iiinova — where your digital self keeps evolving

Boyi Guo (郭博逸) @boyiguo.bsky.social · 20/02/2026

🚨Preprint alert! I'm excited to share a new preprint co-led with the talented @shkwon-bcmbneuro.bsky.social during my postdoc at @jhubiostat.bsky.social . In this project, we investigated the 𝐦𝐨𝐥𝐞𝐜𝐮𝐥𝐚𝐫 𝐩𝐚𝐭𝐡𝐨𝐥𝐨𝐠𝐲 𝐨𝐟 𝐬𝐜𝐡𝐢𝐳𝐨𝐩𝐡𝐫𝐞𝐧𝐢𝐚 𝐢𝐧 𝐝𝐥𝐏𝐅𝐂 𝐮𝐬𝐢𝐧𝐠 𝐭𝐡𝐞 𝐜𝐮𝐭𝐭𝐢𝐧𝐠-𝐞𝐝𝐠𝐞 𝐬𝐩𝐚𝐭𝐢𝐚𝐥 𝐦𝐮𝐥𝐭𝐢-𝐨𝐦𝐢𝐜𝐬 𝐚𝐩𝐩𝐫𝐨𝐚𝐜𝐡.

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Boyi Guo (郭博逸) @boyiguo.bsky.social · 22/07/2025

"Absurd ad hoc analysis pipelines are justified solely by their results, not by their logic. And once they are published, open code just makes things worse, because other researchers use the code to publish more rubbish."

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Rita Strack @ritastrack.bsky.social · 09/07/2025

Yes, we should give you guidance up front. Also, as I frequently say, if you ever have a question about what your editor wants to see in a revision, ask us to review/approve a revision plan. I never want my authors losing sleep over my expectations. Truly.

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Rita Strack @ritastrack.bsky.social · 09/07/2025

Sometimes authors summarize their responses to 3-6 major points raised by the reviewers in their resub cover letters or at the top of their rebuttal letters. This is so super helpful to editors, because it brings us right up to speed after not having read the paper/reviews for months. THANKS!!

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Boyi Guo (郭博逸) @boyiguo.bsky.social · 24/06/2025

Inspiring read to understand where the genomics study of complex psychiatric disorder stands now. Very excited how spatial transcriptomics contributes enlightening mediating effect of genetic risk variants. Some cool work is brewing! www.nature.com/articles/s41...

nature.com

Genomics of schizophrenia, bipolar disorder and major depressive disorder

Nature Reviews Genetics - Genomic advances have enhanced our understanding of schizophrenia, bipolar disorder and major depressive disorder, revealing genetic architectures and risk mechanisms...

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Kinnary Shah @kinnaryshah.bsky.social · 17/06/2025

my work with @stephaniehicks.bsky.social and @boyiguo.bsky.social has been published in Biostatistics! tldr: the mean-variance bias exists in SRT data & impacts SVG detection. we propose #spoon, available on @bioconductor.bsky.social, to address this! pmc.ncbi.nlm.nih.gov/articles/PMC... 🤩

pmc.ncbi.nlm.nih.gov

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🇲🇽 Leonardo Collado-Torres @lcolladotor.bsky.social · 10/06/2025

#SpotSweeper is now published! Check our journal club session summary of the pre-print version by @lahuuki.bsky.social The new features @boyiguo.bsky.social + @mictott.bsky.social added in this revised manuscript enhance the use cases for #SpotSweeper: 👀 #VisiumHD data! youtu.be/f72XcXmtkfw?...

youtu.be

[2024-09-04] Journal club on SpotSweeper

YouTube video by Leonardo Collado Torres

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Boyi Guo (郭博逸) @boyiguo.bsky.social · 10/06/2025

Great collaboration motivates methodological and biological innovation! Grateful for the opportunity to work together with @martinowk.bsky.social and @lieberinstitute.bsky.social, investigating the molecular pathology of neuropsychiatric disorder, coming soon! 😉

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Keri Martinowich @martinowk.bsky.social · 06/06/2025

Important methods development for spatial transcriptomics (ST) data from @mictott.bsky.social @boyiguo.bsky.social @stephaniehicks.bsky.social - congrats! Applying this method to our QC workflow has substantially improved many new ST datasets generated across diverse regions/tissues in the human 🧠

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Boyi Guo (郭博逸) @boyiguo.bsky.social · 09/06/2025

Excited to announce that I'll start as a tenure-track assistant professor @uofuphs.bsky.social this fall. #BiostatsElevated The #GUOmics lab will focus on developing biologically informed machine learning methods to decode spatial and population-scale omics data. Look forward to exciting colabs!

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Boyi Guo (郭博逸) @boyiguo.bsky.social · 06/06/2025

🤔Could quality control create more harm than good? We explore this question in the context of #SRT. SpotSweeper is developed to combat implicit selection bias. Led by fellow rising star @mictott.bsky.social and collab with amazing mentor @stephaniehicks.bsky.social 👉: bsky.app/profile/mict...

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Rita Strack @ritastrack.bsky.social · 10/04/2025

Your yearly reminder to acknowledge the core facilities you use and their staff scientists in your papers. These scientists are a crucial part of the scientific ecosystem and to continue to exist they need tangible credit for their work. Plus their associated expertise adds credibility to your work.

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Boyi Guo (郭博逸) @boyiguo.bsky.social · 26/03/2025

"An open letter to graduate students and other procrastinators: it’s time to write" www.nature.com/articles/s41... Enjoyed reading the article, and reflect on my own writing workflow. Plan to include in my lab handbook as resources for trainees. #PDL#writing#comp-lab

nature.com

An open letter to graduate students and other procrastinators: it’s time to write - Nature Biotechnology

Nature Biotechnology - An open letter to graduate students and other procrastinators: it’s time to write

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Stephanie Hicks @stephaniehicks.bsky.social · 05/12/2024

Excited to share a new algorithm that we have been working on over the last year. 💡 idea is to extend mutual nearest neighbors for #spatial data. We call it spatial mutual nearest neighbors (spatialMNN) 😄 Thank you @haowen-zhou.bsky.social @pratibha-panwar.bsky.social who led this work! 👏 🧬🖥️🧪

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Kinnary Shah @kinnaryshah.bsky.social · 16/11/2024

thank you @stephaniehicks.bsky.social and @boyiguo.bsky.social for your amazing mentorship on this project! so excited that this is finally out

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