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BMAS @bma-society.bsky.social · 20/03/2026

Paper of the month March 2026 Congratulations to the Sheller lab. NEW PUBLICATION: Zhang X, …, Scheller EL. A catecholamine-independent pathway controlling adaptive adipocyte lipolysis. Nat Metab. 2026 Jan;8(1):96-115. PMID: 41507664; PMCID: PMC12855016.

Paper of the month
March 2026

NEW PUBLICATION: Zhang X, …, Scheller EL. A catecholamine-independent pathway controlling adaptive adipocyte lipolysis. Nat Metab. 2026 Jan;8(1):96-115. PMID: 41507664; PMCID: PMC12855016.

Paper Highlight

Constitutive bone marrow adipose tissue (cBMAT) is largely resistant to conventional lipolytic stimuli, including acute fasting, caloric restriction, exercise, β-adrenergic agonists, and cold exposure. However, cBMAT can be depleted under extreme metabolic stress, such as severe anorexia, late stages of starvation, or pathological conditions associated with severe wasting and cachexia.
In a recent study, Zhang et al. identified a novel mouse model in which chronic (9-day) intracerebroventricular (ICV) leptin infusion mimics the end-stage depletion of BMAT. Surprisingly, this catabolic process appears to be independent of local peripheral nerves, sympathetic nervous system (SNS) signaling, or catecholamines. Instead, cBMAT depletion is associated with systemic hypoinsulinemia and hypoglycemia and is mediated by adipose triglyceride lipase (ATGL)–dependent lipolysis. Furthermore, the balance between the lipolytic inhibitor G0S2 and ATGL appears to regulate the lipolytic resistance of cBMAT.

Key findings (Description Up to 150 words) : I
ICV leptin infusion rapidly depletes cBMAT independent of reduced food intake.
ICV leptin–induced cBMAT depletion is not mediated by peripheral nerves, the SNS, or catecholamines.
Hypoinsulinemia and hypoglycemia contribute to cBMAT catabolism following ICV leptin treatment.
ICV leptin activates lipolysis in an ATGL-dependent manner.
The ratio of the lipolytic inhibitor G0S2 to ATGL is associated with the lipolytic resistance of cBMAT under baseline conditions, during aging, and after ICV leptin treatment.

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BMAS @bma-society.bsky.social · 02/02/2026

Feb, 2026 Today is World Cancer Day 2026. At The International Bone Marrow Adiposity Society, we support basic and clinical research that unravels the role of bone marrow adipose tissue (BMAT) across a wide spectrum of cancers, from hematological malignancies to solid tumors. #BMAS #BMAsociety

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BMAS @bma-society.bsky.social · 02/02/2026

FEB, 2026 Today is World Cancer Day 2026 - a global reminder of the urgency to prevent, detect, and treat cancer. Join us in promoting innovative science that strengthens prevention, improves early detection, and advances cancer treatment. #BMAS #BMAsociety #bonemarrowadipose #bonemarrowadiposity

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BMAS @bma-society.bsky.social · 01/02/2026

Our January BMAS Paper of the Month shows- Proinflammatory and proangiogenic signaling, macrophage polarization, osteoclastogenesis, and BMAT expansion all converge to shape a complex, degradation-dependent marrow landscape. Previous Papers of the Month: bma-society.org/paper-of-the...

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BMAS @bma-society.bsky.social · 01/02/2026

Our January BMAS Paper of the Month shows that immunomodulatory Mg screws promote osteogenesis at the interface and drive a previously unrecognized increase in peri-implant bone marrow adiposity, especially with high-purity Mg and its faster degradation. 🔗 BMAS: bma-society.org/paper-of-the...

Proinflammatory and proangiogenic signaling, macrophage polarization, osteoclastogenesis, and BMAT expansion all converge to shape a complex, degradation-dependent marrow landscape.

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BMAS @bma-society.bsky.social · 26/01/2026

📣 Save the date! The 9th International Meeting on Bone Marrow Adiposity will take place 10–11 Sept 2026 in Edinburgh, Scotland 🏴󠁧󠁢󠁳󠁣󠁴󠁿 Two days of science, discussion, and exchange. More details coming soon. #BoneMarrowAdiposity #MedicalResearch #TranslationalResearch #BoneHealth #Edinburgh

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BMAS @bma-society.bsky.social · 30/12/2025

New BMAS Paper of the Month (Dec 2025) 🦴 from @lingqin6.bsky.social A must-read for bone researchers! 🔗 BMAS feature + article link: bma-society.org/paper-of-the... 📚 PoTM archive: bma-society.org/paper-of-the...

bma-society.org

Paper of the Month (BMAS) -

Each month, a recently published paper is selected for by the Scierntific Board of the to be spotlighted as out Paper of the Month.

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BMAS @bma-society.bsky.social · 30/12/2025

Bone marrow adipogenic lineage key for Bone Resorption from @lingqin6.bsky.social ✔️ MALPs, not osteocytes, are the dominant RANKL source in adult marrow ✔️ RANKL deletion in MALPs suppresses osteoclasts ✔️ MALP-derived RANKL drives OVX-induced bone loss yet is dispensable for OVX marrow adiposity

bma-society.org

Paper of the Month (BMAS) -

Each month, a recently published paper is selected for by the Scierntific Board of the to be spotlighted as out Paper of the Month.

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BMAS @bma-society.bsky.social · 30/12/2025

New BMAS Paper of the Month (Dec 2025) 🦴 from @lingqin6.bsky.social Lu et al., Bone marrow adipogenic lineage precursors are the major regulator of bone resorption in adult mice (Bone Research,2025) A must-read for bone researchers! 🔗 BMAS feature + article link: bma-society.org/paper-of-the...

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BMAS @bma-society.bsky.social · 19/11/2025

Sub-post 2: 🩺 CLINICAL GAME-CHANGER: This positions BMAT as: Biomarker for disease risk assessment Potential therapeutic target Tool for precision medicine The message is clear: analyze BMAT at MULTIPLE sites or miss critical pathophysiology! bma-society.org/paper-of-the... #BMAT

bma-society.org

Paper of the Month Archive - (BMAS)

Past issues of the Paper of the Month selected by the Scientific Board of the Bone Marrow Adiposity Society

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BMAS @bma-society.bsky.social · 19/11/2025

FINDINGS: BMAT linked to osteoporosis, fractures, T2D, CVD, cancers PLOT TWIST: Type 2 diabetes correlates: ✅ Positive with spinal BMAT ❌ Negative with femoral BMAT Mendelian randomization confirms CAUSAL link to osteoporosis Site-specific biology = site-specific disease!

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BMAS @bma-society.bsky.social · 19/11/2025

🚨 November #PaperOfTheMonth is MASSIVE! 🚨 Xu et al. analyzed 48,000+ UK Biobank participants with MRI to reveal bone marrow adiposity's links to 47 DISEASES across 12 categories The twist? Location matters MORE than we thought 🦴 This changes EVERYTHING about BMAT biology

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BMAS @bma-society.bsky.social · 10/11/2025

🎙️ Happening TODAY! Join us for the 9th Webinar featuring Dr. William Cawthorn. He’ll present “Insights from recent large-scale analyses of bone marrow adiposity in the UK Biobank” uncovering how #BMAT is emerging as a clinically relevant and genetically tractable target for future research.

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BMAS @bma-society.bsky.social · 20/10/2025

Today is the #WorldOsteoporosisDay 🦴 Raise awareness about osteoporosis and bone health 🗣️🌏. The BMAS is dedicated to advancing both basic and clinical research to better understand osteoporosis and improve patient outcomes. Join us in supporting innovative science! #BoneHealth #Osteoporosis #Life

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BMAS @bma-society.bsky.social · 15/10/2025

Sub-post 2 🩺 CLINICAL IMPACT: This could revolutionize how we approach: Hip replacement outcomes Bone healing strategies Hematopoietic recovery post-surgery Personalized orthopedic medicine Props to @drenka-trivanovic-8ab21435 & team! 👏 📖 Read the full study at bma-society.org/paper-of-the...

bma-society.org

Paper of the Month (BMAS) -

Each month, a recently published paper is selected for by the Scierntific Board of the to be spotlighted as out Paper of the Month.

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BMAS @bma-society.bsky.social · 15/10/2025

Sub-post 1 Femoral BMAT: Higher saturated fats, MORE hematopoietic stem cells Acetabular BMAT: Different lipid profile, FEWER blood-forming cells Same patient, different skeleton location = different biology This work sheds new light on BMAT physiology! www.mdpi.com/2218-1989/15...

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BMAS @bma-society.bsky.social · 15/10/2025

#PaperOfTheMonth reveals that location matters MORE than we thought! New research by @drenka.bsky.social et al. shows bone marrow adipose tissue (BMAT) has completely different "personalities" depending on where it sits in your skeleton 🦴 Femoral BMAT ≠ Acetabular BMAT in #osteoarthritis patients.

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BMAS @bma-society.bsky.social · 26/09/2025

🚨 Day 3: #BMAS2025 Today, let´s learn about BMAT metabolism, nutritional interventions, BMAT modeling, clinical imaging, and group establishment. @ifmrs.bsky.social @elsevierconnect.bsky.social @biologists.bsky.social

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BMAS @bma-society.bsky.social · 25/09/2025

🌍✨ The BMAS Summer School 2025 is live! Right now, participants from across the globe have gathered for this year’s program. We are proud to welcome participants from 17 countries, all bringing their passion and expertise to advance bone marrow adipose tissue research💡🔬 #BMAS2025

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BMAS @bma-society.bsky.social · 25/09/2025

🚨 Day 2: #BMAS2025 Today let's explore interactions between BMAT, hematopoiesis, and cancers, BMAT mechanosensitivity, and mitochondrial function. Join our vibrant career session covering Industry vs. Academia. @ifmrs.bsky.social @elsevierconnect.bsky.social @biologists.bsky.social

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BMAS @bma-society.bsky.social · 24/09/2025

🚨 Day 1: #BMAS2025 Join us today for outstanding invited lectures and engaging discussions. Hear from BMAS Society presidents Bram van der Eerden and other experts 🇳🇱🇩🇪🇺🇸🇨🇭on bone marrow microenvironment specialization, cutting-edge techniques for BMAT investigation, and grant-writing tips. #bone

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BMAS @bma-society.bsky.social · 05/09/2025

⏳ 5 days left to register for BMAS Summer School 2025! Don’t miss your chance to join this exciting virtual event filled with insightful sessions and great networking opportunities. Secure your spot today and be part of an inspiring learning experience! #BMAS2025

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BMAS @bma-society.bsky.social · 25/08/2025

We are thrilled to announce that our Biobanking Working Group has just published a review article in Bone Reports, @elsevierconnect.bsky.social 🎉

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BMAS @bma-society.bsky.social · 09/07/2025

Save the date!! The next @bma-society.bsky.social Webinar featuring @AttaneC from IPBS Toulouse will be on 29Sep2025, 10AM EST/4pm CET. Dr. Attané will discuss "Fat and fate: How Bone Marrow Adipocytes shape cancer progression". Synopsis, bio, and registration info posted at...

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BMAS @bma-society.bsky.social · 04/07/2025

🚨BMAS Summer School 2025 🌴 The abstract submission deadline has been extended to July 11! Just a few days left ⏳ Don´t miss your chance to be part of this virtual event! 💻🦴 Submit now 👉 bma-society.org/bmas-summer-... #BMAS2025 #BoneResearch #VirtualEvent #Science

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BMAS @bma-society.bsky.social · 23/06/2025

⏳ Missed the deadline? Good news! The BMAS Summer School 2025 registration is extended until July 11! 📅 When? September 24–26, 2025 💻 Where? Online (join from anywhere!) 🔬 What? A unique opportunity to dive into the fascinating world of bone marrow adipose tissue (BMAT) with leading experts.

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BMAS @bma-society.bsky.social · 20/06/2025

Unlike traditional #TZD, MSDC-0602K's unique metabolic signature in #BMSC = improved #InsulinResistance AND healthier bones! Read the full study at: doi.org/10.1016/j.me...

doi.org

Redirecting

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BMAS @bma-society.bsky.social · 20/06/2025

MSDC-0602K, a next-generation #TZD, rewires metabolism in bone marrow stem cells - promoting #BoneFormation while reducing #BMAT accumulation. This tissue-specific approach opens new doors for safer #Diabetes treatments! The paper is archived at bma-society.org/paper-of-the...

bma-society.org

Paper of the Month Archive - (BMAS)

Past issues of the Paper of the Month selected by the Scientific Board of the Bone Marrow Adiposity Society

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BMAS @bma-society.bsky.social · 20/06/2025

The @bma-society.bsky.social is excited to highlight our June 2025 #POTM! New research in Metabolism by @ondrej-kuda.bsky.social @CzechAcademy may be a #GameChanger for treating #Diabetes & preserving bone health. Using spatial fluxomics, they reveal how a new #TZD reprograms BMSC metabolism...

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Reposted by BMAS

BMAS @bma-society.bsky.social · 18/06/2025

🚨 The deadline is approaching! ⏰ Share and submit to join us for the event 🗣️

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BMAS @bma-society.bsky.social · 18/06/2025

🚨 The deadline is approaching! ⏰ Share and submit to join us for the event 🗣️

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BMAS @bma-society.bsky.social · 16/06/2025

🚨 Join us for the 3rd @BMAS Summer School 2025, a virtual event from Sept 24–26! Dive into cutting-edge talks, connect globally, and advance research in #BoneMarrowAdiposity 🗺️. ⏳ Deadline to apply: June 20! Submit your abstract + motivation letter now! 🧬

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BMAS @bma-society.bsky.social · 19/05/2025

The International Bone Marrow Adiposity Society (BMAS) invites you to our 7th BMAS Webinar, featuring Dr. Clifford J. Rosen, MD., who currently oversees the Rosen Musculoskeletal Laboratory #RosenLab at the Main Health Institute for Research, USA. The registration link will come soon. Stay tuned!

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BMAS @bma-society.bsky.social · 14/05/2025

📢 BMAS Paper of the Month - May 2025 🧬 "KIAA1199 (CEMIP) regulates adipogenesis and whole-body energy metabolism" by Chen et al., published in Bone Research. KIAA1199 as a key player in understanding bone-fat crosstalk! 👏 Congrats to @kmeblab.bsky.social & Moustapha Kassem! 📖 lnkd.in/eQKBDAU5

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BMAS @bma-society.bsky.social · 30/04/2025

Using histological and biochemical analyses, this new work by Mauro Maniglio, @LeaLoisay, Diego de Haro, Alexander Antoniadis, Thomas Hügle and @OA_Lab_CHUV from @RheumaLab_CHUV sheds light on a previously overlooked role of BMAT in osteoarthritis. (Link: www.oarsijournal.com/article/S106...

oarsijournal.com

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BMAS @bma-society.bsky.social · 30/04/2025

Announcing the @BMA_Society Paper of the Month for April 2025 ! Published in @OACJournal, this study identifies a previously unrecognized role of #BMAT #lipolysis in the sub-chondral neo-osteogenesis associated with hand #osteoarthritis.

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BMAS @bma-society.bsky.social · 15/04/2025

To receive FREE Registration for BMAS Summer School 2025 PLUS one-year BMAS membership! Come join our society by applying at: bma-society.org/bmas-summer-school-2025-program-awards/ This is a great opportunity to learn about #BMAT biology and join our vibrant and growing society!

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BMAS @bma-society.bsky.social · 15/04/2025

Exciting opportunity for #LMIC researchers in #bone and #adipose biology. Apply now for a Future Global Leaders Award sponsored by @BMA_Society and @IFMRS

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BMAS @bma-society.bsky.social · 14/04/2025

🚨 Don’t miss out! 🚨 💻 Join us TODAY at 11 AM EDT / 5 PM CEST for an insightful webinar on Neural Regulation of Bone Marrow Adipose Tissue with Dr. Erica L. Scheller from Washington University in St. Louis! 🇺🇸💡Discover how BMAT regulation plays a key role in conditions like starvation and cachexia. 🦴

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BMAS @bma-society.bsky.social · 03/04/2025

🚨🗣️ Exciting opportunity for LMICs researchers Apply now for the BMAS-IFMRS Future Global Leaders #award and receive FREE Summer School 2025 registration PLUS one-year BMAS membership waiver! This is a great opportunity to join the activities of this vibrant society! @ifmrs.bsky.social

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BMAS @bma-society.bsky.social · 31/03/2025

Post 2: Register at: umn-private.zoom.us/meeting/regi... This seminar will discuss the regulation of both regulated and constitutive #BMAT within the context of all #adipose tissues, and how this regulatory system evolves in states such as end stage starvation and cachexia.

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BMAS @bma-society.bsky.social · 31/03/2025

Post 1: Exciting news! The 6th @BMA_Society Webinar "Neural Regulation of Marrow Adipose Tissue is coming up on April 14, 2025 at 11 AM EDT / 5PM CEST featuring Dr. Erica Scheller (@schellerlab) from @wustlcrm @WashU_MRC and Moderated by Thomas Ambrosi and @LingQin6

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BMAS @bma-society.bsky.social · 31/03/2025

Posted at at bma-society.org/paper-of-the..., the study offers critical insights into the complex relationship between diet, bone health, and marrow adipose tissue (MAT). doi.org/10.1093/jbmr...

bma-society.org

Paper of the Month (BMAS) -

Each month, a recently published paper is selected for by the Scierntific Board of the to be spotlighted as out Paper of the Month.

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BMAS @bma-society.bsky.social · 31/03/2025

@bma-society.bsky.social The International BMAS is proud to highlight -Paper of the Month (March, 2025) -published in JBMR Plus! This study explores how a high-protein diet under caloric restriction affects muscle, bone, and marrow adipose tissue (MAT). doi.org/10.1093/jbmr...

doi.org

Low-calorie and high-protein diet has diverse impacts on the muscle, bone, and bone marrow adipose tissues

Abstract. The present study was designed to evaluate the influence of a high-protein diet under conditions of calorie restriction (CR) in the muscle, adipo

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BMAS @bma-society.bsky.social · 06/03/2025

🚨 @bma-society.bsky.social is excited to announce the 3rd BMAS Summer School 2025, held virtually from 24-26 September! Registration opens March 15th. This event is for graduate students, postdocs and young researchers interested in bone marrow adiposity. For more details visit our webpage 🗣️🖥️.

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BMAS @bma-society.bsky.social · 27/02/2025

📢 @bma-society.bsky.social Paper of the Month (February 2025): "Deep learning and genome-wide association meta-analyses of bone marrow adiposity" in @naturecomms.bsky.social This is a groundbreaking study! @naturecomms.bsky.social @BMATscientists from @EdinUniCVS and co-authors.

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BMAS @bma-society.bsky.social · 07/02/2025

The next BMAS webinar is Monday 10 February at 11am EST featuring @drgustavoduque.bsky.social from @mcgill.ca. Register to attend here: umn-private.zoom.us/meeting/regi...

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