npj Digital Medicine - Quantifying sleep wake rhythms in the hospital environment with digital technologies

Art as a multiplier of science communication - Volume 10 Issue 1

Scientific Reports - Critically ill patients with a reverse blood pressure dipping phenotype at increased risk for delirium and death

The vocal folds (VFs) are among the most mechanically active connective tissues, vibrating between 80 and 250 hz during speech. Overall VF function is determined by the composition and structure of...

AbstractBackground. Glioblastoma (GBM) is the most aggressive adult primary brain cancer, characterized by significant heterogeneity, posing challenges for

Wong et al. identify Slc6a2 as a marker of pulmonary venous endothelial cells and demonstrate that these cells differentiate into capillary endothelial cells during vascular regeneration after lung in...

Objective Electroencephalographic seizures (ES) are common in neonates with hypoxic–ischemic encephalopathy (HIE), but identification with continuous electroencephalographic (EEG) monitoring (CEEG) ...

TOX safeguards exhaustion biology in established Tex cells and restrains fate conversion to Teff cells.

The gold standard for assessing the function of human islets or β-like cells derived from stem cells involves their engraftment under the kidney capsule of

Using a cohort of nearly 1,000 genetically diverse mice undergoing dietary restriction over the lifespan, the authors reveal numerous insights into the interactions between the gut microbiome, host ge...

Common-variant and rare-variant association analyses combining datasets from multiple populations yield insights into the genetic architecture of all-cause heart failure across the allele-frequency sp...

Analysis of pre- and post-chemotherapy samples collected from 22 patients with high-risk neuroblastoma using single-nucleus RNA and ATAC sequencing and spatial omics characterizes therapy-related chan...

GIANT, a genetically informed brain atlas, integrates genetic heritability with neuroanatomy. It shows strong neuroanatomical validity and surpasses traditional atlases in discovery power for brain im...

Key Points. RBCs suspended in platelet-depleted plasma undergo aggregation within a thrombin-induced clot and cause platelet-independent clot shrinkage.RBC

CHAC1 is a kidney disease risk gene, and removal of one copy of Chac1 protects mice from kidney disease by controlling glutathione and ferroptosis.

In the past 10 years, CRISPR-Cas9 has revolutionized the gene-editing field due to its modularity, simplicity, and efficacy. It has been applied for the creation of in vivo models, to further understa...

The ability to study proteins in their native cellular context is crucial to our understanding of biology. In this work, we report a technology for intracellular protein editing, drawing from split intein–mediated protein splicing, genetic code expansion,...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Author summary Blood clots play a key role in serious conditions such as heart attacks and strokes. In this work, we utilized a computer model to understand how platelets, the key cellular components ...

Base editors can correct disease-causing genetic variants. After a neonate had received a diagnosis of severe carbamoyl-phosphate synthetase 1 deficiency, a disease with an estimated 50% mortality ...

PPP1R3B expression determines how hepatic energy is stored and changes contribute to liver damage and metabolic disease.

The status of immune cells within human pancreatic lymphatic tissues during the onset and progression of type 1 diabetes (T1D) is underexplored. Here, by flow cytometry and CITEseq, the authors profil...

AAV capsid variants enriched for transduction of ventricular lining cells and brain parenchyma reduce the dose required for gene therapy to the CNS.

The underlying mechanism of electroconvulsive therapy remains not fully understood. Here, the authors use optical neuroimaging in mice and humans to show that electroconvulsive therapy elicits a secon...

Rogers et al. show that psilocybin enhances fear extinction, suppresses fear neurons and recruits extinction neurons in the retrosplenial cortex in mice, providing evidence that its effects are linked...

Influenza viruses replicate and transcribe their genome in the context of a conserved ribonucleoprotein (RNP) complex. By integrating cryo–electron microscopy single-particle analysis and cryo–electro...

Zimislecel is an allogeneic stem cell–derived islet-cell therapy. Data on the safety and efficacy of zimislecel in persons with type 1 diabetes are needed. We conducted a phase 1–2 study of zimisle...

Chimeric antigen receptor (CAR) T cell therapies have transformed treatment of B cell malignancies. However, their broader application is limited by complex manufacturing processes and the necessity f...

Maroni et al. examine the effects of partial loss of the histone lysine methyltransferase DOT1L on neuronal development and function. Using zebrafish and m

Objective Aggregation of misfolded α-synuclein (aSyn) within the brain is the pathologic hallmark of Lewy body diseases (LBDs), including Parkinson's disease (PD), and dementia with Lewy bodies (DLB.....