iiinova — where your digital self keeps evolving

Bryjalab @bryjalab.bsky.social · 07/10/2026

Happy we could be part of this story. 🤗 Definitely worth a read! 👀

Bryjalab @bryjalab.bsky.social · 25/09/2026

Please welcome the new Dr. in the house! 🎓 Our @antoniamikulova.bsky.social did a stunning job presenting and discussing her research on the origin of chronic lymphocytic leukemia and completed her PhD today. Big congrats! 😇

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Bryjalab @bryjalab.bsky.social · 22/09/2026

👀 Last Thursday was a special day for our lab! We held a mini-conference featuring the youngest generation of our lab as the main speakers, presenting the progress they made on their projects over the summer.🔬 👏 All ten did a great job, and we’re looking forward to seeing how their projects evolve!

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Bryjalab @bryjalab.bsky.social · 08/09/2026

Happy to see BryjaLab represented at the Biological Days conference in Brno! Thanks to the organizers for inviting @petrakompanikova.bsky.social to share her work! 🔥

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Bryjalab @bryjalab.bsky.social · 30/06/2026

Huge thanks to Elisa, a PhD student from Prof. Vittoria Colotta's lab (University of Florence), who finished her internship with us last week! 👋 Elisa joined us to test their CK1δ/ε inhibitors in our cell-based assays. It was a pleasure to have you, and we'll miss you in the Western blot room! 🎉

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Bryjalab @bryjalab.bsky.social · 07/06/2026

We love collaborations - especially across the campus! 🧬🙏 Our alumnus Miroslav Micka shares the story behind our long-standing collaboration with Konstantinos Tripsianes' lab @ceitec.eu that led to our recent Science Advances paper on Dishevelled protein 🎤👇 www.ceitec.eu/two-worlds-o...

ceitec.eu

Two Worlds, One Research Goal: How Collaboration Between Masaryk University Institutes Advanced the Study of Cell Signalling

What happens inside a cell at the very moment it decides its future? A recent study by two teams from Masaryk University (MUNI) brought new insight into this question by describing a key step in cellu...

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Bryjalab @bryjalab.bsky.social · 02/06/2026

Hallo from Belgium! 🧇 Our student @antoniamikulova.bsky.social sends greetings from her internship in the lab of @meningojan.bsky.social at VIB-KU Leuven Center for Cancer Biology where she studies immune cells in context of CNS pathologies.🧠 Many thanks to Jan and his group for their warm welcome 🙌

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Bryjalab @bryjalab.bsky.social · 25/05/2026

Walks, sports, cooking, singing around the campfire, and much more 🌿 That was our last week’s labretreat deep in the woods. Highly recommending the reset in nature. 💆‍♀️🌲

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Bryjalab @bryjalab.bsky.social · 10/05/2026

👋Greetings from Plön, where our master’s student Nela Kolčáková is doing an internship at @mpi-evolbio.bsky.social, diving into dev bio and evo-devo! Huge thanks to @marketa-kau.bsky.social and her lab for showing her the diversity of model organisms - from mice, fish to even lizards and sharks! 🐭🦎🦈

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Bryjalab @bryjalab.bsky.social · 08/05/2026

A look back at the 2nd EHA-SWG Scientific Meeting on MDS/MPN/AML, where our lab members Pavlína Janovská and Patrik Matušů presented their research on CK1 inhibition in AML and discussed its potential with leading hemato-oncologists. 🙏Thanks to everyone for the great meeting and valuable feedback!💊🥼

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Bryjalab @bryjalab.bsky.social · 13/04/2026

Big congrats to @petrakompanikova.bsky.social and Štěpán Čada on defending their PhDs last Friday 🎓 Thanks to everyone who came to celebrate their big day with us! 🍾🎉

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Bryjalab @bryjalab.bsky.social · 25/03/2026

Big thanks for the amazing work behind this study in @hemasphere-journal.bsky.social - especially first author @antoniamikulova.bsky.social, all collaborators and funding from Czech Science Foundation, Ministry of Health of the Czech Republic & National Institute for Cancer Research 🙏

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Bryjalab @bryjalab.bsky.social · 25/03/2026

Proud to share our new paper! 🎉🍾 To cure chronic lymphocytic leukemia (CLL), it might be hard to determine what to target first - the intrinsic machinery of CLL cells or the pro-leukemic microenvironment? This study shows that casein kinase 1δ/ε inhibition does both, leading to CLL suppression.👀👩‍🔬🧵

onlinelibrary.wiley.com

Casein kinase 1δ/ε inhibition suppresses CLL proliferation through cell‐intrinsic and microenvironmental mechanisms

Chronic lymphocytic leukemia (CLL) is a consequence of pathological B-cell accumulation in blood and lymphoid organs. Due to high refractoriness, CLL is still incurable in many cases; therefore, ther...

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Bryjalab @bryjalab.bsky.social · 14/12/2025

🎤 Another day, another interview (cz) This time our PI Víťa appears in the latest issue of @vesmir.bsky.social - a Czech popular science journal - talking about his academic journey and focus on cell signalling and leukemia research. 🧑‍🔬 👇 vesmir.cz/cz/casopis/a...

vesmir.cz

Jen počkej, leukemie!

Řidičů tramvaje nebo popelářů jsou plné mateřské školky. Čas tuhle ranou romantiku setře, díky čemuž občas patentový úřad zaznamená nový vynález nebo lidstvo obohatí své poznání o dosud neznámou zákon...

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Bryjalab @bryjalab.bsky.social · 13/12/2025

Something a bit different for the weekend 🎥 🎤 An interview from French BFMTV (EN) featuring our PI Víťa, this time as a founder of CasInvent - a company developing selective Casein Kinase 1 inhibitors 🔬 Worth a watch 👇 www.bfmtv.com/pratique/ent...

bfmtv.com

CasInvent : la biotech tchèque qui ouvre une nouvelle voie contre les cancers résistants

Depuis Brno, en République tchèque, CasInvent se distingue par une approche inédite dans la lutte contre les cancers les plus agressifs. Issue de l’Université Masaryk, la jeune biotech développe une n...

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Bryjalab @bryjalab.bsky.social · 12/12/2025

Big congrats to our PhD student Patrik Matušů on winning the Brno PhD Talent award for his project on CK1 and AML 🎉 Very well deserved 👏 www.jcmm.cz/projekt/brno...

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Bryjalab @bryjalab.bsky.social · 12/10/2025

Also proud of our lab members — Olga Vondálová Blanářová, Michaela Chorvátová, Nela Kolčáková, Hana Plešingerová & Pavlína Janovská — for their excellent poster presentations! 👏 See you at the next edition! @csac-cz.bsky.social

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Bryjalab @bryjalab.bsky.social · 12/10/2025

Big Bryjalab delegation at the 13th International Conference on Analytical Cytometry in beautiful Mikulov! Many thanks to the organizers for such a wonderful meeting & Bike scientific discussion. 🚴‍♀️ Proud of our PhD students @antoniamikulova.bsky.social and Štěpán Čada for their great talks! 🤗🧵

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Bryjalab @bryjalab.bsky.social · 27/09/2025

🎉 Pleased to collaborate again with Buchtová lab, where @petrakompanikova.bsky.social’s bioinformatics skills contributed to uncovering new roles of LGR5 in the formation of teeth 👩‍💻🐁

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Bryjalab @bryjalab.bsky.social · 23/09/2025

🤗 This work would not have been possible without the fantastic collaboration between our lab and K. Tripsianes’ lab at @ceitec.eu. Also, huge thanks to our funding sources — the Czech Science Foundation & the Ministry of Education, Youth and Sports. 👏

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Bryjalab @bryjalab.bsky.social · 23/09/2025

🧐In a nutshell: CK1-mediated multisite phosphorylation of Dishevelled dramatically alters its bulk electrostatics, promoting DVL intramolecular coupling between the positively charged cleft of the DEP domain and the adjacent phosphorylated disordered region.

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Bryjalab @bryjalab.bsky.social · 23/09/2025

Excited to share our new preprint on bioRxiv. 🎉 We uncovered a Wnt-induced phospho-switch of Dishevelled. This intramolecular coupling is mutually exclusive with FZD engagement and functionally required for the Wnt/β-catenin signaling. 🧵 doi.org/10.1101/2025...

doi.org

A Wnt-induced conformational phospho-switch in DVL3 controls interaction with Frizzled receptors and Wnt/β-catenin signaling

When Wnt ligands bind to Frizzled (FZD) receptors, Dishevelled protein (DVL) gets multiphosphorylated by Casein kinase 1 (CK1). Although, it is well known that DVL phosphorylation relays Wnt signals f...

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Bryjalab @bryjalab.bsky.social · 13/09/2025

Many thanks @chriswaudby.bsky.social , and also to @michaelranes.bsky.social and Lucie Wolf, for coming all the way to Brno and doing such an excellent job as examiners. 👏

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Bryjalab @bryjalab.bsky.social · 13/09/2025

Big day for Bryjalab yesterday! Mirek Micka & Tomáš Gybeľ nailed their defences — welcome to the PhD club! 🎓🔥 Thanks to everyone who supported them along the way and came to celebrate! 🎉🤗

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Bryjalab @bryjalab.bsky.social · 13/09/2025

Day 2 of our Milestone minisymposium at @ceitec.eu in Brno was packed with excellent talks by Lucie Wolf from Stephane Angers’ lab at @utoronto.ca, followed by @cajaneklab.bsky.social and Víťa as the closing speaker. 🔥

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Bryjalab @bryjalab.bsky.social · 11/09/2025

The science marathon continues. 🏃 Straight off #EBBM2025, BryjaLab is co-organizing with Tripsianes’ lab at @ceitec.eu the Milestone Minisymposium on Cell Signalling, kicking off today with great talks by @chriswaudby.bsky.social & @michaelranes.bsky.social. More talks & two PhD defenses tomorrow 🎓

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Bryjalab @bryjalab.bsky.social · 10/09/2025

Grind stays real – Víťa and @petrakompanikova.bsky.social went straight from the V4SDB Meeting 2025 to the European Brain Barrier Meeting in Bern, where Petra presented her work on the hindbrain choroid plexus. 🐁 Big thanks to the organizers and community for the warm first-time welcome! 😇 #EBBM2025

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Bryjalab @bryjalab.bsky.social · 09/09/2025

Big shout-out to @sumbalovakoledova.bsky.social, Marcela Buchtová, Alexandra Špirková & our PhD student @petrakompanikova.bsky.social, who also presented a poster on her Choroid Plexus development story, for organizing such an excellent meeting 🔥

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Bryjalab @bryjalab.bsky.social · 09/09/2025

Last week we joined the @v4sdb.bsky.social Meeting 2025 in the beautiful High Tatras 🌄 with an amazing lineup of speakers and posters 🔥 So good to see this society still rocking!

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Bryjalab @bryjalab.bsky.social · 14/08/2025

And huge thanks for the support @biologists.bsky.social, @ceitec.eu, @uebscimuni.bsky.social, Milestone & CasInvent Pharma 🤗🎉

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Bryjalab @bryjalab.bsky.social · 14/08/2025

First-ever CK1 Protein Kinase Family conference took place in Brno, bringing together nearly 80 researchers from around the world to share the latest findings on CK1 biology, disease links, and therapeutic potential. Thanks for the inspiring talks, posters & great networking – see you next time! 🎉🥳

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Bryjalab @bryjalab.bsky.social · 26/02/2025

🎉 We’re thrilled to announce that the MILESTONE International CK1 Conference is happening July 21–23, 2025, in Brno, CZ! 🫛 Join us to explore CK1 kinases in cell signaling, cancer, neurodegeneration, therapy & more! Registration’s open now! Looking forward to meeting you all there! 🤗 ck1.sci.muni.cz

ck1.sci.muni.cz

MILESTONE International Conference | MILESTONE International Conference CK1 | MUNI SCI

CK1 protein kinase family: From cell signaling to therapeutic targets in human disease

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Bryjalab @bryjalab.bsky.social · 18/02/2025

🍾 New preprint alert! We were happy to methodologically participate in the project that targets the regulation of RNA Polymerase II transcription by RECQ5-mediated LLPS. 🧊🔬 Huge thanks to the Richard Štefl Lab and @labvacha.bsky.social for this opportunity! 🤗 www.biorxiv.org/content/10.1...

biorxiv.org

Mechanisms of transcription attenuation and condensation of RNA polymerase II by RECQ5

The elongation rates of RNA polymerase II (RNAPII) require precise control to prevent transcriptional stress, which can impede co-transcriptional pre-mRNA processing and contribute to many age- or dis...

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Bryjalab @bryjalab.bsky.social · 07/02/2025

🤗 A huge thanks to the Czech Science Foundation and the National Infrastructure for Chemical Biology for supporting our work on CK1 δ/ε degraders! Stay tuned for more CK1 biology updates! 👩‍🔬

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Bryjalab @bryjalab.bsky.social · 07/02/2025

📌AH078 is a powerful tool for studying CK1 δ/ε biology in cells, enabling rapid depletion of both kinases—something challenging with KO systems due to cellular dependency on CK1 δ/ε activity!

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Bryjalab @bryjalab.bsky.social · 07/02/2025

👉 The PROTAC AH078 is characterized through in vitro and cellular assays, demonstrating on-target activity, selectivity, and a VHL-dependent mechanism of the CK1 degradation in cells.

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Bryjalab @bryjalab.bsky.social · 07/02/2025

🥳New paper from the lab!🍾 Excited to share our work with the Stefan Knapp lab (Goethe Uni, @thesgc.bsky.social & DKTK), published in J. Med. Chem. @pubs.acs.org. Here, we present the first degraders (PROTACs) targeting CK1 δ/ε—highly selective across the kinome & within the Casein kinase 1 family. 🧵

pubs.acs.org

Development and Discovery of a Selective Degrader of Casein Kinases 1 δ/ε

Members of the casein kinase 1 (CK1) family have emerged as key regulators of cellular signaling and as potential drug targets. Functional annotation of the 7 human isoforms would benefit from isoform...

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Bryjalab @bryjalab.bsky.social · 03/02/2025

📢 Greetings from Dundee! Our PhD student Tomáš Gybeľ sends his best from his internship in the Sapkota lab at the University of Dundee, where he is studying CK1 and the Fam83 protein family in Wnt signaling. 🌍🔬 Big thanks to Prof. Sapkota and his team for their warm welcome and support! 🤗

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Bryjalab @bryjalab.bsky.social · 28/01/2025

Bryjalab attended the 25th Prague Hematology Days 🩸, presenting our work on ROR1+ B cells in CLL, CK1 inhibitors in AML, and the effect of CK1 inhibition + Venetoclax on specific AML clones. 👩‍⚕️👩‍🔬 Huge thanks to the organizers for the chance to share our research with scientists and clinicians! 🤗

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Bryjalab @bryjalab.bsky.social · 27/01/2025

Our PhD student @petrakompanikova.bsky.social is helping organize this amazing conference with a really impressive lineup of invited speakers. Follow her and @v4sdb.bsky.social for updates, and hope to see you all in the High Tatras!

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Reposted by Bryjalab

Petra Kompanikova @petrakompanikova.bsky.social · 25/01/2025

Today, during the Open Day at the Faculty of Science, Masaryk University, I had the chance to help my department showcase our research and guide prospective bachelor students through our labs. 🔬🧪 I hope we sparked some interest and inspired a future scientist! ✨👩‍🔬👨‍🔬

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Bryjalab @bryjalab.bsky.social · 20/01/2025

Lastly, we would like to thank the Czech Science Foundation, National institute for cancer research, @ciisbinstructcz.bsky.social and e-infra.cz for their support and resources. 🤗 Stay tuned for more updates! 🐟🔬✨ #Wnt #PCP #CellBiology #DevelopmentalBiology #CancerResearch #NGEU

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Bryjalab @bryjalab.bsky.social · 20/01/2025

This work wouldn’t have been possible without our excellent team—especially our incredible co-shared first authors, @kgomory.bsky.social, Nikodém Zezula and Tomasz Radaszkiewicz

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Bryjalab @bryjalab.bsky.social · 20/01/2025

Why does this matter? The Wnt/PCP pathway plays a critical role in developmental biology, tissue organization, and the hallmarks of cancer. Dysfunctions in this pathway can result in severe developmental defects or contribute to cancer progression.

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Bryjalab @bryjalab.bsky.social · 20/01/2025

This study not only uncovers novel components of the Wnt/PCP pathway but also provides a comprehensive resource for further exploration of Wnt/PCP function in vertebrates. 🌟

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Bryjalab @bryjalab.bsky.social · 20/01/2025

Further, we analyzed these proteins in melanoma cell lines. Loss of the endogenous level of their expression lead to the inhibition of the cancer cells migration, further validating our results.

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Bryjalab @bryjalab.bsky.social · 20/01/2025

Among the candidates, three stood out as essential: •RAI14 •EPHA2 •PHACTR4 These proteins are key for Wnt/PCP processes like: ✅ Zebrafish convergent extension ✅ Orientation of lateral organ cells

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Bryjalab @bryjalab.bsky.social · 20/01/2025

By analyzing individual preys across baits and their subcellular locations, we identified 30 candidate proteins that might play a role in Wnt/PCP signaling. To validate these, we performed loss-of-function studies in zebrafish. 🐟

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