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Brandon S. Cooper

@brandonscooper.bsky.social
113 followers 79 following 9 posts

Dad. Associate Professor U. Montana. Evolutionary genetics and endosymbiosis mostly. cooper-lab.org

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Brandon S. Cooper @brandonscooper.bsky.social · 18/06/2026
I’m super fortunate to work with these great scientists and many others that made critical contributions! They include W. Conner, A. Hoffmann, M. Turelli, B. Sullivan, and D. Vanderpool. More to come soon, including from recent PhD grad John Statz, who is moving on to a great postdoc. 🤘
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Brandon S. Cooper @brandonscooper.bsky.social · 18/06/2026
Finally, Hunter Hill used In(1)w^m4 (one of the original X-chroms from Muller's 1930 paper) to show Wolbachia acts as a variegation suppressor. Wolbachia-mediated modification of paternal chromatin during spermatogenesis leaves a persistent signature on heterochromatin-mediated silencing. Very cool
biorxiv.org
Wolbachia-induced cytoplasmic incompatibility produces heritable chromatin modifications that suppress position-effect variegation
Maternally transmitted Wolbachia often cause cytoplasmic incompatibility (CI), a sperm modification that kills host embryos lacking the endosymbiont. CI produces defects in paternal chromosome replica...
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Brandon S. Cooper @brandonscooper.bsky.social · 18/06/2026
#3 Nitin Ravikanthachari shows climate predicts wMel frequency in D. mel across 248 locations/5 continents. With E. Behrman, J. Beltz, & P. Schmidt, we show week-to-week/seasonal freq variation related to temp. We also show that env-allele associations reflect lineage history, not local adaptation.
biorxiv.org
Climate predicts wMel Wolbachia frequency variation in Drosophila melanogaster, but genomic variation reflects a recent incomplete cytoplasmic sweep
Maternally transmitted Wolbachia occupy roughly half of terrestrial arthropod species, but the factors maintaining their variable population frequencies are poorly understood. In Drosophila melanogast...
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Brandon S. Cooper @brandonscooper.bsky.social · 18/06/2026
#2 Led by Basabi Bagchi and Dylan Shropshire assesses temperature modulation of cytoplasmic incompatibility strength across 8 systems. With the help of Lore, Tim (Phd), and Elena/Kyle (undergrads), we show cifB expression partly explains temp-sensitive CI, while bacterial density in testes does not.
biorxiv.org
Temperature-sensitive cytoplasmic incompatibility across divergent Wolbachia partly reflects cifB transcription, not endosymbiont density
Maternally transmitted Wolbachia bacteria are common in insects, with many strains altering host reproduction through cytoplasmic incompatibility (CI). CI kills embryos fertilized by Wolbachia -bearin...
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Brandon S. Cooper @brandonscooper.bsky.social · 18/06/2026
Dylan's paper focuses on Wolbachia molecular evolution and calibrating the timescale of horizontal transfers between divergent host species. We compare our calibration to alternatives and use it to understand how quickly genes that cause and rescue cytoplasmic incompatibility are gained and lost.
doi.org
Calibrating and documenting host-switching and evolution of incompatibility loci for two closely related Wolbachia clades
Abstract. Maternally inherited Wolbachia alphaproteobacteria are the most common arthropod endosymbionts. Often, Wolbachia spread to high frequencies throu
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Brandon S. Cooper @brandonscooper.bsky.social · 18/06/2026
The lab has several new papers out led by fantastic postdocs, with important contributions from other lab members and collaborators. Each paper focuses on different aspects of Wolbachia spread and effects on hosts. The first paper was led by Dylan Shropshire and is now in Genetics.
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Reposted by Brandon S. Cooper
Dan Schrider @samurscicop.bsky.social · 18/06/2026
Postdoc search update! I am continuing to solicit applications for a postdoc opening in the lab, and probably around the beginning of July I will start selecting applicants to interview. See evoldir ad here: evoldir.net/brian/evoldi... Please RT or whatever!
evoldir.net
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Reposted by Brandon S. Cooper
Hunter Hill @hunterhill.bsky.social · 18/06/2026
Excited to share this preprint!! with @brandonscooper.bsky.social and Bill Sullivan We tested whether endosymbiotic Wolbachia can alter host gene expression through chromatin modifications that persist from spermatogenesis to adulthood.
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Reposted by Brandon S. Cooper
bioRxivpreprint @biorxivpreprint.bsky.social · 17/06/2026
Wolbachia-induced cytoplasmic incompatibility produces heritable chromatin modifications that suppress position-effect variegation www.biorxiv.org/content/10.64898/20…
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Reposted by Brandon S. Cooper
bioRxiv Evolutionary Biology @biorxiv-evobio.bsky.social · 25/05/2026
Climate predicts wMel Wolbachia frequency variation in Drosophila melanogaster, but genomic variation reflects a recent incomplete cytoplasmic sweep www.biorxiv.org/content/10.64898/20…
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Reposted by Brandon S. Cooper
bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 02/04/2026
Temperature-sensitive cytoplasmic incompatibility across divergent Wolbachia partly reflects cifB transcription, not endosymbiont density www.biorxiv.org/content/10.64898/20…
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Reposted by Brandon S. Cooper
bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 15/02/2026
Calibrating and documenting host-switching and evolution of incompatibility loci for two closely related Wolbachia clades www.biorxiv.org/content/10.64898/20…
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Reposted by Brandon S. Cooper
Nancy Moran @nancy-moran.bsky.social · 29/05/2025
Looking for a postdoc on bacterial-insect symbiosis, combining evolution and molecular mechanisms? I'll have one open in my lab starting Sept 2025. If interested contact me (or find me at the GRC on Animal-microbe symbiosis if you'll be there). #SymbioSky
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Brandon S. Cooper @brandonscooper.bsky.social · 19/02/2025
Matt, I’m so sorry that this happened. You and other POs have always been such great colleagues. Thank you for all of your thoughtful and hard work at the NSF.
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Reposted by Brandon S. Cooper
Brandon S. Cooper @brandonscooper.bsky.social · 08/12/2024
We are hiring an Assistant Professor of Microbiology, Immunology & Infectious Disease (broadly defined) at the University of Montana. Great colleagues in a great place. I’m happy to answer any questions. Please apply! apply.interfolio.com/159494
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Brandon S. Cooper @brandonscooper.bsky.social · 09/12/2024
First, hey, Graham! Long time—hope you are great. Agree. Our EE group does this annually. We introduce our year, go out of room, they discuss our effort (res, teach, serv) and vote (merit, normal, etc). It’s wonderful to keep up with the work of our colleagues. Very rewarding (and often humbling).
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Brandon S. Cooper @brandonscooper.bsky.social · 08/12/2024
We are hiring an Assistant Professor of Microbiology, Immunology & Infectious Disease (broadly defined) at the University of Montana. Great colleagues in a great place. I’m happy to answer any questions. Please apply! apply.interfolio.com/159494
apply.interfolio.com
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
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