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Reposted by Chancie T

Dan Jones @daniel-jones.bsky.social · 26/06/2026

Out now as a preprint, “Molecular basis of mitochondrial leucine transport by human Sideroflexin 1”. #CryoEM #Mitochondria #StructuralBiology www.biorxiv.org/content/10.6...

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MitoCarriers @mitocarriers.bsky.social · 06/12/2025

Here, we critically review the structures of the mitochondrial pyruvate carrier (MPC) in apo and ligand-bound states, highlighting controversies with regard to the orientation in the inner membrane, interpretation of the transport states, and modelling of the inhibitors. doi.org/10.1016/j.ti...

doi.org

Redirecting

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MitoCarriers @mitocarriers.bsky.social · 25/07/2025

Our review on the peculiar properties of mitochondrial carriers of the SLC25 family out: portlandpress.com/biochemj/art...

Characterised members of the human SLC25 mitochondrial family. Members of the mitochondrial carriers are shown in rainbow (blue to red) cartoon and surface representations with their primary substrates shown in sphere representations to scale. Only one paralogue is shown.

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Membrane Enzymology @membraneenzymology.bsky.social · 13/05/2025

Solène’s 4.5 years of postdoctoral work in our lab (she started just before the corona pandemic) has now been published. A heroic effort that revealed -at the single molecule level- that ATP drives the dissociation of an ECF transporter complex under turnover conditions. See rdcu.be/elTKc

rdcu.be

Single-molecule visualization of ATP-induced dynamics of the subunit composition of an ECF transporter complex under turnover conditions

Nature Communications - The association and dissociation dynamics of the ECF transporter complex for vitamin B12 are visualized by single-molecule FRET, highlighting the original transport...

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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 23/04/2025

A colder frontier in cryo-EM 🧪🔬 Chris Russo’s group, inc. Joshua Dickerson, adapted #cryoEM to work at liquid helium temperatures (13 kelvins), where every frame captured contains more information than the equivalent using liquid nitrogen (81 kelvins). Read more: tinyurl.com/mwwcunkc #LMBResearch

The electron cryo-microscope adapted for use at liquid nitrogen temperatures within its custom-made black box.

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MitoCarriers @mitocarriers.bsky.social · 18/04/2025

Our paper is finally out: Molecular basis of pyruvate transport and inhibition of the human mitochondrial pyruvate carrier | Science Advances www.science.org/doi/10.1126/... #mitochondria #cryo-EM

science.org

Molecular basis of pyruvate transport and inhibition of the human mitochondrial pyruvate carrier

The mitochondrial pyruvate carrier transport mechanism is ΔpH driven and is inhibited competitively by distinct compound classes.

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Da-Neng Wang @danengw.bsky.social · 06/01/2025

The work was a collaboration with Nate Traaseth. Hope the method will help others solve structures of small membrane proteins in multiple conformations. The fusion strategy can be seen as a tribute to the late Ron Kaback, who attempted a similar approach with crystallizing the LacY 30 years ago.

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Mark Peifer (He, him) @peiferlabunc.bsky.social · 06/01/2025

At the heart of biology is the mantra: structure dictates function.Biological structures are also beautiful in their intricacy. David Goodsell brought this into public view. As he leaves "Molecule of the Month". here's a huge thank you for helping me see more clearly🧪1/2 cdn.rcsb.org/rcsb-pdb/gen...

Pictures of a man with grey hair and a bear, a younger woman with shoulder length dark hair and a gallery of images of molecules from the link

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MitoCarriers @mitocarriers.bsky.social · 01/12/2024

Using 33 pathogenic variants of citrin we identify crucial elements of the carrier domain required for transport and show that the N-terminal domain is not involved in calcium regulation of transport, but causes a mitochondrial import defect, when mutated. www.sciencedirect.com/science/arti...

sciencedirect.com

Distinct roles for the domains of the mitochondrial aspartate/glutamate carrier citrin in organellar localization and substrate transport

Citrin, the mitochondrial aspartate/glutamate carrier isoform 2 (AGC2), is structurally and mechanistically the most complex SLC25 family member, beca…

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