How cumulative environmental allergen exposures are encoded by peripheral sensory neurons to shape immune responsiveness is unclear. Zhu et al. show that protease allergens induce an mTORC1-dependent,...

How cumulative environmental allergen exposures are encoded by peripheral sensory neurons to shape immune responsiveness is unclear. Zhu et al. show that protease allergens induce an mTORC1-dependent,...

How cumulative environmental allergen exposures are encoded by peripheral sensory neurons to shape immune responsiveness is unclear. Zhu et al. show that protease allergens induce an mTORC1-dependent,...

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How cumulative environmental allergen exposures are encoded by peripheral sensory neurons to shape immune responsiveness is unclear. Zhu et al. show that protease allergens induce an mTORC1-dependent,...

Thurimella et al. introduce a deep learning framework using protein language models to predict allergenic proteases in the microbiome. The model identified hundreds of candidate allergenic proteases i...

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Emerging research links the gut, skin, and oral microbiomes to allergies, with serine proteases (SPs) identified as potential allergens. This study le…

🤧 Why do we get allergies, and why do they make us itch, sneeze and swell? Caroline Sokol, MD, PhD, an allergy researcher at Mass General Brigham and the Food Allergy Science Initiative, is uncoverin...

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A γδ T cell–IL-3 signalling axis is defined that controls the allergen responsiveness of cutaneous sensory neurons, leading to evidence for an immune rheostat that governs sensory neuronal responses t...

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Mammals have evolved neurophysiologic reflexes, such as coughing and scratching, to expel invading pathogens and noxious environmental stimuli. It is …

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Dendritic cells (DCs) of the cDC2 lineage initiate allergic immunity and in the dermis are marked by their expression of CD301b. CD301b+ dermal DCs re…

A γδ T cell–IL-3 signalling axis is defined that controls the allergen responsiveness of cutaneous sensory neurons, leading to evidence for an immune rheostat that governs sensory neuronal responses t...

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The immune system intersects with almost every aspect of human health and disease. Its functions, both when things are going well and when things go wrong, are immensely complicated. The American Asso...

Luster and colleagues report that lung-resident ST2+ regulatory T cells secrete the IL-1 antagonist IL-1Ra to suppress neutrophils and early innate immune responses to influenza virus infection.