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Jang et al. measured dopamine and acetylcholine release in the striatum of rats performing a decision-making task and found that the relative timing of cholinergic and dopamine release gates whether dopamine promotes reinforcement learning or movement vigor.

An improved genetically encoded GABA sensor enables the most effective direct optical measurement of inhibitory neurotransmission to date.

Animals must align intestinal plasticity and feeding with reproductive state, yet the checkpoint that gates these adaptations is unknown. Here we show that an ovary-to-enteric-neuron axis gates the on...

Dopamine encoding of reward prediction errors naturally fluctuates over females’ reproductive cycles with estrogenic signaling due to reduced expression of dopamine reuptake proteins.

The atlas makes the most dangerous animal in the world a lot easier to study—and perhaps defeat one day.

A team of researchers has unveiled the complete connectome of a male fruit fly central nervous system —a seamless map of all the neurons in the brain and nerve cord of a single male fruit fly and the ...

Neuropeptide-guided plasticity of the clock neuron network operation enables behavioral adaptation to seasonal changes.

Understanding toxin resistance in insects is key to appreciate niche adaptations and for pest management, but remains challenging due to complex genetics. To investigate how Drosophila sechellia evolv...

Sexual selection acts on heritable differences within species, driving the parallel diversification of signal production in one sex and behavioral responses in the other. This coevolution implies that...

Gaucher disease (GD), the most common lysosomal storage disorder, is caused by bi-allelic mutations in the GBA1 gene. Variants in GBA1 also represent the most frequent genetic risk factor for Parkinso...

The Drosophila Genetic Database, FlyBase, is on the brink of collapse due to the sudden termination of the FlyBase NIH grant, which includes salaries for 5 literature curators based at the University ...

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Ribonucleoprotein granules (mRNP granules) are thought to contribute to the control of neuronal mRNA translation required for consolidation of long-term memories. Consistent with this, the function...