iiinova — where your digital self keeps evolving

Reposted by Aaron Boster MD

brandon-beaber.bsky.social @brandon-beaber.bsky.social · 01/12/2025

The NEW 2024 MS Diagnostic Criteria Explained by @aaronbostermd.bsky.social RIS, kappa light chain in CSF, central vein sign, paramagnetic rim sign, anti-MOG in children, age > 50. youtu.be/HOTDtZQLo2k?...

youtu.be

The NEW 2024 MS Diagnostic Criteria Explained (Game-Changer!)

YouTube video by Aaron Boster MD

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Reposted by Aaron Boster MD

Sarah McAnulty, Ph.D. @sarahmackattack.bsky.social · 07/10/2025

Alie Ward is doing a live show for @ologies.bsky.social on November 17 in Neewwww Yorkkkk Citaayyyy and you better be there. I'll be there. Tickets go on sale Thursday, but if you're a patron of ologies you just got a presale link in your inbox 👀 www.ticketmaster.com/event/300063...

Alie points at a lightning bug in her hand excitedly in a mustard yellow sweater.

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Reposted by Aaron Boster MD

brandon-beaber.bsky.social @brandon-beaber.bsky.social · 06/10/2025

Does Obesity Make Multiple Sclerosis Get Worse Faster? Very important data shared by @aaronbostermd.bsky.social youtu.be/9UJXK_tKqUg?...

youtu.be

Does Obesity Make Multiple Sclerosis Get Worse Faster?

YouTube video by Aaron Boster MD

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Reposted by Aaron Boster MD

brandon-beaber.bsky.social @brandon-beaber.bsky.social · 06/10/2025

Ocrevus was superior to gilenya in pediatric MS in a head to head trial (OPERETTA 2 trial) with 48% fewer relapses (annual relapse rate of 0.07 vs 0.14) along with "greater reductions in disease activity on brain imaging." www.medscape.com/viewarticle/...

medscape.com

Head-to-Head Trial Supports New Treatment for Kids With MS

A multicenter phase 3 trial comparing ocrelizumab to fingolimod for children with MS achieved its noninferiority primary endpoint while suggesting potential safety advantages.

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Reposted by Aaron Boster MD

Christen Rexing, PhD, MPH @christenrexing.bsky.social · 30/09/2025

For no reason at all…

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Reposted by Aaron Boster MD

Prof G @gavingiovannoni.bsky.social · 29/09/2025

#MS_Selfie ECTRIMS 2025: blowing my own horn The highlight of the meeting was my presentation of the ocrelizumab results in the PPMS O’HAND study, which were positive. buff.ly/EWHOuBw

gavingiovannoni.substack.com

ECTRIMS 2025: blowing my own horn

The highlight of the meeting was my presentation of the ocrelizumab results in the PPMS O’HAND study, which were positive.

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Reposted by Aaron Boster MD

brandon-beaber.bsky.social @brandon-beaber.bsky.social · 29/09/2025

"We found to a gene which predicts MS prognosis!" Beware of this highly dubious claim in scientific publications as very frequently, a replication study fails to recapitulate the finding (table 5 of the linked article). www.neurology.org/doi/10.1212/...

neurology.org

Unlocking Multiple Sclerosis Genetics | Neurology

Multiple sclerosis (MS) is a clinically diverse and unpredictable CNS disorder. The considerable heterogeneity in disease course between people with MS is believed to reflect the varying magnitude and...

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Reposted by Aaron Boster MD

brandon-beaber.bsky.social @brandon-beaber.bsky.social · 19/09/2025

smoking is bad for MS, if you are taking a highly effective medication, are you in the clear? NO! This study on people taking ocrevus found smokers had more weakness, hospitalizations, and overall mortality. pubmed.ncbi.nlm.nih.gov/40967151/

pubmed.ncbi.nlm.nih.gov

Impact of smoking on clinical outcomes in ocrelizumab-treated multiple sclerosis - PubMed

In patients with MS treated with ocrelizumab, smoking was associated with significantly worse neurologic and overall outcomes. These findings highlight the importance of addressing smoking as a modifi...

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Reposted by Aaron Boster MD

Ologies with Alie Ward @ologies.bsky.social · 08/09/2025

Let's hear it for #MultipleSclerosis doc & medical hero, Dr. Aaron Boster! Send his vids to those affected by MS: www.youtube.com/c/AaronBoste... follow him at @aaronbostermd.bsky.social and listen to his Ologies ep here: www.alieward.com/ologies/neur... This ep help you? Would love to hear.

youtube.com

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Reposted by Aaron Boster MD

brandon-beaber.bsky.social @brandon-beaber.bsky.social · 28/07/2025

An explanation of "therapeutic lag: by @AaronBosterMD. How MS drugs may have long-term benefits many years later youtu.be/jBKscs__q-M?...

youtu.be

RANT: Therapeutic Lag

YouTube video by Aaron Boster MD

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Aaron Boster MD @aaronbostermd.bsky.social · 27/07/2025

Neuroplasticity = strengthening old connections, or creating NEW connections, between your brain and your muscles.

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Reposted by Aaron Boster MD

brandon-beaber.bsky.social @brandon-beaber.bsky.social · 20/07/2025

fenebrutinib (a bruton's tyrosine kinase inhibitor) for relapsing multiple sclerosis in the open label extension of the FENopta phase 2 trial. Relapse rate only 0·04 per person per year. 6% rate of elevated liver enzymes. pubmed.ncbi.nlm.nih.gov/40683275/

pubmed.ncbi.nlm.nih.gov

Safety and efficacy of fenebrutinib in relapsing multiple sclerosis (FENopta): a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial and open-label extension study - PubMed

F. Hoffmann-La Roche.

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Reposted by Aaron Boster MD

brandon-beaber.bsky.social @brandon-beaber.bsky.social · 14/07/2025

Aging in MS and treatment options with Dr. Bianca Weinstock-Guttman @MSViewsandNews. Metformin, BTKis, foralumab, CAR-T. remyelination. paramagnetic rim lesions, memory problems. youtu.be/ibcVKu5Z1zk?...

youtu.be

Aging in MS and treatment options

YouTube video by The MS Views and News Learning Channel

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Reposted by Aaron Boster MD

brandon-beaber.bsky.social @brandon-beaber.bsky.social · 14/07/2025

Changes in the 2024 revision of the McDonald diagnostic criteria for MS journals.sagepub.com/doi/10.1177/...

journals.sagepub.com

2024 revision of the McDonald diagnostic criteria for MS: Substantial and substantive changes - Jeffrey A Cohen, 2025

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Reposted by Aaron Boster MD

brandon-beaber.bsky.social @brandon-beaber.bsky.social · 12/07/2025

Upcoming videos 7/16: Mild MS 7/23: Can AI replace doctors? 7:30 Mesenchymal stem cells for MS 8/6: 18 New MS drugs! Let me know if you have video suggestions www.youtube.com/@DrBrandonBe...

youtube.com

Dr. Brandon Beaber

I am a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system, and I post new videos about MS every Wednesday Check out my...

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Reposted by Aaron Boster MD

brandon-beaber.bsky.social @brandon-beaber.bsky.social · 07/07/2025

Neurologist Reveals 10 Sneaky MS Symptoms You Shouldn't Ignore! by @aaronbostermd.bsky.social . Depression/mood changes, cog fog, motor fatigue, proprioception loss, "shy bladder," constipation, double vision, bizarre sensations, sexual changes, social cognition youtu.be/AP04cChsiGw?...

youtu.be

Neurologist Reveals 10 Sneaky MS Symptoms You Shouldn't Ignore!

YouTube video by Aaron Boster MD

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Reposted by Aaron Boster MD

brandon-beaber.bsky.social @brandon-beaber.bsky.social · 05/07/2025

Dr. Regina Berkovich (one of my former fellowship mentors when I was at USC) on multiple sclerosis progression independent of relapses, drug development, and lifestyle changes. Interview with @MSNewsToday multiplesclerosisnewstoday.com/news-posts/2...

multiplesclerosisnewstoday.com

MS quiet progression: Expert discusses new research, treatment

A multiple sclerosis specialist shares insights on quiet progression, and discusses research and treatments for MS activity without relapses.

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Reposted by Aaron Boster MD

brandon-beaber.bsky.social @brandon-beaber.bsky.social · 18/06/2025

Multiple Sclerosis Treated Early and Aggressively. Results of an observational study: Do people still develop progressive MS? youtu.be/j4xIDuWWXJY?...

youtu.be

Multiple Sclerosis Treated Early and Aggressively

YouTube video by Dr. Brandon Beaber

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Reposted by Aaron Boster MD

brandon-beaber.bsky.social @brandon-beaber.bsky.social · 02/06/2025

Reversing MS Symptoms? The Power of Remyelination By @aaronbostermd.bsky.social Clemastine. Anti-LINGO-1. PIPE-307. Oligodendrocyte precursor cells. youtu.be/I4FNmAzh5oA?...

youtu.be

Reversing MS Symptoms? The Power of Remyelination

YouTube video by Aaron Boster MD

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Reposted by Aaron Boster MD

brandon-beaber.bsky.social @brandon-beaber.bsky.social · 30/05/2025

Does ocrevus work in pediatric MS? This case series (n= 24) showed low rates of relapses (0.08 per person per year). Disability as measured by EDSS stabilized in 75% and improved in 16.7% pubmed.ncbi.nlm.nih.gov/40435665/

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Reposted by Aaron Boster MD

brandon-beaber.bsky.social @brandon-beaber.bsky.social · 26/05/2025

rituximab vs. mavenclad for multiple sclerosis. This retrospective observational study found MRI activity was much lower in those receiving rituximab (17% vs 57% over a median follow up of 4.5 years), but side effects more common with rituximab pubmed.ncbi.nlm.nih.gov/40415655/

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Reposted by Aaron Boster MD

George Takei @georgetakei.bsky.social · 25/05/2025

This Memorial Day weekend, the best way to honor the soldiers who gave the ultimate sacrifice is to honor and protect the freedoms and the democracy they died for.

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Reposted by Aaron Boster MD

The New Yorker @newyorker.com · 25/05/2025

Academic freedom in the United States has found itself periodically under siege, but the current attacks from the federal government raise a new level of alarm. nyer.cm/u405qvQ

“I’ve studied McCarthyism’s impact on higher education for 50 years. What’s happening now is worse.” -Ellen Schrecker, historian

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Reposted by Aaron Boster MD

Hank Green @hankgreen.bsky.social · 20/05/2025

Twelve years (and 2.1 billion views) ago, when my brother and I decided that we could make videos that could maybe help people in their high school and college educations and then give them away for free, no one was there to tell us we were crazy, and I am very glad for that...🧵

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Reposted by Aaron Boster MD

brandon-beaber.bsky.social @brandon-beaber.bsky.social · 07/05/2025

CAR-T Therapy for Multiple Sclerosis Explained by Neurologist youtu.be/xxwE-KzP7H0?...

youtu.be

CAR-T Therapy for Multiple Sclerosis Explained by Neurologist

YouTube video by Dr. Brandon Beaber

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Reposted by Aaron Boster MD

brandon-beaber.bsky.social @brandon-beaber.bsky.social · 29/04/2025

Can you avoid getting epsteinn barr virus? It's probably nearly impossible. This study from France shows EBV seroprevalence hardly changed during the peak of the covid-19 pandemic despite masking and social distancing. www.mdpi.com/2076-2607/13...

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Reposted by Aaron Boster MD

brandon-beaber.bsky.social @brandon-beaber.bsky.social · 16/04/2025

I asked neurologists at the American Academy of Neurology Annual Meeting, "What MS research, innovation, or impending technology are you most excited about." Here's what they said. www.youtube.com/watch?v=JFZ0...

youtube.com

Neurologists: What MS Research Excites You Most?

YouTube video by Dr. Brandon Beaber

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Reposted by Aaron Boster MD

brandon-beaber.bsky.social @brandon-beaber.bsky.social · 15/04/2025

Elevated Kappa-free light chains (κ-FLC) in the CSF are 88% sensitive and 89% specific for MS (typical cutoff CSF value of 0.96 mg/L), similar to CSF oligoclonal bands. uhttps://pmc.ncbi.nlm.nih.gov/articles/PMC9925908/

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Reposted by Aaron Boster MD

brandon-beaber.bsky.social @brandon-beaber.bsky.social · 13/04/2025

The proposed new diagnostic criteria for multiple sclerosis for individuals WITHOUT signs/symptoms suggestive of demyelinating disease ectrims.eu/mcdonald-dia...

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