A new preprint is out by our PhD student, Lindsey Riggs! We reveal a hidden interaction network in an IDP that connects a mutation site to distant regions through transient tertiary interactions. Beneath the disorder lies an underlying network! Read here: chemrxiv.org/doi/full/10....
chemrxiv.org
A tertiary network couples hydrophobic substitutions to terminal contacts in an IDP | ChemRxiv
Conformational ensembles of intrinsically disordered proteins (IDPs) are sensitive
to changes in amino acid sequence. Even chemically conservative substitutions can
alter global properties and interac...
