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Brooke O'Donnell

@brookeodonnell.bsky.social
36 followers 39 following 6 posts

PhD👩🏼‍🔬🇨🇦 | Post-doctoral Fellow | Isakson Laboratory | CVRC University of Virginia 🧡💙 (she/her)

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Brooke O'Donnell @brookeodonnell.bsky.social · 04/12/2025
Excited to announce the final versions of my paper on the role of the internal elastic lamina in resistance arteries and my review on pannexins in the vasculature are out! Thank you to the co-authors for your great work! Links below
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Brooke O'Donnell @brookeodonnell.bsky.social · 17/09/2025
Thanks to @UVACVRC for the shoutout! Happy National Postdoc Appreciation Week 🎉
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Reposted by Brooke O'Donnell
Manuel F. Navedo @mfnavedo.bsky.social · 15/08/2025
The official release of our manuscript examining arterial myocyte Panx1 role in diabetic vascular dysfunction is out! Massive effort to uncover new mechanisms underlying vascular disease. Power of science! @ucdavis.bsky.social, @ucdavispharm.bsky.social www.ahajournals.org/doi/10.1161/...
ahajournals.org
Arterial Myocyte Pannexin 1 Channel Controls Vascular Reactivity in Diabetic Hyperglycemia | Circulation Research
BACKGROUND: Diabetic hyperglycemia promotes vasoconstriction by activating an ATP-dependent P2Y11L (P2Y11-like receptor)/AC5 (adenylyl cyclase 5)/AKAP5 (A-kinase anchoring protein 5)/PKA (protein kina...
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Brooke O'Donnell @brookeodonnell.bsky.social · 11/07/2025
Grateful to have been a part of this exciting story!
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Reposted by Brooke O'Donnell
Brant Isakson @brantisakson.bsky.social · 21/04/2025
Some of the strong work by Melissa Luse rounding her PhD. Love the story, and I think it opens up some new ideas in endothelial lipid handling and overall questions roles for NO… www.ahajournals.org/doi/10.1161/...
ahajournals.org
Nitrosation of CD36 Regulates Endothelial Function and Serum Lipids | Arteriosclerosis, Thrombosis, and Vascular Biology
BACKGROUND: During obesity, endothelial cells (ECs) become lipid laden, leading to endothelial dysfunction. We tested posttranslational modification on CD36 that may regulate EC lipid accumulation. ...
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Brooke O'Donnell @brookeodonnell.bsky.social · 01/04/2025
Was great to be back for the 13th Conference on Signalling in Normal and Cancer Cells to present my work on the effect of PANX1 phosphorylation in the vasculature 🍁 thanks to the organizers @jf-cotelab.bsky.social for a great week and my previous lab mates @drsilviapenuela.bsky.social for the visit!
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