iiinova — where your digital self keeps evolving

cai000chen

@cai000chen.bsky.social

Reposted by cai000chen

Qi Chen @qichen-lab.bsky.social · 20/01/2026

Perhaps the most puzzling part: We see a paradox: the rsRNA length shift is progressive⏳yet the global RNA profile shows an "Aging Cliff"📉. Cliff or Progression? Maybe the gradual shift is the forerunner—accumulating silently until it triggers the cliff. bsky.app/profile/qich...

074

Reposted by cai000chen

Qi Chen @qichen-lab.bsky.social · 20/01/2026

1/5 It took us some time to connect the dots...now in @embojournal.org we use PANDORA-seq to start decoding the 'sperm RNA code of aging' We find a conserved rsRNA length shift that reflects aging in both mouse & human sperm, and an 'aging cliff' at mid-life🧵 link.springer.com/article/10.1...

194

Reposted by cai000chen

Qi Chen @qichen-lab.bsky.social · 20/08/2025

Perhaps our boldest hypothesis… we propose a model for RNA Structural Memory propagation in @natcellbio.nature.com where RNA conformation is reshaped by stress, locked by RBPs, copied prion-like in condensates & passed across generations—all without altering DNA rdcu.be/eBwPJ

182

Reposted by cai000chen

Qi Chen @qichen-lab.bsky.social · 20/08/2025

Proud to work with a brave team @cai000chen.bsky.social‬ @jianchengyu.bsky.social‬ Xudong Zhang & Tong Zhou—thinking fearlessly to bring this piece together. In a time of uncertainty, may this idea be a seed for spring… We’ll see what evidence we and the community can bring, to confirm or refute…

021