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Raphaël Chaleil

@blastwizard.bsky.social
51 followers 111 following 19 posts

Computational Protein Engineer at @basecamp-research.bsky.social

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Reposted by Raphaël Chaleil
Sergey Ovchinnikov @sokrypton.org · 15/08/2026
Adding support for cyclic L/D peptide mixes.
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Reposted by Raphaël Chaleil
Emma Slack @mucosalimmunology.bsky.social · 01/07/2026
We are recruiting a lab manager for my group in Oxford. This is a lovely team doing great things, and you could be an important part of it! See here: www.path.ox.ac.uk/vacancy/lab-... Please spread the word!
path.ox.ac.uk
Lab Manager - Molecular Immunology - Dunn School
Laboratory Manager/Senior Scientist position in the Molecular Mucosal Immunology group at Oxford
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bmcarthur17 @bmcarthur17.bsky.social · 16/08/2025
This Brit nails it. #Immigration
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Raphaël Chaleil @blastwizard.bsky.social · 31/05/2026
One of the numerous benefits of brexit, protecting British farmers, by importing chicken from Thailand and not being able to export the finished product to the EU.
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Kat Arney @katarney.bsky.social · 22/04/2026
Epistemic collapse is nigh... I wrote about it here: How to survive the AI Slopocalypse www.linkedin.com/pulse/how-su...
linkedin.com
How to survive the AI Slopocalypse
It took 50 years for Gutenberg's invention of the printing press to spawn 9 million books. It's been three short years since ChatGPT was launched, and it feels like I've seen that many pieces of AI sl...
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Reposted by Raphaël Chaleil
Kat Arney @katarney.bsky.social · 14/04/2026
The two golden rules of using AI in content creation: know your shit, and know what's shit. www.linkedin.com/pulse/two-go... Inspired by some particularly egregious recent incidents I experienced, and @naomialderman.bsky.social writing about the importance of discernment when using these tools.
linkedin.com
The two golden rules for using AI to generate content: Know your sh1t. And know what's sh1t.
It's become quite trendy to rant about the growing amount of poor quality AI-generated content circulating online - I myself have written about the coming AI Slopocalypse and how to survive it. But th...
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Dale Ryder @kryton3298.bsky.social · 19/03/2026
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Basecamp Research @basecamp-research.bsky.social · 18/03/2026
We’re launching the Trillion Gene Atlas with Anthropic, NVIDIA, PacBio, and UltimaGenomics. 🌍 The Goal: To expand known genomes 100×, sequencing 100M+ species to build foundation models grounded in evolution itself. 🔗 Read more: www.prnewswire.com/news-release...
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Basecamp Research @basecamp-research.bsky.social · 15/01/2026
Introducing EDEN — a 28B-parameter biological foundation model trained on 9.7T nucleotide tokens, including >10B novel genes from >1M species. This evolutionary scale is what makes generalisable biological design possible. Paper: www.biorxiv.org/content/10.6...
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Kevin K. Yang 楊凱筌 @kevinkaichuang.bsky.social · 13/01/2026
EDEN: a family of genomic language models trained on up to 9.7 trillion nucleotides from @basecamp-research.bsky.social's BaseData can design large serine recombinases, bridge recombinases, and antimicrobial peptides. www.biorxiv.org/content/10.6... Happy to have played a small part in this!
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Basecamp Research @basecamp-research.bsky.social · 06/11/2025
How can AI and nature’s hidden code lead to programmable gene therapies? Basecamp Research Co-founder & CEO GlenGowers.bsky.social explores this question at @financialtimes.com Times Live Global Pharma and Biotech Summit (Nov 11–12) with industry leaders. 👉 For full details, visit bit.ly/4pPcJpd
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Joe Greener @jgreener64.bsky.social · 04/07/2025
A real shame that the future of CASP is in doubt. There is still a lot of progress to be assessed (complexes, nucleic acids, ligands, ensembles). CASP has also been a pioneer in how to run blind assessments. www.science.org/content/arti...
science.org
Exclusive: Famed protein structure competition nears end as NIH grant money runs out
Agency silent on funding renewal for contest that inspired creation of AIs that predicted how proteins would fold
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Raphaël Chaleil @blastwizard.bsky.social · 13/06/2025
www.change.org/p/sauvons-le...
change.org
Signez la pétition
Sauvons le Palais de la découverte
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Reposted by Raphaël Chaleil
Albert Vilella, PhD. @albertvilella.bsky.social · 31/05/2025
Seen on LinkedIn, a bit on the nose, comparing Machine learning to AI and now GenAI and AgenticAI
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Raphaël Chaleil @blastwizard.bsky.social · 25/04/2025
First roses of the year.
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Emma Slack @mucosalimmunology.bsky.social · 22/02/2025
We are recruiting @ox.ac.uk @dunnschool.bsky.social for a joint project between Kevin Foster's group and mine! Cluster hire of two postdocs interested in: 1) Mucosal immunology and oral vaccine development my.corehr.com/pls/uoxrecru... 2) Microbiology my.corehr.com/pls/uoxrecru... Please share!
my.corehr.com
'
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Bad Faerie @bad-faerie.bsky.social · 05/03/2025
youtu.be/q32Zz2dBkos If you want to know how Europeans feel listen to Claude Malhuret, He is the leader of the independents in France. This is how they see the US now. That's the full translation. Worth a listen
youtu.be
Video IGGY HOBO translation v1
YouTube video by yep it's,me
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Eric Topol @erictopol.bsky.social · 01/03/2025
Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter www.nytimes.com/2025/03/01/u...
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Jon Cooper @joncooper-us.bsky.social · 28/02/2025
Pass it on. #StandWithUkraine
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Joe Greener @jgreener64.bsky.social · 08/01/2025
Favourite paper of 2017 "Protein structure determination using metagenome sequence data" by Ovchinnikov et al. (1/4) www.science.org/doi/10.1126/...
science.org
Protein structure determination using metagenome sequence data
Combining metagenome data with protein structure prediction generates models for 614 families with unknown structures.
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Reposted by Raphaël Chaleil
Tim Stearns @stearnslab.bsky.social · 30/12/2024
Good article on the OpenFold work of @moalquraishi.bsky.social, who poses the interesting question: If we can predict how proteins fold without understanding how they do it, “are we even legitimately doing science anymore, or is it something different?“ magazine.hms.harvard.edu/articles/did...
magazine.hms.harvard.edu
Did AI Solve the Protein-Folding Problem?
Now that AlphaFold has tackled biology’s greatest challenge, scientists can turn to even bigger questions
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Basecamp Research @basecamp-research.bsky.social · 06/12/2024
Basecamp Research cofounder and CEO Glen Gowers, Ph.D., spoke about AI and drug discovery at the 2024 Forbes Healthcare Summit in New York City. #ForbesHealth trib.al/aVWj2tF Thanks to @forbes.com and @thealexknapp.bsky.social for an amazing summit a thought-provoking event.
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Arne Elofsson @handle.invalid · 03/12/2024
Conclusions from RNA section at #CASP16, without a template all fail. All small targets had a template.
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Raphaël Chaleil @blastwizard.bsky.social · 19/11/2024
First snow, that's a bit unusual at this time of the year.
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Raphaël Chaleil @blastwizard.bsky.social · 17/11/2024
November and the rose in front of the house is still flowering.
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Alex Knapp @thealexknapp.bsky.social · 12/03/2024
New from me: Basecamp Research, which is collecting reference-quality genomes in collaboration with research groups around the world, says its protein folding model significantly out-performs Deepmind's Alphafold2. www.forbes.com/sites/alexkn...
forbes.com
This Startup Says It Can Beat Deepmind’s Gamechanging Protein AI
Basecamp Research says its software platform can better predict the way proteins behave — not with better algorithms, but with higher-quality data.
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TechCrunch @techcrunch.com · 09/10/2024
Basecamp Research taps $60M to build a ‘GPT for biology’
tcrn.ch
Basecamp Research taps $60M to build a ‘GPT for biology’
While companies like OpenAI and Anthropic continue to popularize the idea of people using ordinary language to ask artificial intelligence agents to answer their questions, write their proposals, and draw pictures, a London startup called Basecamp…
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