Reposted by Britta VeltenAnnique Claringbould @anniquec.bsky.social · 12/03/2026🧬 How do immune disease-relevant variants affect gene regulatory networks in CD4+ T cells? 🧪🖥️ We coupled two large-scale CRISPRi screens (>4M cells) to map the downstream cascades of thousands of SNPs More details in the thread below 👇 or in the article 📖 on biorxiv tinyurl.com/CD4screens 12811
Reposted by Britta Veltendanielschraivogel.bsky.social @danielschraivogel.bsky.social · 12/03/2026Very proud to see this work out on bioRxiv. Using genome-scale TAP/Perturb-seq we mapped the function of immune-disease variants to target genes and regulatory cascades. Have a look at the 🧵from @anniquec.bsky.social for more info! 073
Britta Velten @brittavelten.bsky.social · 10/12/2025A new lab preprint is up: Work led by our MSc student Jan Sprengel comparing Interventional Causal Structure Learning Algorithms for Gene Regulatory Network Inference from single cell CRISPR perturbation screens 👇 www.biorxiv.org/content/10.6...biorxiv.orgComparison of Interventional Causal Structure Learning Algorithms for Gene Regulatory Network InferenceBackground: Causal structure learning offers a promising approach to studying gene regulation in cells, aiming to provide deeper mechanistic insights than purely association-based methods. Theoretical... 0168
Britta Velten @brittavelten.bsky.social · 03/12/2025Happy to see this out now in Cell Genomics: A genome-scale single-cell CRISPRi map of trans gene regulation across human pluripotent stem cell lines: www.cell.com/cell-genomic...cell.comA genome-scale single-cell CRISPRi map of trans gene regulation across human pluripotent stem cell linesFeng et al. present the first genome-scale CRISPR interference perturbation map with scRNA-seq readout across many genetic backgrounds in human pluripotent cells, pioneering population-scale CRISPR pe... 32710
Reposted by Britta VeltenLars Velten @larsplus.bsky.social · 20/11/2025We are looking for a postdoc to join our team! If you're interested in translating a cutting edge genomics technology (www.nature.com/articles/s41...) to real-life applications in hematology, this is for you. We offer a unique working environment ON THE BEACH: recruitment.crg.eu/content/jobs... 01716
Reposted by Britta VeltenUniversität Heidelberg @uniheidelberg.bsky.social · 16/10/2025Auszeichnung für Heidelberger Datenwissenschaftlerin: Britta Velten wird für innovative Verfahren für die Analyse von komplexen Datensätzen aus den Lebenswissenschaften mit dem Early Excellence in Science Award ausgezeichnet www.uni-heidelberg.de/de/newsroom/... #uniheidelberg #lifescience 1203
Britta Velten @brittavelten.bsky.social · 16/10/2025Extremely honoured to receive the Bayer foundation early excellence in science award. Thanks to all my team, colleagues, collaborators and mentors for making this possible! 1171
Britta Velten @brittavelten.bsky.social · 08/10/2025Very nice framework to handle missing values in proteomics data by combining probabilistic factor models (alike MOFA) and suitable likelihood functions to account for values missing not at random. Take a look 👇 040
Reposted by Britta VeltenWolfgang Huber @wkhuber.bsky.social · 29/09/2025Do you like theoretical biology, mathematical&conceptual modelling and want to apply yourself to cutting-edge research at all levels of biology, from molecules to ecosystems? Come to EMBL! Scope includes physics-based models, emergence, statistics, ML/AI embl.wd103.myworkdayjobs.com/en-US/EMBL/j... 04535
Reposted by Britta VeltenEwan Birney @ewanbirney.bsky.social · 08/09/2025Are you an AI expert who wants to stay in academia and change the world by understanding the most complex things we know - living organisms? Want to lead your own group, based in Heidelberg DE, working language English? @embl.org is hiring in AI embl.wd103.myworkdayjobs.com/en-US/EMBL/j...embl.wd103.myworkdayjobs.comGroup Leader – AI in BiologyAre you ready to lead groundbreaking research in AI for Biology? Join us at EMBL! We are seeking a visionary scientist to establish their own independent research group bridging innovations in machine... 23630
Reposted by Britta VeltenEMBL Events @events.embl.org · 17/09/2025Welcome to day 4 of #EMBOBioImage 🖥️ 👉Happening right now: practical session 5, spatial statistics and omics integration, led by @brittavelten.bsky.social, assisted by Anna Klemm. 083
Reposted by Britta VeltenIgnacio Arganda-Carreras @iarganda.eurosky.social · 17/09/2025And here we go again with Day 4️⃣ of the @embo.org course on "Advanced methods in bioimage analysis"! 🔬🖥️📊 We just started "Pratical session 5: Spatial statistics and omics integration" with @brittavelten.bsky.social and her team 💪 from @uniheidelberg.bsky.social ... 1191
Reposted by Britta VeltenJunyan Lu @junyanlu.bsky.social · 22/07/2025🔬 PhD Position in Bioinformatics! Join my group at Heidelberg University (lu-group-ukhd.github.io) to study AML dormancy & therapy resistance using multi-omics & single-cell data. 👉Apply or share: www.jobvector.de/job/bioinfor...jobvector.dePhD Student Bioinformatics, Computational Biology (m/f/d)Analyze bulk and single-cell multi-omics data generated from in vivo AML models Curate and integrate public datasets (eg scRNA-seq) to derive prior knowledge on AML dormancy Develop and apply integrat... 043
Britta Velten @brittavelten.bsky.social · 03/07/2025Exciting kick-off meeting for our spatial omics seminar in and around Heidelberg organised with @tanevski.bsky.social and @denisschapiro.bsky.social. Was fun to see all the cool research happening here and connect. Reach out to us if you missed out and would like to join the next meetings! 0101
Britta Velten @brittavelten.bsky.social · 25/06/2025🚀 Job opportunity: Bioinformatics Software Engineer Join a young and passionate team at Heidelberg University to advance bioinformatics software that drive biological discovery. Learn more & apply 👉 shorturl.at/GCpg7shorturl.atBioinformatics Software EngineerPost a job in 3min, or find thousands of job offers like this one at jobRxiv! 053
Britta Velten @brittavelten.bsky.social · 29/04/2025Looking forward to meeting up with the spatial biology community in October! Join us in Heidelberg :-) 070
Britta Velten @brittavelten.bsky.social · 15/04/2025Do you want to advance scientific software for the life sciences? Join us now in Heidelberg as a scientific software developer. Details can be found here: shorturl.at/vqpEAshorturl.atScientific Software DeveloperPost a job in 3min, or find thousands of job offers like this one at jobRxiv! 042
Britta Velten @brittavelten.bsky.social · 31/01/2025JOB OPPORTUNITY: Join us as a scientific programmer to advance tools for multi-omics data at Heidelberg University. Details can be found at shorturl.at/OcnOa and please spread the word!shorturl.atScientific programmerPost a job in 3min, or find thousands of job offers like this one at jobRxiv! 0711
Reposted by Britta VeltenWolfgang Huber @wkhuber.bsky.social · 24/01/2025CompBio method developers: software that only runs on your computer and is not available via a repository like CRAN, PyPI, Bioconductor, is not a proper research output — just like a set of scribbled notes on your desktop is not the same as a preprint or a paper. Finish the job. 45314
Britta Velten @brittavelten.bsky.social · 14/01/2025My first post here on BlueSky to share our recent work with Claudia Feng and @leopoldparts.bsky.social - a large-scale single cell CRISPR screen to chart out gene regulation and the role of genomic background in iPSCs. Check out the data here: www.sanger.ac.uk/tool/crispri... 0256