoisay, Diego de Haro, Alexander Antoniadis, Thomas Hügle and @OA_Lab_CHUV from @RheumaLab_CHUV sheds light on a previously overlooked role of BMAT in osteoarthritis. (Link: www.oarsijournal.com/article/S106...

oarsijournal.com

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Reposted by Abhishek Chandra PhD, MS

BMAS @bma-society.bsky.social · 31/03/2025

Post 2: Register at: umn-private.zoom.us/meeting/regi... This seminar will discuss the regulation of both regulated and constitutive #BMAT within the context of all #adipose tissues, and how this regulatory system evolves in states such as end stage starvation and cachexia.

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Reposted by Abhishek Chandra PhD, MS

BMAS @bma-society.bsky.social · 31/03/2025

Post 1: Exciting news! The 6th @BMA_Society Webinar "Neural Regulation of Marrow Adipose Tissue is coming up on April 14, 2025 at 11 AM EDT / 5PM CEST featuring Dr. Erica Scheller (@schellerlab) from @wustlcrm @WashU_MRC and Moderated by Thomas Ambrosi and @LingQin6

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Reposted by Abhishek Chandra PhD, MS

BMAS @bma-society.bsky.social · 31/03/2025

@bma-society.bsky.social The International BMAS is proud to highlight -Paper of the Month (March, 2025) -published in JBMR Plus! This study explores how a high-protein diet under caloric restriction affects muscle, bone, and marrow adipose tissue (MAT). doi.org/10.1093/jbmr...

doi.org

Low-calorie and high-protein diet has diverse impacts on the muscle, bone, and bone marrow adipose tissues

Abstract. The present study was designed to evaluate the influence of a high-protein diet under conditions of calorie restriction (CR) in the muscle, adipo

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Reposted by Abhishek Chandra PhD, MS

BMAS @bma-society.bsky.social · 06/03/2025

🚨 @bma-society.bsky.social is excited to announce the 3rd BMAS Summer School 2025, held virtually from 24-26 September! Registration opens March 15th. This event is for graduate students, postdocs and young researchers interested in bone marrow adiposity. For more details visit our webpage 🗣️🖥️.

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Reposted by Abhishek Chandra PhD, MS

BMAS @bma-society.bsky.social · 27/02/2025

📢 @bma-society.bsky.social Paper of the Month (February 2025): "Deep learning and genome-wide association meta-analyses of bone marrow adiposity" in @naturecomms.bsky.social This is a groundbreaking study! @naturecomms.bsky.social @BMATscientists from @EdinUniCVS and co-authors.

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Reposted by Abhishek Chandra PhD, MS

Osteoporosis NL @osteoporosis-nl.bsky.social · 06/02/2025

Combined Romosozumab and Raloxifene treatment targets impaired bone quality in a male murine model of diabetic kidney disease. Rachel Kohler et al. Bone 28 Jan 2025 tinyurl.com/r2nw3t46 …Romo increased whole-bone strength and RAL improved tissue-level mechanical properties

tinyurl.com

Redirecting

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Reposted by Abhishek Chandra PhD, MS

Furqan Shah @shahfa.bsky.social · 01/02/2025

🔥Hot off the press🔥 "Revisiting the physical and chemical nature of the mineral component of bone" 🦴🔬 doi.org/10.1016/j.ac... 🧪 #bone #biomaterials #apatite #mineral #biomineralization #collagen #calcium #phosphate #hydroxyapatite #osteocyte #biology #medicine #osteology #osteoarchaeology

The physico-chemical characteristics of bone mineral remain heavily debated. On the nanoscale, bone mineral resides both inside and outside the collagen fibril as distinct compartments fused together into a cohesive continuum. On the micrometre level, larger aggregates are arranged in a staggered pattern described as crossfibrillar tessellation. Unlike geological and synthetic hydroxy(l)apatite, bone mineral is a unique form of apatite deficient in calcium and hydroxyl ions with distinctive carbonate and acid phosphate substitutions (CHAp), together with a minor contribution of amorphous calcium phosphate as a surface layer around a crystalline core of CHAp. In mammalian bone, an amorphous solid phase has not been observed, though an age-dependent shift in the amorphous-to-crystalline character is observed. Although octacalcium phosphate has been postulated as a bone mineral precursor, there is inconsistent evidence of calcium phosphate phases other than CHAp in the extracellular matrix. In association with micropetrosis, magnesium whitlockite is occasionally detected, indicating pathological calcification rather than a true extracellular matrix component. Therefore, the terms ‘biomimetic’ or ‘bone-like’ should be used cautiously in descriptions of synthetic biomaterials. The practice of reporting the calcium-to-phosphorus ratio (Ca/P) as proxy for bone mineral maturity oversimplifies the chemistry since both Ca2+ and PO43- ions are partially substituted. Moreover, non-mineral sources of phosphorus are ignored. Alternative compositional metrics should be considered. In the context of bone tissue and bone mineral, the term ‘mature’ must be used carefully, with clear criteria that consider both compositional and structural parameters and the potential impact on mechanical properties.

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Reposted by Abhishek Chandra PhD, MS

JAMA @jama.com · 11/02/2025

Osteoporosis is a disorder of decreased bone density that increases the risk of fractures, especially after a fall. This JAMA Patient Page describes osteoporosis and the USPSTF recommendations for screening for #osteoporosis. ja.ma/4aVmn2C #MedSky

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Reposted by Abhishek Chandra PhD, MS

BMAS @bma-society.bsky.social · 06/02/2025

Hi, BlueSky! We´re the International Bone Marrow Adiposity Society – The premier #international research society focusing on the role of bone marrow #adipose tissue in #health and disease. Learn more: bma-society.org

bma-society.org

BMAS - Shared passion for bone marrow adipose tissue

We are the sole international society focusing on research of bone marrow adipose tissue (BMAT) in health and disease (musculoskeletal, metabolic, cancer)

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Reposted by Abhishek Chandra PhD, MS

David Achudhan @realcatalyst.bsky.social · 06/02/2025

#ORS2025 🎉 Excited to present our Chandra Lab @chandra-lab.bsky.social research on Radiation-induced P21+ Senescent Myeloid Cells & Neutrophils in Bone Loss in Phoenix! 📅 Feb 8, 2025 | 9:25-9:35 AM 📌 Session 004: Bone Health & Healing Join us! #BoneResearch #RadiationBiology #ChandraLab

ors.org

2025 Annual Meeting - ORS

Join us for the ORS 2025 Annual Meeting, taking place February 7-11, 2025 in Phoenix, Arizona at the Phoenix Convention Center. The meeting will bring the orthopaedic community together for five days ...

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Reposted by Abhishek Chandra PhD, MS

Jason C. Marvin, Ph.D. (he/they) 🏳️‍🌈 @jasoncmarvin.bsky.social · 02/02/2025

Hey #ORS2025 Attendees, The last two weeks have shown that we as scientists need to urgently join the conversation given the devastating disruptions to biomedical research. Interested in learning more? Join our advocacy session this Saturday, Feb. 8 from 12:45-1:45 PM. @orssociety.bsky.social

A flyer for this session entitled "Evidence-Based Advocacy to Inform Science Policy Decisions: An Orthopaedics Case Study."

The session will be held on Saturday, February 8th, 2025 from 12:45-1:45 PM MT (Room North 222). Hosted By The ORS Public Outreach Committee.

The featured speakers are Drs. Mary Bouxsein (Harvard Medical School) and Jennifer Westendorf (Mayo Clinic). Organizers are Drs. Jason Marvin (Harvard Medical School), Erin Mannen (Boise State Univeristy), and Sade Clayton (Washington University in St. Louis) and Bonnie Walton (Vanderbilt).

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Abhishek Chandra PhD, MS @chandra-lab.bsky.social · 28/01/2025

Telomere dysfunction-induced foci : a key hallmark of cellular senescence. Red- telomere, green - gamma H2AX and yellow is the TIF foci

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